{"title":"细菌分裂征服抗生素","authors":"Ewan Harrison","doi":"10.1126/science.adt0042","DOIUrl":null,"url":null,"abstract":"<div >Antibiotics are a cornerstone of modern medicine, and consequently, antibiotic resistance is a serious public health threat to treating bacterial infections. Shortly after penicillin came into clinical use to treat <i>Staphylococcus aureus</i>—a pathogen that can cause mild to fatal infections—strains resistant to the drug emerged. In 1959, the antibiotic methicillin was introduced to treat penicillin-resistant strains of <i>S. aureus</i>. Methicillin is a member of the β-lactam family of antibiotics that are broadly effective against many types of bacteria. However, by 1960, infections with methicillin-resistant <i>S. aureus</i> (MRSA) had been reported (<i>1</i>). Given the importance of β-lactams for treating <i>S. aureus</i> infections, researchers have sought to understand the mechanism and evolutionary origins of this resistance. On page 573 of this issue, Adedeji-Olulana <i>et al</i>. (<i>2</i>) report that high-level resistance to methicillin requires <i>S. aureus</i> to use a distinct form of cell division to ensure its survival.</div>","PeriodicalId":21678,"journal":{"name":"Science","volume":"386 6721","pages":""},"PeriodicalIF":44.7000,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Bacteria divide to conquer antibiotics\",\"authors\":\"Ewan Harrison\",\"doi\":\"10.1126/science.adt0042\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div >Antibiotics are a cornerstone of modern medicine, and consequently, antibiotic resistance is a serious public health threat to treating bacterial infections. Shortly after penicillin came into clinical use to treat <i>Staphylococcus aureus</i>—a pathogen that can cause mild to fatal infections—strains resistant to the drug emerged. In 1959, the antibiotic methicillin was introduced to treat penicillin-resistant strains of <i>S. aureus</i>. Methicillin is a member of the β-lactam family of antibiotics that are broadly effective against many types of bacteria. However, by 1960, infections with methicillin-resistant <i>S. aureus</i> (MRSA) had been reported (<i>1</i>). Given the importance of β-lactams for treating <i>S. aureus</i> infections, researchers have sought to understand the mechanism and evolutionary origins of this resistance. On page 573 of this issue, Adedeji-Olulana <i>et al</i>. (<i>2</i>) report that high-level resistance to methicillin requires <i>S. aureus</i> to use a distinct form of cell division to ensure its survival.</div>\",\"PeriodicalId\":21678,\"journal\":{\"name\":\"Science\",\"volume\":\"386 6721\",\"pages\":\"\"},\"PeriodicalIF\":44.7000,\"publicationDate\":\"2024-10-31\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://www.science.org/doi/10.1126/science.adt0042\",\"RegionNum\":1,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science","FirstCategoryId":"103","ListUrlMain":"https://www.science.org/doi/10.1126/science.adt0042","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
Antibiotics are a cornerstone of modern medicine, and consequently, antibiotic resistance is a serious public health threat to treating bacterial infections. Shortly after penicillin came into clinical use to treat Staphylococcus aureus—a pathogen that can cause mild to fatal infections—strains resistant to the drug emerged. In 1959, the antibiotic methicillin was introduced to treat penicillin-resistant strains of S. aureus. Methicillin is a member of the β-lactam family of antibiotics that are broadly effective against many types of bacteria. However, by 1960, infections with methicillin-resistant S. aureus (MRSA) had been reported (1). Given the importance of β-lactams for treating S. aureus infections, researchers have sought to understand the mechanism and evolutionary origins of this resistance. On page 573 of this issue, Adedeji-Olulana et al. (2) report that high-level resistance to methicillin requires S. aureus to use a distinct form of cell division to ensure its survival.
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