Chemico-Biological Interactions最新文献

{"title":"Withaferin-A induced vimentin S56 phosphorylation dissociates NEDD9 signaling loop to regress progressive metastatic melanoma into lung adenocarcinoma","authors":"Ankith Sherapura ,&nbsp;B.K. Kiran ,&nbsp;G.S. Pavan Kumar ,&nbsp;B.M. Siddesh ,&nbsp;Prabhu Thirusangu ,&nbsp;N. Suchetha Kumari ,&nbsp;B.T. Prabhakar","doi":"10.1016/j.cbi.2024.111319","DOIUrl":"10.1016/j.cbi.2024.111319","url":null,"abstract":"<div><div>Metastasis is complex and insidious type of disease involves multiple signaling nexus, which have implications in understanding disease pathogenesis. Treatment failure for metastatic cancer is frequently high due to aggressive adaptation of cancerous cells to invade to neighboring organs. Cytoskeleton intermediate filamentous protein <em>Vimentin</em> and scaffolding protein <em>Neural precursor cell expressed Developmentally Down-regulated protein 9 (NEDD9)</em> play a key role in metastatic events by regulating multiple metastatic events. Interaction between these proteins is necessary to promote metastatic progression. Withaferin A (WFA), a natural pharamacophore, known to target <em>Vimentin</em> to induce antitumor potential. However exact molecular mechanism still yet to be elucidated. We hypothesize, <em>Vimentin-</em>NEDD9 signaling nexus is necessary for metastatic progression and targeting this interwoven signaling loop with effective pharamacophore WFA halts metastatic progression of melanoma into lung. To elucidate the same, we carried out gene expression measurement through quantitative Reverses Transcription Polymerase Chain Reaction (qRT-PCR), Immunoblot and Immunohistochemistry. Assessment of interactive signaling by Co-immunoprecipitation, Immunofluorescence, Co-localization and Proximity ligation assay. Phosphorylation studies through transfection of phospho specific mutant constructs generated through site directed mutagenesis. WFA induced cellular behavioral changes by migration, invasion assays and Immunoblot analysis. The B16F10 induced mouse metastatic melanoma model to asses <em>NEDD9-Vimentin</em> expression and anti-metastasis induced by WFA. The results postulates, elevated levels and interaction between <em>NEDD9-Vimentin</em> proteins, have positive correlation in metastatic progression of melanoma into lung in both <em>in-vitro</em> and <em>in-vivo</em> condition, establishing it as therapeutic target. Pharmacologically, WFA targets this complex by extending its activity by not only inducing specific Serine 56 phosphorylation of <em>Vimentin</em>, also dissociates <em>NEDD9</em> signaling loop to halt Epithelial-mesenchymal transition (EMT) and subsequent metastatic events. Eventually, modulation of the relevant metastatic genes <em>E-Cadherin, N-Cadherin, SNAIL, MMP-2 &amp; MMP-9</em> resulted in regression of metastatic melanoma progression to lung. The study validates WFA induced S56 phosphorylation is necessary to abrupt the <em>NEDD9-Vimentin</em> metastatic signaling complex to regress aggressive metastatic melanoma. The investigation emphasized more mechanistic approach of WFA. Understanding and targeting such integrative mechanical input in the tumor microenvironment will be a better therapeutic strategy to combat metastasis.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"406 ","pages":"Article 111319"},"PeriodicalIF":4.7,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142756049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Schwann cells exposed to articaine display distinct toxic pathways compared to lidocaine","authors":"Gustavo H. Rodrigues da Silva ,&nbsp;Luís F. Mendes ,&nbsp;Gabriela Geronimo ,&nbsp;Ludmilla D. de Moura ,&nbsp;Juliana S. Ruas ,&nbsp;Roger F. Castilho ,&nbsp;Helon G. Cordeiro ,&nbsp;Carmen V. Ferreira ,&nbsp;Eneida de Paula ,&nbsp;Iola F. Duarte","doi":"10.1016/j.cbi.2024.111315","DOIUrl":"10.1016/j.cbi.2024.111315","url":null,"abstract":"<div><div>Articaine (ATC) has emerged as one of the most popular local anesthetics (LA) in dental clinics, despite its relatively recent introduction to the market. As a member of the amino-amide class