基于磁性可回收催化剂：磺胺类药物的绿色战略。

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED Molecular Diversity Pub Date : 2024-11-04 DOI:10.1007/s11030-024-11030-4

Chuang Song, Mosstafa Kazemi

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引用次数: 0

摘要

磺胺类化合物是一类具有重要医药用途的化合物，随着磁性纳米催化剂的出现，磺胺类化合物的合成取得了显著进展。磁性纳米复合材料是最高效、应用最广泛的催化剂之一，从催化的角度来看，它们完全符合现代绿色化学的原则。这些催化剂通常由支撑在磁性纳米颗粒上的金属复合物组成，具有易于回收和可重复使用等独特优势，这对于可持续和生态友好型化学工艺至关重要。本综述全面探讨了应用磁性纳米催化剂制备磺酰胺的最新进展。重点领域包括各种磁性纳米催化剂（MNC）的设计与合成、它们在不同反应条件下的催化性能以及对其催化活性的机理认识。通过总结最新研究和技术进展，本文旨在为催化和药物化学领域的研究人员和从业人员提供有价值的资源。

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Based on magnetically recoverable catalysts: a green strategy to sulfonamides.

The synthesis of sulfonamides, a class of compounds with significant pharmaceutical and medicinal applications, has seen remarkable advancements with the advent of magnetic nanocatalysts. Magnetic nanocomposites are one of the most efficient and widely used catalysts, and they are in complete harmony with the principles of modern green chemistry from the point of view of catalysis. These catalysts, typically composed of metal complexes supported on magnetic nanoparticles, offer unique advantages such as ease of recovery and reusability, which are crucial for sustainable and eco-friendly chemical processes. This review comprehensively examines recent developments in applying magnetic nanocatalysts to prepare sulfonamides. Key focus areas include the design and synthesis of various magnetic nanocatalysts (MNC), their catalytic performance in different reaction conditions, and mechanistic insights into their catalytic activity. By summarizing the latest research and technological advancements, this article aims to provide a valuable resource for researchers and practitioners in catalysis and pharmaceutical chemistry.

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;