Lu Yang, Deqian Kong, Xiuping Ma, Yi Long, Jibian Ban, Kaiqi Luo, Xianshu Wang
{"title":"制备负载有 Melastoma dodecandrum Lour.提取物的纳米纤维膜的制备","authors":"Lu Yang, Deqian Kong, Xiuping Ma, Yi Long, Jibian Ban, Kaiqi Luo, Xianshu Wang","doi":"10.1016/j.matlet.2024.137588","DOIUrl":null,"url":null,"abstract":"<div><div><em>Melastoma dodecandrum</em> Lour. is a plant with a rapid hemostatic effect that is mainly distributed in Guizhou, Guangxi, Guangdong, and other provinces in China. In this study, we prepared a new rapid hemostatic wound dressing using <em>Melastoma dodecandrum</em> Lour. extract (MDLE). Nanofiber membranes (PVA/CS/MDLE) consisting of polyvinyl alcohol (PVA), chitosan (CS), and different doses of MDLE were prepared using an electrospinning method.<!--> <!-->Then, each group of nanofiber membranes was characterized using SEM, FTIR, and XRD. The diameters of PVA/CS, PVA/CS/2.8 %-MDLE, PVA/CS/5.5 %-MDLE, and PVA/CS/8.2 %-MDLE were 207.2 ± 36.65 <!--> <!-->nm, 313.3 ± 68.14 nm, 350.0 ± 80.55 nm, and 371.1 ± 82.84 nm, respectively. PVA/CS/2.8 %-MDLE exhibited the greatest mechanical strength, while PVA/CS/5.5 %-MDLE exhibited the greatest elongation at break. PVA/CS/5.5 %-MDLE and PVA/CS/8.2 %-MDLE exhibited significant bacteriostatic effects and inhibited <em>Staphylococcus aureus</em> more effectively than <em>Escherichia coli</em>. The PVA/CS/8.2 %-MDLE group had a significant hemostatic effect (<em>P <</em> 0.001), and all groups exhibited hydrophilicity, swelling ratios, and low toxicity. As the drug concentration increased, the time required for hemostasis decreased. Overall, these findings demonstrated that the PVA/CS/MDLE has great potential as a wound dressing. To our knowledge, this is the first time that a functional nanofiber with rapid hemostasis has been successfully prepared using MDLE.</div></div>","PeriodicalId":384,"journal":{"name":"Materials Letters","volume":"378 ","pages":"Article 137588"},"PeriodicalIF":2.7000,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Preparation of a nanofiber membrane loaded with Melastoma dodecandrum Lour. Extract for rapid hemostasis\",\"authors\":\"Lu Yang, Deqian Kong, Xiuping Ma, Yi Long, Jibian Ban, Kaiqi Luo, Xianshu Wang\",\"doi\":\"10.1016/j.matlet.2024.137588\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div><em>Melastoma dodecandrum</em> Lour. is a plant with a rapid hemostatic effect that is mainly distributed in Guizhou, Guangxi, Guangdong, and other provinces in China. In this study, we prepared a new rapid hemostatic wound dressing using <em>Melastoma dodecandrum</em> Lour. extract (MDLE). Nanofiber membranes (PVA/CS/MDLE) consisting of polyvinyl alcohol (PVA), chitosan (CS), and different doses of MDLE were prepared using an electrospinning method.<!--> <!-->Then, each group of nanofiber membranes was characterized using SEM, FTIR, and XRD. The diameters of PVA/CS, PVA/CS/2.8 %-MDLE, PVA/CS/5.5 %-MDLE, and PVA/CS/8.2 %-MDLE were 207.2 ± 36.65 <!--> <!-->nm, 313.3 ± 68.14 nm, 350.0 ± 80.55 nm, and 371.1 ± 82.84 nm, respectively. PVA/CS/2.8 %-MDLE exhibited the greatest mechanical strength, while PVA/CS/5.5 %-MDLE exhibited the greatest elongation at break. PVA/CS/5.5 %-MDLE and PVA/CS/8.2 %-MDLE exhibited significant bacteriostatic effects and inhibited <em>Staphylococcus aureus</em> more effectively than <em>Escherichia coli</em>. The PVA/CS/8.2 %-MDLE group had a significant hemostatic effect (<em>P <</em> 0.001), and all groups exhibited hydrophilicity, swelling ratios, and low toxicity. As the drug concentration increased, the time required for hemostasis decreased. Overall, these findings demonstrated that the PVA/CS/MDLE has great potential as a wound dressing. To our knowledge, this is the first time that a functional nanofiber with rapid hemostasis has been successfully prepared using MDLE.