of LA, ATC possesses unique features, including a thiophene ring and an ester group, which allow for its use at higher clinical concentrations. However, reports have indicated a higher incidence of paresthesia associated with ATC, though the underlying cause of this effect remains unclear. To investigate this further, we conducted an extracellular metabolic flux analysis and an NMR-based metabolomics study of ATC effects on Schwann cells - a type of glial cell found in the peripheral nervous system - in comparison to lidocaine (LDC), the “gold standard\" LA in dentistry. The results showed that ATC had a more significant impact on Schwann cell oxygen consumption compared to LDC. Metabolomics profiling of Schwann cells revealed distinct metabolic alterations between the two treatments. Notably, ATC triggered elevated intracellular levels of various amino acids, including leucine, isoleucine, valine, phenylalanine, methionine, histidine, tyrosine, and glycine, which were not observed in LDC-treated Schwann cells. This was consistent with signs of endoplasmic reticulum stress and apoptosis in ATC-treated cells, as detected by protein expression analysis. These findings offer insights into the metabolic and cellular responses elicited by the two anesthetics in Schwann cells, that may help explain the differential toxicity and higher incidence of paresthesia associated with ATC.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"406 ","pages":"Article 111315"},"PeriodicalIF":4.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nano-scale dangers: Unravelling the impact of nanoplastics on human trophoblast invasion","authors":"Mirjana Nacka-Aleksić ,&nbsp;Aleksandra Vilotić ,&nbsp;Andrea Pirković ,&nbsp;Marko Živanović ,&nbsp;Biljana Ljujić ,&nbsp;Milica Jovanović Krivokuća","doi":"10.1016/j.cbi.2024.111317","DOIUrl":"10.1016/j.cbi.2024.111317","url":null,"abstract":"<div><div>Utilizing HTR-8/SVneo cells for <em>in vitro</em> modeling of human trophoblast invasion, we examined how different concentrations of 40 nm and 200 nm carboxylated polystyrene particles affect early-pregnancy trophoblast phenotype and function. We focused on migration and invasion, as critical processes in placental development. Our findings revealed disruptions in extravillous trophoblast mesenchymal phenotype and invasive behavior, following acute exposure to a higher concentration of the smaller sized particles. Specifically, differential uptake of the particles by trophoblast cells was observed, as well as cytotoxicity and concentration-dependent DNA damage after 72 h of exposure. In addition, a 24 h exposure to 100 μg/ml of 40 nm particles correlated with downregulated protein expression of α5 and α1 integrin subunits, N-cadherin, matrix metalloproteinase-2 and macrophage migration inhibitory factor, alongside upregulated protein expression of the epithelial marker E-cadherin. These changes likely contributed to the diminished migration of HTR-8/SVneo cells and the invasive potential of HTR-8/SVneo spheroids. Understanding these interactions is paramount for assessing the broader implications of nanoplastics on reproductive outcomes and maternal-fetal well-being and informing public health measures.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111317"},"PeriodicalIF":4.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chitooligosaccharide-epigallocatechin gallate conjugate ameliorates lipid accumulation and promotes browning of white adipose tissue in high fat diet fed rats","authors":"Kanokrada Tonphu ,&nbsp;Sirikul Mueangaun ,&nbsp;Natcha Lerkdumnernkit ,&nbsp;Jirakhamon Sengking ,&nbsp;Jiraporn Tocharus ,&nbsp;Soottawat Benjakul ,&nbsp;Ajay Mittal ,&nbsp;Chainarong Tocharus","doi":"10.1016/j.cbi.2024.111316","DOIUrl":"10.1016/j.cbi.2024.111316","url":null,"abstract":"<div><div>The prevalence of obesity has increased progressively worldwide. Obesity is characterized by excessive accumulation of fat in adipose tissues, leading to metabolic impairment. The anti-obese effects of chitooligosaccharide (COS) and epigallocatechin-3-gallate (EGCG) have been extensively clarified. This study