带有 X 射线可动超分子适配体构建单元的纳米放射增效剂,用于可编程免疫刺激 T 细胞参与。

IF 12.8 1区 医学 Q1 ENGINEERING, BIOMEDICAL Biomaterials Pub Date : 2024-10-29 DOI:10.1016/j.biomaterials.2024.122924
Jinming He , Xijiao Ren , Qiqi Zhang , Shuang Wang , Zhongjun Li , Kaiyong Cai , Menghuan Li , Yan Hu , Qian Ran , Zhong Luo
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引用次数: 0

摘要

在具有免疫抑制作用的肿瘤微环境(TME)中,T细胞活化不足且效应功能受损,这大大降低了放射治疗的免疫刺激效果。本文通过将分子设计的aptamer前体整合到顺铂负载脂质体中,建立了一种多功能纳米放射增敏剂,用于增强实体瘤的放射免疫治疗。在纳米放射增敏剂治疗后暴露于电离辐射(IR)中,会通过顺铂介导的放射增敏作用诱导肿瘤细胞明显的免疫原性死亡(ICD),同时也会引发aptamer前体的脱落、通过肿瘤源性 ATP 的桥接效应,这些前体进一步自组装成基于 PD-L1/PD-1 双特异性适配体的 T 细胞吞噬体(CA),以空间-时间可编程的方式引导 T 细胞结合到IR 后 TME 中的肿瘤细胞上。CA介导的后IR肿瘤细胞-T细胞结合可以克服TME中的免疫抑制障碍,增强T细胞介导的肿瘤细胞识别和清除,同时最大限度地减少全身毒性。总之,这项工作为提高放射免疫治疗的临床疗效提供了一种创新方法。
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Nanoradiosentizers with X ray-actuatable supramolecular aptamer building units for programmable immunostimulatory T cell engagement
The insufficient activation and impaired effector functions of T cells in the immunosuppressive tumor microenvironment (TME) substantially reduces the immunostimulatory effects of radiotherapy. Herein, a multifunctional nanoradiosensitizer is established by integrating molecularly engineered aptamer precursors into cisplatin-loaded liposomes for enhancing radio-immunotherapy of solid tumors. Exposure to ionizing radiation (IR) following the nanoradiosensitizer treatment would induce pronounced immunogenic death (ICD) of tumor cells through cisplatin-mediated radiosensitization while also trigger the detachment of the aptamer precursors, which further self-assemble into PD-L1/PD-1-bispecific aptamer-based T cell engagers (CA) through the bridging effect of tumor-derived ATP to direct T cell binding onto tumor cells in the post-IR TME in a spatial-temporally programmable manner. The CA-mediated post-IR tumor-T cell engagement could override the immunosuppressive barriers in TME and enhance T cell-mediated recognition and elimination of tumor cells while minimizing systemic toxicities. Overall, this work offers an innovative approach to enhance the radio-immunotherapeutic efficacy in the clinics.
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来源期刊
Biomaterials
Biomaterials 工程技术-材料科学:生物材料
CiteScore
26.00
自引率
2.90%
发文量
565
审稿时长
46 days
期刊介绍: Biomaterials is an international journal covering the science and clinical application of biomaterials. A biomaterial is now defined as a substance that has been engineered to take a form which, alone or as part of a complex system, is used to direct, by control of interactions with components of living systems, the course of any therapeutic or diagnostic procedure. It is the aim of the journal to provide a peer-reviewed forum for the publication of original papers and authoritative review and opinion papers dealing with the most important issues facing the use of biomaterials in clinical practice. The scope of the journal covers the wide range of physical, biological and chemical sciences that underpin the design of biomaterials and the clinical disciplines in which they are used. These sciences include polymer synthesis and characterization, drug and gene vector design, the biology of the host response, immunology and toxicology and self assembly at the nanoscale. Clinical applications include the therapies of medical technology and regenerative medicine in all clinical disciplines, and diagnostic systems that reply on innovative contrast and sensing agents. The journal is relevant to areas such as cancer diagnosis and therapy, implantable devices, drug delivery systems, gene vectors, bionanotechnology and tissue engineering.
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