韩国养猪场分离出的金黄色葡萄球菌的遗传特征和抗菌药耐药性:CFR 阳性 CC398 菌系的出现。

IF 2.3 2区 农林科学 Q1 VETERINARY SCIENCES BMC Veterinary Research Pub Date : 2024-11-01 DOI:10.1186/s12917-024-04360-w
Jun Bong Lee, Ji Hyun Lim, Ji Heon Park, Gi Yong Lee, Kun Taek Park, Soo-Jin Yang
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引用次数: 0

摘要

背景:家畜相关金黄色葡萄球菌(LA-SA)已引起全球关注,因为它能够在农场动物中定植并传播给环境和人类,导致症状性感染和抗菌药耐药性(AMR)的传播。在过去十年中,许多研究都报道了金黄色葡萄球菌克隆复合体(CC)398 在养猪场的高流行率:本研究从健康猪(n = 110)、猪场环境(n = 42)和猪场工人(n = 11)中收集了 163 株金葡菌分离物,并对其 AMR 图谱和流行病学特征进行了分析。我们发现了 51 株(31.3%)耐甲氧西林金黄色葡萄球菌(MRSA)和 112 株(68.7%)甲氧西林易感金黄色葡萄球菌(MSSA),其中 161 株(98.8%)属于 CC398 菌系。在 CC398 分离物中,t571 型 spa 的流行率最高。所有 47 个序列类型(ST)398 MRSA 分离物都携带葡萄球菌盒式染色体mec(SCCmec)V,而 4 个 ST541 分离物携带 SCCmec IV。在韩国的养猪场发现,对常用抗生素(包括酚类、喹诺酮类、林可酰胺类、大环内酯类、氨基糖苷类和四环素类)的耐药性很高。值得注意的是,在健康猪体内发现了 21 个 cfr 阳性 CC398 分离物(4 个 ST541-SCCmec IV MRSA 和 17 个 ST398 MSSA),它们对利奈唑胺的耐药性增强:总之,这些研究结果表明,耐多药 CC398 金黄色葡萄球菌菌系主要定植于韩国的健康猪和农场环境中。在人与动物交界处出现的 cfr 阳性金黄色葡萄球菌对食品安全和公共卫生构成了重大威胁。
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Genetic characteristics and antimicrobial resistance of Staphylococcus aureus isolates from pig farms in Korea: emergence of cfr-positive CC398 lineage.

Background: Livestock-associated Staphylococcus aureus (LA-SA) has gained global attention because of its ability to colonize farm animals and transmit to the environment and humans, leading to symptomatic infections and the spread of antimicrobial resistance (AMR). In the last decade, numerous studies have reported a high prevalence of S. aureus clonal complex (CC) 398 in pig farms.

Results: In this study, 163 S. aureus isolates were collected from healthy pigs (n = 110), farm environments (n = 42), and farm workers (n = 11), and their AMR profiles and epidemiological characteristics were analyzed. We identified 51 (31.3%) methicillin-resistant S. aureus (MRSA) and 112 (68.7%) methicillin-susceptible S. aureus (MSSA), with 161 (98.8%) isolates belonging to the CC398 lineage. The highest prevalence of spa type t571 was observed among the CC398 isolates. All 47 sequence type (ST) 398 MRSA isolates carried staphylococcal cassette chromosome mec (SCCmec) V, while four ST541 isolates carried SCCmec IV. High levels of resistance to commonly used antibiotics, including phenicols, quinolones, lincosamides, macrolides, aminoglycosides, and tetracyclines, have been observed on Korean pig farms. Notably, 21 cfr-positive CC398 isolates (four ST541-SCCmec IV MRSA and 17 ST398 MSSA) displaying increased resistance to linezolid were identified in healthy pigs.

Conclusions: In summary, these findings suggest that the multidrug-resistant CC398 S. aureus lineage predominantly colonizes healthy pigs and farm environments in Korea. The emergence of cfr-positive S. aureus at human-animal interfaces presents a significant threat to food safety and public health.

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来源期刊
BMC Veterinary Research
BMC Veterinary Research VETERINARY SCIENCES-
CiteScore
4.80
自引率
3.80%
发文量
420
审稿时长
3-6 weeks
期刊介绍: BMC Veterinary Research is an open access, peer-reviewed journal that considers articles on all aspects of veterinary science and medicine, including the epidemiology, diagnosis, prevention and treatment of medical conditions of domestic, companion, farm and wild animals, as well as the biomedical processes that underlie their health.
期刊最新文献
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