aimed to investigate the effects and potential mechanisms of the COS-EGCG conjugate (CE) on anti-obesity, specifically by alleviating lipid accumulation and promoting the browning of white adipose tissue (WAT) in obese rats. Obesity as a consequence of a high-fat diet (HFD) was induced in male Wistar rats. The HFD was given for 16 weeks and the rats were then randomly subdivided into five groups namely: vehicle (control group), HFD plus CE at 150 mg/kg/day, HFD plus CE at 600 mg/kg/day, HFD plus COS at 600 mg/kg/day, and HFD plus atorvastatin at 10 mg/kg/day for 4 weeks. CE could reduce body weight, improve serum lipid profiles, and promote lipid metabolism via activation of AMP-activated protein kinase (AMPK) in WAT and enhance the processes of WAT browning by activating sirtuin 1 (Sirt 1), peroxisome proliferator-activated receptor-gamma coactivator (PGC1-α), and uncoupling the protein 1 (UCP1) signaling pathway. CE reduced obesity and promoted WAT browning in HFD-fed rats. Therefore, CE might be a new therapy for metabolic syndrome and obesity.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"406 ","pages":"Article 111316"},"PeriodicalIF":4.7,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142694028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Glycerophospholipid metabolic disorders and gender difference of cantharidin-induced hepatotoxicity in rats: Lipidomics and MALDI mass spectrometry imaging analysis","authors":"Qiyi Wang ,&nbsp;Weina Cheng ,&nbsp;Tianmu He ,&nbsp;Shan Li ,&nbsp;Jingwen Ao ,&nbsp;Yanmei He ,&nbsp;Cancan Duan ,&nbsp;Xiaofei Li ,&nbsp;Jianyong Zhang","doi":"10.1016/j.cbi.2024.111314","DOIUrl":"10.1016/j.cbi.2024.111314","url":null,"abstract":"<div><div>The hepatotoxicity mechanism of cantharidin (CTD), a major active component of <em>Mylabris</em> was explored based on liver lipidome alterations and spatial distributions in female and male rats using lipidomics and matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI). After oral CTD exposure, the livers of female rats were screened for 104 differential lipids including lysophosphatidylethanolamine(LysoPE)(20:2/0:0) and diacylglycerol(DG)(18:2/22:4), whereas the livers of male rats were screened for 76 differential lipids including fatty acid(FA)(24:6) and DG(18:0/22:4). According to the MALDI-MSI results, female rats exhibited 12 differential lipids with alteration in the abundance and spatial distribution of phosphatylcholine(PC), phosphatidylethanolamine(PE), lysophosphatidylcholine(LysoPC), and LysoPE in the liver lesion area. On the other hand, male rats exhibited 8 differential lipids with changes in the abundance and spatial distribution of PC, PE, and FA in the liver lesion area. The lipidomics- and MALDI-MSI-detected differential lipids strongly disrupted glycerophospholipid metabolism in both female and male rats. Additionally, phosphatidate phosphatase <strong>(</strong>Lipin1), choline/ethanolamine phosphotransferase 1 (CEPT1), and phosphatidylethanolamine N-methyltransferase (PEMT) were screened to distinguish CTD hepatoxicity in female and male rats. Western blotting analysis demonstrated a significant elevation in Lipin1 expression in female and male rat livers, accompanied by a decrease in PEMT expression. Furthermore, CEPT1 expression increased significantly in female rat livers and decreased significantly in male rat livers. These findings suggested that CTD could disrupt lipid metabolism in a gender-specific manner. Moreover, the combination of lipidomics and MALDI-MSI could offer valuable insights into CTD-induced hepatotoxicity in rats.