农药接触及其与帕金森病的关系:病例对照分析

IF 3.6 4区 医学 Q3 CELL BIOLOGY Cellular and Molecular Neurobiology Pub Date : 2024-11-01 DOI:10.1007/s10571-024-01501-5
Ali Samareh, Hossein Pourghadamyari, Mohammad Hadi Nemtollahi, Hossein Ali Ebrahimi Meimand, Mohammad Erfan Norouzmahani, Gholamreza Asadikaram
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引用次数: 0

摘要

帕金森病(PD)是一种由遗传和环境因素引起的复杂疾病。目前的调查致力于研究暴露于有机氯(OCP)和有机磷农药(OPP)这两种公认的主要环境因素在帕金森病发病中的作用。在这项病例对照研究中,共有 29 名帕金森氏症患者和 51 名健康受试者参与。研究人员采用气相色谱法测量了血清中有机氯化学物质(2,4-DDT、4,4-DDT、2,4-DDE、4,4-DDE、α-HCH、β-HCH 和 γ-HCH)的含量。此外,还评估了乙酰胆碱酯酶(AChE)活性、副氧自由基酶-1(PON-1)的芳酯酶活性以及几种氧化应激(OS)指标。帕金森氏症患者的氧化应激物质水平明显高于对照组。此外,PD 患者的 AChE 活性、PON-1 的芳基酯酶活性、过氧化氢酶活性和超氧化物歧化酶 3 活性均明显低于对照组。然而,羰基蛋白、总抗氧化能力、丙二醛和一氧化氮的水平在帕金森病患者中却高于对照组。这项研究结果表明,接触 OCPs 和 OPPs 可能会导致帕金森病的发生。这种潜在的联系可能是通过这些农药对神经系统的直接影响而导致神经中毒,也可能是通过触发操作系统的间接途径而建立的。
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Pesticide Exposure and Its Association with Parkinson's Disease: A Case-Control Analysis.

Parkinson's disease (PD) is a complex disorder that arises from genetic and environmental factors. The current investigation endeavors to investigate the role of exposure to organochlorine (OCPs) and organophosphate pesticides (OPPs), recognized as the main environmental elements, in the genesis of PD. In this case-control study, 29 PD patients and 51 healthy subjects were involved. Gas chromatography was performed to measure the serum levels of organochlorine chemicals (2,4-DDT, 4,4-DDT, 2,4-DDE, 4,4-DDE, α-HCH, β-HCH, and γ-HCH). Furthermore, acetylcholinesterase (AChE) activity, arylesterase activity of paraoxonase-1 (PON-1), and several oxidative stress (OS) markers were assessed. The levels of OCPs in the PD patients were significantly higher than in the control subjects. In addition, AChE activity, arylesterase activity of PON-1, catalase activity, and superoxide dismutase 3 activity in PD patients were significantly less than controls. However, the levels of carbonyl protein, total antioxidant capacity, malondialdehyde, and nitric oxide in PD patients were higher than the controls. The findings of this investigation have indicated that OCPs and OPPs exposure could contribute to the development of Parkinson's disease. This potential linkage could either be established through the direct impact of these pesticides on the nervous system, leading to neurotoxicity, or via an indirect route through the triggering of OS.

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来源期刊
CiteScore
7.70
自引率
0.00%
发文量
137
审稿时长
4-8 weeks
期刊介绍: Cellular and Molecular Neurobiology publishes original research concerned with the analysis of neuronal and brain function at the cellular and subcellular levels. The journal offers timely, peer-reviewed articles that describe anatomic, genetic, physiologic, pharmacologic, and biochemical approaches to the study of neuronal function and the analysis of elementary mechanisms. Studies are presented on isolated mammalian tissues and intact animals, with investigations aimed at the molecular mechanisms or neuronal responses at the level of single cells. Cellular and Molecular Neurobiology also presents studies of the effects of neurons on other organ systems, such as analysis of the electrical or biochemical response to neurotransmitters or neurohormones on smooth muscle or gland cells.
期刊最新文献
Wnt-5a Signaling Mediates Metaplasticity at Hippocampal CA3-CA1 Synapses in Mice. Spinal Muscular Atrophy: Current Medications and Re-purposed Drugs. Synergistic Epistasis and Systems Biology Approaches to Uncover a Pharmacogenomic Map Linked to Pain, Anti-Inflammatory and Immunomodulating Agents (PAIma) in a Healthy Cohort. Pesticide Exposure and Its Association with Parkinson's Disease: A Case-Control Analysis. Cognitive Impact of Neurotropic Pathogens: Investigating Molecular Mimicry through Computational Methods.
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