缺氧癌细胞新陈代谢的转录调控与人工智能。

IF 14.3 1区 医学 Q1 ONCOLOGY Trends in cancer Pub Date : 2024-10-30 DOI:10.1016/j.trecan.2024.10.003
Luana Schito, Sergio Rey-Keim
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引用次数: 0

摘要

缺氧肿瘤微环境中的基因表达调控是由氧气反应性转录因子(O2R-TFs)介导的,根据氧气的可用性微调癌细胞对氧气的代谢需求。在此,我们将讨论关键的 O2R-TFs 和基于人工智能 (AI) 的新兴应用,这些应用适用于研究 O2R-TF 关系,从而确定癌细胞对缺氧的代谢适应性。
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Transcriptional regulation of hypoxic cancer cell metabolism and artificial intelligence.

Gene expression regulation in hypoxic tumor microenvironments is mediated by O2 responsive transcription factors (O2R-TFs), fine-tuning cancer cell metabolic demand for O2 according to its availability. Here, we discuss key O2R-TFs and emerging artificial intelligence (AI)-based applications suitable for the interrogation of O2R-TF relationships specifying cancer cell metabolic adaptations to hypoxia.

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来源期刊
Trends in cancer
Trends in cancer Medicine-Oncology
CiteScore
28.50
自引率
0.50%
发文量
138
期刊介绍: Trends in Cancer, a part of the Trends review journals, delivers concise and engaging expert commentary on key research topics and cutting-edge advances in cancer discovery and medicine. Trends in Cancer serves as a unique platform for multidisciplinary information, fostering discussion and education for scientists, clinicians, policy makers, and patients & advocates.Covering various aspects, it presents opportunities, challenges, and impacts of basic, translational, and clinical findings, industry R&D, technology, innovation, ethics, and cancer policy and funding in an authoritative yet reader-friendly format.
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