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111314"},"PeriodicalIF":4.7,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delavinone elicits oxidative stress and triggers ferroptosis in colorectal cancer by inhibiting PKCδ-mediated phosphorylation of Nrf2","authors":"Ya Zhang ,&nbsp;Xiexiao Cai ,&nbsp;Xiaojing Ma ,&nbsp;Huanjuan Yan ,&nbsp;Qifang Wu ,&nbsp;Haibin Tong ,&nbsp;Zhihai Zheng","doi":"10.1016/j.cbi.2024.111312","DOIUrl":"10.1016/j.cbi.2024.111312","url":null,"abstract":"<div><div>Ferroptosis is a potential therapeutic approach for colorectal cancer (CRC). Studies have shown that peimine and its analogs exhibit anti-cancer potential; however, the intricate relationship between ferroptosis and their efficacy in fighting CRC remains unclear. In this study, we attempted to assess the therapeutic impact of peimine and its analogs on CRC and unravel the underlying mechanisms. CRC cells and a DSS/AOM-induced CRC mouse model were employed for <em>in vitro</em> and <em>in vivo</em> experiments, molecular interactions and co-immunoprecipitation were used to identify target proteins. Among the compounds, delavinone significantly inhibited CRC cell proliferation and increased cellular lipid ROS levels, MDA accumulation, and GSH depletion; the ferroptosis inhibitors DFO and Fer-1 ameliorated delavinone-induced cell death. Mechanistically, delavinone impedes PKCδ-mediated Nrf2 phosphorylation by inhibiting the kinase activity of PKCδ, thereby decreasing Nrf2 nuclear translocation and downstream GSH synthesis-related gene expression. overexpression of GPX4 weakened the anticancer effect of delavinone, underscoring delavinone's inhibition of the PKCδ/Nrf2/GPX4 signaling axis and induction of ferroptosis in CRC cells. Consistent with <em>in vitro</em> findings, delavinone notably hindered AOM/DSS-induced colorectal carcinogenesis, exhibiting a pronounced pro-ferroptosis effect on CRC. This study delineates that delavinone exerts its anticancer activity by inducing ferroptosis through PKCδ inhibition, consequently reducing Nrf2 phosphorylation. These findings position delavinone as a promising candidate for CRC treatment.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111312"},"PeriodicalIF":4.7,"publicationDate":"2024-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Copper oxide nanoparticles induced reactive oxygen species generation: A systematic review and meta-analysis","authors":"Srimathi Murugesan,&nbsp;Satheeswaran Balasubramanian,&nbsp;Ekambaram Perumal","doi":"10.1016/j.cbi.2024.111311","DOIUrl":"10.1016/j.cbi.2024.111311","url":null,"abstract":"<div><div>Copper oxide nanoparticles (CuO NPs) are widely employed in various industrial and biomedical applications owing to their enhanced physicochemical characteristics. However, concerns regarding their adverse effects on biological systems upon entering the environment remain unexplored. The generation of reactive oxygen species (ROS) is one of the primary mechanisms in CuO NPs induced toxicity. This meta-analysis was conducted to assess the associative link between CuO NPs exposure and ROS generation. A literature survey was performed in PubMed, Web of Science, Scopus, and Google Scholar, following PRISMA guidelines. After comprehensive initial and primary screening, 28 <em>in vitro</em> studies were selected for meta-analysis. Overall, our results show a substantial increase of ROS in the experimental group when compared to control (SMD = 3.3; 95 % CI: 2.82−3.77, p = 0.00001), with substantial heterogeneity (82 %). Subgroup analysis revealed that larger-sized NPs, higher dosages, and longer exposure duration were associated with ROS generation. Meta-regression analysis identified size, and dosage as significant factors influencing ROS levels. Sensitivity analysis revealed an outlier study and the funnel plot results suggested potential publication bias. Overall, our results provide valuable insights of CuO NPs induced ROS generation, and the relation of variables such as size, dose, and duration in nanotoxicity assessments.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111311"},"PeriodicalIF":4.