在客户饲养的健康犬中口服两种剂量埃索美拉唑的药效学:前瞻性交叉研究。

IF 2.6 2区 农林科学 Journal of Veterinary Internal Medicine Pub Date : 2024-10-31 DOI:10.1111/jvim.17233
Abby Ostronic, Christine Gremillion, Song Zhang, Joerg M Steiner, M Katherine Tolbert, Emily N Gould
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引用次数: 0

摘要

背景:埃索美拉唑在犬中的使用越来越多,但由于每 12 小时给药一次会引起胃肠道不良反应,因此有必要对其进行药效学评估:埃索美拉唑在犬中的使用越来越多,但由于q12h给药会引起胃肠道不良反应,因此有必要对减少给药剂量和频率进行药效学评估:比较两种剂量(q24h)的埃索美拉唑提高犬胃内pH值的疗效:方法:前瞻性、随机、双盲试验:前瞻性、随机、双盲、交叉研究。每个治疗组口服埃索美拉唑(0.5或1毫克/千克,q24小时)最多5天,使用连续pH值监测系统比较24小时胃内pH值≥3(MPT3)和≥4(MPT4)的平均时间百分比与治疗前pH值。每天给药一次但未能达到pH值目标(MPT3 ≥75%,MPT4 ≥66%)的狗接受埃索美拉唑1 mg/kg PO q12h治疗,以确定更高的剂量是否能改善抑酸效果:任何时间点的 MPT3 或 MPT4 均无明显差异(P > .05)。两种剂量在第 1 天(MPT3:76.8% [44-100],69.2% [28.2-100];MPT4:65.6% [16.7-99.3],54.9% [14.9-93.3];P = .0009)和第 2 天(MPT3:77.2% [27.4-100],75.4% [49.4-89.5];MPT4:66.3% [15.5-100],59.7% [33.8-81.2];P = .0005)PPI 治疗与治疗前相比(MPT3:58.3% [0.02-93.9],52.6% [6.1-94.7];MPT4:25.2% [0-86.8],32.4% [1.8-89.3])。六只狗(66%,[0.36, 0.97])通过 q24h 给药达到了人类设定的 pH 值目标:结论和临床意义:尽管受试者之间的差异很大,但两种q24小时给药的埃索美拉唑剂量都能有效提高胃内pH值,但33%的狗需要q12小时给药才能达到pH值目标。
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Pharmacodynamics of 2 dosages of orally administered esomeprazole in client-owned, healthy dogs: A prospective, crossover study.

Background: Esomeprazole use is increasing in dogs, but the gastrointestinal adverse events associated with q12h dosing necessitate pharmacodynamic evaluation of a reduced dose and frequency of administration.

Objectives: To compare the efficacy of 2 doses of (q24h) esomeprazole in raising intragastric pH in dogs.

Animals: Nine healthy, client-owned dogs, >20 kg.

Methods: Prospective, randomized, double blinded, crossover study. Esomeprazole (0.5 or 1 mg/kg q24h) was orally administered for up to 5 days per treatment arm, and the mean percentage time intragastric pH was ≥3 (MPT3) and ≥4 (MPT4) for 24 hours periods were compared to pretreatment pH using a continuous pH monitoring system. Dogs failing to reach pH goals (MPT3 ≥75%, MPT4 ≥66%) with once daily dosing received esomeprazole 1 mg/kg PO q12h to determine if a higher dose would improve acid suppression.

Results: No significant difference in the MPT3 or MPT4 was identified between treatments for any time point (P > .05). Both doses increased the MPT pH ≥3 and 4 median [range] (0.5 mg/kg, 1 mg/kg) on days 1 (MPT3: 76.8% [44-100], 69.2% [28.2-100]; MPT4: 65.6% [16.7-99.3], 54.9% [14.9-93.3]; P = .0009) and 2 (MPT3:77.2% [27.4-100], 75.4% [49.4-89.5]; MPT4: 66.3% [15.5-100], 59.7% [33.8-81.2]; P = .0005) of PPI treatment compared to pretreatment (MPT3: 58.3% [0.02-93.9], 52.6% [6.1-94.7]; MPT4: 25.2% [0-86.8], 32.4% [1.8-89.3]). Six dogs (66%, [0.36, 0.97]) reached pH goals established in humans with q24h dosing.

Conclusions and clinical importance: Both q24h PO esomeprazole doses were effective in raising intragastric pH, despite high intersubject variability, but 33% of dogs required q12h dosing to reach pH goals.

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来源期刊
Journal of Veterinary Internal Medicine
Journal of Veterinary Internal Medicine Veterinary-General Veterinary
自引率
11.50%
发文量
243
期刊介绍: The mission of the Journal of Veterinary Internal Medicine is to advance veterinary medical knowledge and improve the lives of animals by publication of authoritative scientific articles of animal diseases.
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