Elizabeth S Dhummakupt, Conor C Jenkins, Gabrielle M Rizzo, Allison E Clay, Jennifer R Horsmon, Tyler D P Goralski, Julie A Renner, Daniel J Angelini
{"title":"对暴露于路易斯特的人体真皮等效组织进行多组学分析。","authors":"Elizabeth S Dhummakupt, Conor C Jenkins, Gabrielle M Rizzo, Allison E Clay, Jennifer R Horsmon, Tyler D P Goralski, Julie A Renner, Daniel J Angelini","doi":"10.1016/j.cbi.2024.111295","DOIUrl":null,"url":null,"abstract":"<p><p>Lewisite (Military Code: L) is an arsenical vesicant chemical warfare agent (CWA) that was developed in the United States during World War I. Even though its use has not been documented in warfare, large stockpiles were created and still exist in various locations around the world. Given that large quantities exist as well as the relative straightforward process for its creation, Lewisite still presents itself as a serious threat agent. In this study, we examined the effects of Lewisite on human dermal equivalent tissues (EpiDerm™/EpiDerm™-FT) through the evaluation of cellular viability, histology, and multiomic analysis.</p>","PeriodicalId":93932,"journal":{"name":"Chemico-biological interactions","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Multiomic analysis of Lewisite exposed human dermal equivalent tissues.\",\"authors\":\"Elizabeth S Dhummakupt, Conor C Jenkins, Gabrielle M Rizzo, Allison E Clay, Jennifer R Horsmon, Tyler D P Goralski, Julie A Renner, Daniel J Angelini\",\"doi\":\"10.1016/j.cbi.2024.111295\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Lewisite (Military Code: L) is an arsenical vesicant chemical warfare agent (CWA) that was developed in the United States during World War I. Even though its use has not been documented in warfare, large stockpiles were created and still exist in various locations around the world. Given that large quantities exist as well as the relative straightforward process for its creation, Lewisite still presents itself as a serious threat agent. In this study, we examined the effects of Lewisite on human dermal equivalent tissues (EpiDerm™/EpiDerm™-FT) through the evaluation of cellular viability, histology, and multiomic analysis.</p>\",\"PeriodicalId\":93932,\"journal\":{\"name\":\"Chemico-biological interactions\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-10-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Chemico-biological interactions\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1016/j.cbi.2024.111295\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Chemico-biological interactions","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1016/j.cbi.2024.111295","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Multiomic analysis of Lewisite exposed human dermal equivalent tissues.
Lewisite (Military Code: L) is an arsenical vesicant chemical warfare agent (CWA) that was developed in the United States during World War I. Even though its use has not been documented in warfare, large stockpiles were created and still exist in various locations around the world. Given that large quantities exist as well as the relative straightforward process for its creation, Lewisite still presents itself as a serious threat agent. In this study, we examined the effects of Lewisite on human dermal equivalent tissues (EpiDerm™/EpiDerm™-FT) through the evaluation of cellular viability, histology, and multiomic analysis.
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