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the nephrotoxicity and molecular mechanisms of Di-2-ethylhexyl phthalate: A comprehensive review","authors":"Yun Liu ,&nbsp;Xu Zhang ,&nbsp;Ruhan Yi ,&nbsp;Qing Tian ,&nbsp;Jiawei Xu ,&nbsp;Xinyu Yan ,&nbsp;Jiaxuan Ma ,&nbsp;Shaopeng Wang ,&nbsp;Guang Yang","doi":"10.1016/j.cbi.2024.111310","DOIUrl":"10.1016/j.cbi.2024.111310","url":null,"abstract":"<div><div>Di-2-ethylhexyl phthalate (DEHP), a widely applied plasticizer in various products, can be absorbed into the human body through several channels and accumulate in the lungs, liver, testes, and kidneys, potentially impairing the function of these organs. Recently, the nephrotoxicity of DEHP has received heightened attention. Numerous epidemiologic findings have demonstrated that DEHP exposure may contribute to renal damage, leading to structural and functional abnormalities and exacerbating the progression of kidney disease. Recent research has discovered the mechanisms behind DEHP-induced nephrotoxicity may involve a variety of pathways, including apoptosis, autophagy, ferroptosis, oxidative stress, inflammation, DNA damage, and lipid metabolism disorders. This review discusses the impact of DEHP on kidney function and delves into the molecular mechanisms of nephrotoxicity mediated by DEHP in recent years. In addition, the review examines evidence for the antioxidant and anti-inflammatory capacities of lycopene, green tea polyphenols, and quercetin in ameliorating DEHP-induced renal injury is reviewed, providing a basis for further research.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111310"},"PeriodicalIF":4.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142645334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Biphasic effect of limonene on contraction of isolated rat aorta","authors":"Renata Evaristo Rodrigues da Silva ,&nbsp;Luís Pereira-de-Morais ,&nbsp;Andressa de Alencar Silva ,&nbsp;Carla Mikevely de Sena Bastos ,&nbsp;Emanuel Kennedy-Feitosa ,&nbsp;Irwin Rose Alencar de Menezes ,&nbsp;Daniel Weinreich ,&nbsp;José Henrique Leal-Cardoso ,&nbsp;Roseli Barbosa","doi":"10.1016/j.cbi.2024.111313","DOIUrl":"10.1016/j.cbi.2024.111313","url":null,"abstract":"<div><div>Limonene, a monoterpene found in essential oils, has various activities, such as antifungal, antioxidant, neuroprotective, gastroprotective and vasorelaxant. However, the observation of limonene's biphasic effect in preclinical studies provides crucial information about its dose-dependent actions. Understanding this behavior is essential for optimizing therapeutic doses and anticipating possible side effects prior to clinical trials. The objective of this study is to provide a more detailed characterization and investigation of the mechanisms of action of limonene on the contractile tonus of isolated aorta.The experiments were carried out on aortic rings isolated from rats, subjected to isometric recording of contractions in their circular smooth muscle and exposed to different concentrations of limonene. It was found that limonene blocked the contraction induced by KCl (60 mM), but had a biphasic effect on the contraction induced by phenylephrine (0.1 μM). At lower concentrations, limonene was able to amplify the contraction induced by phenylephrine, while at higher concentrations, it inhibited it. The nitric oxide synthase blockers L-NAME and ruthenium red, a TRP ion channel blocker, did not significantly interfere with the biphasic character of limonene. However, indomethacin, a blocker of arachidonic acid derivatives, completely blocked the amplification of contraction induced by phenylephrine. In addition, limonene promoted relaxation in contractions induced by BAY-K 8644, a calcium channel agonist and by Ba²⁺. Limonene has complex effects on aortic tone, amplifying or inhibiting contractions, suggesting that the therapeutic window should be carefully studied to optimize clinical results.</div></div>","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111313"},"PeriodicalIF":4.7,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142649600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Special Issue: 21st International compendium: Enzymology and molecular biology of carbonyl metabolism","authors":"Natalia Y. Kedishvili (Managing Guest Editor)","doi":"10.1016/j.cbi.2024.111307","DOIUrl":"10.1016/j.cbi.2024.111307","url":null,"abstract":"","PeriodicalId":274,"journal":{"name":"Chemico-Biological Interactions","volume":"405 ","pages":"Article 111307"},"PeriodicalIF":4.7,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142634618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}