</div></div>\",\"PeriodicalId\":384,\"journal\":{\"name\":\"Materials Letters\",\"volume\":\"378 \",\"pages\":\"Article 137588\"},\"PeriodicalIF\":2.7000,\"publicationDate\":\"2024-10-22\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Materials Letters\",\"FirstCategoryId\":\"88\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0167577X24017282\",\"RegionNum\":4,\"RegionCategory\":\"材料科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"MATERIALS SCIENCE, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Letters","FirstCategoryId":"88","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0167577X24017282","RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"MATERIALS SCIENCE, MULTIDISCIPLINARY","Score":null,"Total":0}
Preparation of a nanofiber membrane loaded with Melastoma dodecandrum Lour. Extract for rapid hemostasis
Melastoma dodecandrum Lour. is a plant with a rapid hemostatic effect that is mainly distributed in Guizhou, Guangxi, Guangdong, and other provinces in China. In this study, we prepared a new rapid hemostatic wound dressing using Melastoma dodecandrum Lour. extract (MDLE). Nanofiber membranes (PVA/CS/MDLE) consisting of polyvinyl alcohol (PVA), chitosan (CS), and different doses of MDLE were prepared using an electrospinning method. Then, each group of nanofiber membranes was characterized using SEM, FTIR, and XRD. The diameters of PVA/CS, PVA/CS/2.8 %-MDLE, PVA/CS/5.5 %-MDLE, and PVA/CS/8.2 %-MDLE were 207.2 ± 36.65 nm, 313.3 ± 68.14 nm, 350.0 ± 80.55 nm, and 371.1 ± 82.84 nm, respectively. PVA/CS/2.8 %-MDLE exhibited the greatest mechanical strength, while PVA/CS/5.5 %-MDLE exhibited the greatest elongation at break. PVA/CS/5.5 %-MDLE and PVA/CS/8.2 %-MDLE exhibited significant bacteriostatic effects and inhibited Staphylococcus aureus more effectively than Escherichia coli. The PVA/CS/8.2 %-MDLE group had a significant hemostatic effect (P < 0.001), and all groups exhibited hydrophilicity, swelling ratios, and low toxicity. As the drug concentration increased, the time required for hemostasis decreased. Overall, these findings demonstrated that the PVA/CS/MDLE has great potential as a wound dressing. To our knowledge, this is the first time that a functional nanofiber with rapid hemostasis has been successfully prepared using MDLE.
期刊介绍：
Materials Letters has an open access mirror journal Materials Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review.
Materials Letters is dedicated to publishing novel, cutting edge reports of broad interest to the materials community. The journal provides a forum for materials scientists and engineers, physicists, and chemists to rapidly communicate on the most important topics in the field of materials.
Contributions include, but are not limited to, a variety of topics such as:
• Materials - Metals and alloys, amorphous solids, ceramics, composites, polymers, semiconductors
• Applications - Structural, opto-electronic, magnetic, medical, MEMS, sensors, smart
• Characterization - Analytical, microscopy, scanning probes, nanoscopic, optical, electrical, magnetic, acoustic, spectroscopic, diffraction
• Novel Materials - Micro and nanostructures (nanowires, nanotubes, nanoparticles), nanocomposites, thin films, superlattices, quantum dots.
• Processing - Crystal growth, thin film processing, sol-gel processing, mechanical processing, assembly, nanocrystalline processing.
• Properties - Mechanical, magnetic, optical, electrical, ferroelectric, thermal, interfacial, transport, thermodynamic
• Synthesis - Quenching, solid state, solidification, solution synthesis, vapor deposition, high pressure, explosive
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