{"title":"将抑制内皮细胞增殖作为遗传性出血性毛细血管扩张症的一种潜在治疗方法。","authors":"Nicolas Ricard, Sabine Bailly","doi":"10.1038/s44161-024-00557-2","DOIUrl":null,"url":null,"abstract":"Arteriovenous malformations are the hallmark of patients with hereditary hemorrhagic telangectasia. Research now finds that this could be due to endothelial cell-cycle acceleration via CDK6. These results could suggest repurposing CDK6 inhibitors for this disorder.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 11","pages":"1267-1269"},"PeriodicalIF":9.4000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Inhibition of endothelial cell proliferation as a potential therapeutic approach in hereditary hemorrhagic telangectasia\",\"authors\":\"Nicolas Ricard, Sabine Bailly\",\"doi\":\"10.1038/s44161-024-00557-2\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Arteriovenous malformations are the hallmark of patients with hereditary hemorrhagic telangectasia. Research now finds that this could be due to endothelial cell-cycle acceleration via CDK6. These results could suggest repurposing CDK6 inhibitors for this disorder.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"3 11\",\"pages\":\"1267-1269\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00557-2\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00557-2","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
Inhibition of endothelial cell proliferation as a potential therapeutic approach in hereditary hemorrhagic telangectasia
Arteriovenous malformations are the hallmark of patients with hereditary hemorrhagic telangectasia. Research now finds that this could be due to endothelial cell-cycle acceleration via CDK6. These results could suggest repurposing CDK6 inhibitors for this disorder.
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