聚（乙烯亚胺）树枝状聚合物表面 PEG 化接枝磁性纳米粒子作为一种用于阿糖胞苷给药的 pH 值和磁性靶向响应系统

IF 2.8 3区化学 Q3 CHEMISTRY, PHYSICAL Chemical Physics Letters Pub Date : 2024-10-24 DOI:10.1016/j.cplett.2024.141722

Saeed Falah Mashak , Elham Moniri , Fatemeh Azarakhshi , Shadab Shahsavari , Niloufar Torabi Fard

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摘要

通过对接枝磁性纳米粒子的聚（乙烯亚胺）树枝状聚合物进行 PEG 化，合成了一种用于靶向递送阿糖胞苷的 pH 和磁性双重响应平台。表征技术证实了该平台的结构和特性。在 pH 值为 8、吸附剂用量为 0.01 克、接触时间为 60 分钟、温度为 298 K 的条件下，药物吸附效果最佳。热力学数据表明，药物吸附是一个有利的自发过程。在 pH 值为 5.6 和 7.4 的条件下，药物释放率在 6 小时内分别为 61.45% 和 21.92%。

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Surface PEGylation of Poly(Ethylenimine) dendrimers grafted magnetic nanoparticles as a pH and magnetic targeting responsive system for Cytarabine drug delivery

A pH and magnetically dual responsive platform was synthesized by PEGylation of poly (ethylenimine) dendrimers grafted magnetic nanoparticles for targeted cytarabine delivery. Characterization techniques confirmed the platform structure and properties. Optimal drug adsorption occurred at pH 8, with an adsorbent dosage of 0.01 g, and 60 min of contact time at 298 K. Pseudo-second-order kinetic and Langmuir isotherm models best fit the adsorption data. The thermodynamic data shows that drug adsorption is a favorable and spontaneous process. Drug release rates were 61.45 % and 21.92 % at pH 5.6 and 7.4 over 6 h. The release kinetics followed Korsmeyer-Peppas model, showing non-Fickian behavior.

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来源期刊

Chemical Physics Letters 化学-物理：原子、分子和化学物理

CiteScore

5.70

自引率

3.60%

发文量

798

审稿时长

33 days

期刊介绍： Chemical Physics Letters has an open access mirror journal, Chemical Physics Letters: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. Chemical Physics Letters publishes brief reports on molecules, interfaces, condensed phases, nanomaterials and nanostructures, polymers, biomolecular systems, and energy conversion and storage. Criteria for publication are quality, urgency and impact. Further, experimental results reported in the journal have direct relevance for theory, and theoretical developments or non-routine computations relate directly to experiment. Manuscripts must satisfy these criteria and should not be minor extensions of previous work.