中风与相对脂肪量之间的关系：基于 NHANES 的横断面研究。

IF 3.9 2区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Lipids in Health and Disease Pub Date : 2024-10-31 DOI:10.1186/s12944-024-02351-2

Yafang Zheng, Chunyuan Huang, Jing Jin, Ying Zhao, Haoyang Cui, Chuanxiang Wei

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引用次数: 0

摘要

背景：本研究旨在探讨中风的发生与相对脂肪量（RFM）之间的相关性：本研究旨在探讨中风的发生与相对脂肪量（RFM）之间的相关性：这项横断面研究采用了 2005 年至 2018 年的美国国家健康与营养调查（NHANES）数据集，以评估相对脂肪量与中风之间的独立关系。此外，还采用了多项式逻辑回归、亚组分析、平滑曲线拟合和交互检验等方法：本研究共纳入 35842 名参与者，其中 1267 人（3.53%）被诊断为中风。完全调整模型显示，RFM 与中风呈正相关（几率比 [OR] = 1.02；95% 置信区间 [CI] = 1.01-1.03）。与四分位数 1 相比，四分位数 4 患中风的几率明显增加了 44%（OR = 1.44，95% 置信区间：1.09-1.90）。此外，亚组分析还显示，年龄和体重指数对 RFM 与中风之间的关系有明显影响（P 为交互作用结论：RFM 升高与中风的发生有关：RFM升高与中风几率增加有关，这表明RFM在中风的预防和管理中可能具有潜在价值。

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Association between stroke and relative fat mass: a cross-sectional study based on NHANES.

Background: This study was aimed at investigating the correlation between the occurrence of stroke and relative fat mass (RFM), a novel metric for determining total body fat.

Methods: This cross-sectional study employed the National Health and Nutrition Examination Survey (NHANES) dataset, which encompassed the years 2005 to 2018 to assess the independent relationship between RFM and stroke. Moreover, multinomial logistic regression, subgroup analysis, smooth curve fitting, and interaction testing were also used.

Results: This study included 35,842 participants and 1,267 (3.53%) of them were diagnosed with stroke. Fully adjusted Models showed that RFM was positively associated with stroke (odds ratio [OR] = 1.02; 95% confidence interval [CI] = 1.01-1.03). The odds of having a stroke in quartile 4 were significantly elevated by 44%, compared to quartile 1 (OR = 1.44,95%CI:1.09-1.90). In addition, a subgroup analysis also demonstrated that age and BMI significantly impacted the association between RFM and stroke (P for interaction<0.01).

Conclusions: Elevated RFM is associated with increased odds of stroke, suggesting that RFM may have potential value in the prevention and management of stroke.

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来源期刊

Lipids in Health and Disease 生物-生化与分子生物学

CiteScore

7.70

自引率

2.20%

发文量

122

审稿时长

3-8 weeks

期刊介绍： Lipids in Health and Disease is an open access, peer-reviewed, journal that publishes articles on all aspects of lipids: their biochemistry, pharmacology, toxicology, role in health and disease, and the synthesis of new lipid compounds. Lipids in Health and Disease is aimed at all scientists, health professionals and physicians interested in the area of lipids. Lipids are defined here in their broadest sense, to include: cholesterol, essential fatty acids, saturated fatty acids, phospholipids, inositol lipids, second messenger lipids, enzymes and synthetic machinery that is involved in the metabolism of various lipids in the cells and tissues, and also various aspects of lipid transport, etc. In addition, the journal also publishes research that investigates and defines the role of lipids in various physiological processes, pathology and disease. In particular, the journal aims to bridge the gap between the bench and the clinic by publishing articles that are particularly relevant to human diseases and the role of lipids in the management of various diseases.