金纳米团簇在反向乳液中的静电组装,实现结构和尺寸可调的纳米组装,增强近红外-II 荧光成像。

IF 15.8 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY ACS Nano Pub Date : 2024-11-04 DOI:10.1021/acsnano.4c10973
Yufeng Sun, Fei Qu, Rui Geng, Wanyue Xiao, Duohang Bi, Bijin Xiong, Yijing Liu, Jintao Zhu, Xiaoyuan Chen
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引用次数: 0

摘要

精确控制金纳米团簇(AuNCs)的组装结构和尺寸有可能放大其近红外 II(NIR-II)荧光成像和靶向特性。然而,AuNCs 和带电分子的传统静电组装在平衡带电单元之间固有的静电排斥和调节组装单元的扩散方面面临挑战。这些困难限制了对组装尺寸和结构的精确控制,以及对共组装分子的有限选择,从而限制了成像特性和靶向能力。为了规避这一挑战,我们开发了一种反向乳液封闭静电组装方法。这种技术能有效地构建具有不同共组装分子的 AuNC 纳米组装体,允许对组装体的大小和结构进行微调,包括核心卫星和同质 AuNC 纳米组装体。两种不同纳米组合体的形成可部分归因于 AuNC 或 AuNC/聚合物复合物在熔融乳液液滴中不同的扩散速率。这种差异源于乳液融合过程中遇到的立体阻碍。有趣的是,核-卫星纳米集合体表现出最强的近红外-II 荧光增强。最后,在不同尺寸的纳米组合体表面引入透明质酸涂层,可通过尺寸调节和巨噬细胞靶向增强淋巴结成像,用于手术导航以清除淋巴结转移灶。我们设想这种自组装策略可以扩展到多种静电组装系统,以开发多组分功能材料。
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Electrostatic Assembly of Gold Nanoclusters in Reverse Emulsion Enabling Nanoassemblies with Tunable Structure and Size for Enhanced NIR-II Fluorescence Imaging.

The precise control of the assembly structure and size of gold nanoclusters (AuNCs) can potentially amplify their near-infrared II (NIR-II) fluorescence imaging and targeting properties. However, the conventional electrostatic assembly of AuNCs and charged molecules faces challenges in balancing the inherent electrostatic repulsions among charged units and regulating the diffusion of assembly units. These difficulties limit precise control over assembly size and structure, along with limited options for coassembled molecules, thereby restricting imaging properties and targeting capability. To circumvent this challenge, we developed a reverse emulsion-confined electrostatic assembly method. This technique efficiently constructs AuNC nanoassemblies with diverse coassembled molecules, allowing for the fine-tuning of assembly size and structure, including both core-satellite and homogeneous AuNC nanoassemblies. The development of two distinct nanoassemblies can be partially attributed to the varying diffusive rates of AuNCs or the AuNCs/polymer complex within the fused emulsion droplets. This variance arises from steric hindrances encountered during the emulsion fusion process. Interestingly, core-satellite nanoassemblies exhibit the strongest NIR-II fluorescence enhancement. Finally, the introduction of a hyaluronic acid coating on the surfaces of nanoassemblies with varying sizes enables the nanoprobes to achieve enhanced lymph node imaging through size modulation and macrophage targeting, which are used for surgical navigation to remove lymph node metastases. We envision that this self-assembly strategy can be extended to a wide range of electrostatic assembly systems for the development of multicomponent functional materials.

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来源期刊
ACS Nano
ACS Nano 工程技术-材料科学:综合
CiteScore
26.00
自引率
4.10%
发文量
1627
审稿时长
1.7 months
期刊介绍: ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.
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