炎症指标在百岁老人睡眠状况与血压关系中的中介作用:来自中国海南百岁老人队列研究的证据。

IF 1.8 4区 医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS Journal of Geriatric Cardiology Pub Date : 2024-09-28 DOI:10.26599/1671-5411.2024.09.009
Qiao Li, Sheng-Shu Wang, Guang-Dong Liu, Jian-Hua Wang, Ya-Li Zhao, Miao Liu, Yao He, Shan-Shan Yang
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引用次数: 0

摘要

研究目的对海南百岁老人的睡眠状况与血压状况之间的联系进行全面分析。方法:中国海南百岁老人队列研究(CHCCS)收集了海南百岁老人的睡眠状况、血压状况和炎症指标的基线数据:方法:中国海南百岁老人队列研究(CHCCS)收集了睡眠状态基线数据、炎症指标和血压数据。研究采用中介模型来探讨炎症指标如何中介睡眠状态与血压状态之间的关系:这项研究共纳入了 967 名百岁老人。百岁老人的高血压患病率为 71.4%。分析表明,与睡眠质量正常的百岁老人相比,睡眠质量差的百岁老人患高血压的风险高出 43%(OR = 1.43,95% CI:1.03-1.97)。此外,夜间睡眠时间≤6小时或>9小时的百岁老人患高脉压(PP)的比例较高,OR值分别为1.76(95% CI:1.18-2.63)和2.07(95% CI:1.34-3.19)。中介分析表明,补体 C3 在睡眠质量与高血压的关系中起中介作用,效应比为 2.4%。同样,淋巴细胞计数、中性粒细胞与淋巴细胞比值(NLR)和全身免疫炎症指数(SII)也被确定为夜间睡眠时间与高 PP 之间关系的中介因素,其效应比分别为 91.22%、36.93% 和 0.20%:结论:在百岁老人中,睡眠质量差会增加罹患高血压的风险,补体 C3 是一个中介因素。此外,夜间睡眠时间少于 6 小时或多于 9 小时会增加高 PP 风险,而淋巴细胞计数、NLR 和 SII 是诱因。
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Mediating role of inflammatory indicators in the association between sleep status and blood pressure in centenarians: evidence from China Hainan Centenarian Cohort Study.

Objectives: To conduct a comprehensive analysis in Hainan centenarians on the link between sleep status and their blood pressure status. Furthermore, the study also aims to explore how inflammatory indicators may mediate the relationship.

Methods: The China Hainan Centenarians Cohort Study (CHCCS) collected baseline data on sleep status, inflammatory indicators, and blood pressure data. The study used a mediation model to investigate how inflammatory indicators mediate the relationship between sleep status and blood pressure status.

Result: In this study, a total of 967 centenarians were included. The prevalence of hypertension among the centenarians was 71.4%. The analysis showed that centenarians with poor sleep quality had a 43% higher risk of hypertension compared to those with normal sleep quality (OR = 1.43, 95% CI: 1.03-1.97). Additionally, centenarians with nighttime sleep durations of ≤ 6 h or > 9 h had higher proportions of high pulse pressure (PP), with OR values of 1.76 (95% CI: 1.18-2.63) and 2.07 (95% CI: 1.34-3.19), respectively. Mediation analysis illustrated that complement C3 played a mediating role in the relationship between sleep quality and hypertension, with an effect ratio of 2.4%. Similarly, lymphocyte count, the neutrophil-to-lymphocyte ratio (NLR), and the systemic immune-inflammation index (SII) were identified as mediating factors in the association between nighttime sleep duration and high PP, with effect ratios of 91.22%, 36.93%, and 0.20%, respectively.

Conclusion: In centenarians, poor sleep quality raises the risk of hypertension, with complement C3 as a mediator. Additionally, nighttime sleep durations of ≤ 6 h or > 9 h increases the risk of high PP, mediated by lymphocyte count, NLR, and SII.

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来源期刊
Journal of Geriatric Cardiology
Journal of Geriatric Cardiology CARDIAC & CARDIOVASCULAR SYSTEMS-GERIATRICS & GERONTOLOGY
CiteScore
3.30
自引率
4.00%
发文量
1161
期刊介绍: JGC focuses on both basic research and clinical practice to the diagnosis and treatment of cardiovascular disease in the aged people, especially those with concomitant disease of other major organ-systems, such as the lungs, the kidneys, liver, central nervous system, gastrointestinal tract or endocrinology, etc.
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