AMPK、FOXO3A 和 POMC 的基因变异会增加极度肥胖的风险。

IF 3.8 Q2 ENDOCRINOLOGY & METABOLISM Journal of Obesity Pub Date : 2024-10-24 eCollection Date: 2024-01-01 DOI:10.1155/2024/3813621
Cinthia Vila Nova Santana, Luiz Alexandre Viana Magno, Adauto Versiani Ramos, Maria Angélica Rios, Valéria Cristina Sandrim, Luiz Armando De Marco, Débora Marques de Miranda, Marco Aurélio Romano-Silva
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引用次数: 0

摘要

目的基因变异对新陈代谢、体重增加和进食行为有重大影响,易导致肥胖。本研究探讨了与肥胖有关的关键基因--FOXO3A(叉头盒 O3)、AMPK(蛋白激酶 AMP-活化)和 POMC(原髓皮质素)的变异如何与极度肥胖(EOB)相关。研究方法我们对 251 名 EOB 患者和 212 名体重指数(BMI)低于 25 kg/m2 的健康对照者进行了病例对照研究。我们使用基于 TaqMan 的检测方法对 10 个单核苷酸变异体 (SNV) 进行了基因分型。结果显示FOXO3A 中的四个 SNVs-rs1536057、AMPK 中的 rs103685、rs934778 和 POMC 中的 rs6545975 与 EOB 风险增加有关。其中,rs934778(POMC)的关联性最强,其最大比值比 (OR) 为 5.26(95% CI:2.86-9.09)。虽然这些基因变异与 EOB 密切相关,但它们并不影响血清葡萄糖、甘油三酯、高密度脂蛋白、低密度脂蛋白、体重指数或腰围。结论:这些研究结果表明,传统代谢途径之外的因素(可能与进食行为或激素调节有关)也可能将这些基因变异与肥胖联系在一起。要验证这些发现并探索其指导临床干预和公共卫生策略的潜力,必须在更大样本中开展进一步研究。
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Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity.

Objective: Genetic variability significantly impacts metabolism, weight gain, and feeding behaviors, predisposing individuals to obesity. This study explored how variations in key genes related to obesity-FOXO3A (forkhead box O3), AMPK (protein kinase AMP-activated), and POMC (proopiomelanocortin)-are associated with extreme obesity (EOB). Methods: We conducted a case-control study with 251 EOB patients and 212 healthy controls with a body mass index (BMI) of less than 25 kg/m2. We genotyped 10 single nucleotide variants (SNVs) using TaqMan-based assays. Results: Four SNVs-rs1536057 in FOXO3A, rs103685 in AMPK, rs934778, and rs6545975 in POMC-were associated with an increased risk of EOB. The strongest association was observed with rs934778 (POMC), which had a maximum odds ratio (OR) of 5.26 (95% CI: 2.86-9.09). While these genetic variations are closely linked to EOB, they do not affect serum glucose, triglycerides, HDL, LDL, BMI, or waist circumference. Conclusions: These findings indicate that factors beyond traditional metabolic pathways, potentially related to feeding behavior or hormonal regulation, may also link these genetic variations to obesity. Further research in a larger sample is essential to validate these findings and explore their potential to guide clinical interventions and public health strategies.

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来源期刊
Journal of Obesity
Journal of Obesity ENDOCRINOLOGY & METABOLISM-
CiteScore
7.50
自引率
3.00%
发文量
19
审稿时长
21 weeks
期刊介绍: Journal of Obesity is a peer-reviewed, Open Access journal that provides a multidisciplinary forum for basic and clinical research as well as applied studies in the areas of adipocyte biology & physiology, lipid metabolism, metabolic syndrome, diabetes, paediatric obesity, genetics, behavioural epidemiology, nutrition & eating disorders, exercise & human physiology, weight control and health risks associated with obesity.
期刊最新文献
Genetic Variations in AMPK, FOXO3A, and POMC Increase the Risk of Extreme Obesity. Microarray Analysis of Visceral Adipose Tissue in Obese Women Reveals Common Crossroads Among Inflammation, Metabolism, Addictive Behaviors, and Cancer: AKT3 and MAPK1 Cross Point in Obesity. Delayed Gut Colonization Changes Future Insulin Resistance and Hepatic Gene Expression but Not Adiposity in Obese Mice. Relationship of Mitochondrial DNA Oxidation and Content with Metabolic Syndrome and Cardiovascular Risk in Obesity Phenotypes. Beneficial Effects of Capybara Oil Supplementation on Steatosis and Liver Apoptosis in Obese Mice.
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