Jingxin Hou , Cong Hu , Hanyin Li , Hongmei Liu , Yangjiayi Xiang , Gou Wu , Yan Li
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Nanomaterial-based magnetic solid-phase extraction in pharmaceutical and biomedical analysis
Magnetic solid-phase extraction (MSPE) holds significant scientific and technological interest as a novel sample preparation method for complex samples due to its easy operation, swift separation, high adsorption efficiency, and environmental friendliness. As the core of MSPE, magnetic sorbents have captured tremendous attention in recent years. Various promising nanomaterials, such as metal-organic frameworks and covalent organic frameworks, have been synthesized and utilized as sorbents in pharmaceutical and biomedical analysis. This review intends to (1) summarize recent progress of magnetic sorbents applied in this area and discuss their advantages, disadvantages, possible interaction mechanisms with the target substances; (2) explore their innovative applications in the analysis of pharmaceuticals, proteins, peptides, nucleic acids, nucleosides, metabolites, and other disease biomarkers from 2021 to 2024; (3) present the integration of MSPE with emerging analytical technologies; and (4) discuss the current challenges and future perspectives. It is expected to provide references and insights for the development of novel magnetic sorbents and their applications in bioanalysis.
期刊介绍：
This journal is an international medium directed towards the needs of academic, clinical, government and industrial analysis by publishing original research reports and critical reviews on pharmaceutical and biomedical analysis. It covers the interdisciplinary aspects of analysis in the pharmaceutical, biomedical and clinical sciences, including developments in analytical methodology, instrumentation, computation and interpretation. Submissions on novel applications focusing on drug purity and stability studies, pharmacokinetics, therapeutic monitoring, metabolic profiling; drug-related aspects of analytical biochemistry and forensic toxicology; quality assurance in the pharmaceutical industry are also welcome.
Studies from areas of well established and poorly selective methods, such as UV-VIS spectrophotometry (including derivative and multi-wavelength measurements), basic electroanalytical (potentiometric, polarographic and voltammetric) methods, fluorimetry, flow-injection analysis, etc. are accepted for publication in exceptional cases only, if a unique and substantial advantage over presently known systems is demonstrated. The same applies to the assay of simple drug formulations by any kind of methods and the determination of drugs in biological samples based merely on spiked samples. Drug purity/stability studies should contain information on the structure elucidation of the impurities/degradants.
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