维生素 D 代谢途径相关基因多态性与心血管疾病之间的相关性。

IF 5.1 1区 农林科学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY Food & Function Pub Date : 2024-11-04 DOI:10.1039/d4fo03234a
Jiao Pang, Chunshuo Yang, Jiaqi Liu, Zhilin Wang, Xueshu Tao, Zhipeng Cao
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引用次数: 0

摘要

维生素 D 在各种生理过程中发挥着重要作用,如心血管健康、钙平衡调节、骨骼健康、免疫系统支持、神经功能调节、肌肉功能维持和抗炎作用。因此,保持足够的维生素水平对整体健康至关重要。维生素 D 代谢途径中的基因多态性已成为影响心血管疾病(CVD)易感性和进展的关键因素。本文回顾了维生素 D 代谢途径中的基因多态性与维生素 D 水平或心血管疾病之间的关系。文章强调,GC、VDR、CYP2R1、CYP24A1 和 CYP27B1 等关键基因的多态性与心血管疾病的发病机制有关。这些多态性可调节血清中维生素 D 的水平,从而影响心血管疾病的易感性、合并症和临床表现。尽管取得了进展,但文献中仍存在不一致和空白。因此,有必要开展大规模的多中心研究来验证这些发现,并加深我们对维生素 D 代谢途径中基因多态性与心血管疾病之间错综复杂的相互作用的理解。
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Correlation between vitamin D metabolic pathway-related gene polymorphisms and cardiovascular disease.

Vitamin D plays important roles in various physiological processes such as cardiovascular health, calcium balance regulation, bone health, immune system support, neurological function regulation, muscle function maintenance, and anti-inflammatory effects. Therefore, maintaining its adequate levels is essential for overall health. Genetic polymorphisms in vitamin D metabolic pathways have become a key factor affecting the susceptibility and progression of cardiovascular disease (CVD). This article reviews the relationship between gene polymorphisms in vitamin D metabolic pathways and vitamin D levels or CVD. It is emphasized that the polymorphisms of key genes such as GC, VDR, CYP2R1, CYP24A1 and CYP27B1 are related to the pathogenesis of CVD. These polymorphisms can regulate serum levels of vitamin D, thereby affecting the susceptibility, comorbidities and clinical manifestations of CVD. Despite the progress made, there are still inconsistencies and gaps in the literature. Thus, it is necessary to conduct large-scale, multicenter studies to verify these findings and deepen our understanding of the intricate interactions between gene polymorphisms in vitamin D metabolic pathways and CVD.

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来源期刊
Food & Function
Food & Function BIOCHEMISTRY & MOLECULAR BIOLOGY-FOOD SCIENCE & TECHNOLOGY
CiteScore
10.10
自引率
6.60%
发文量
957
审稿时长
1.8 months
期刊介绍: Food & Function provides a unique venue for physicists, chemists, biochemists, nutritionists and other food scientists to publish work at the interface of the chemistry, physics and biology of food. The journal focuses on food and the functions of food in relation to health.
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