用聚丙烯酸对 ZIF-8 纳米粒子进行表面涂层:增强生物医学应用中化学稳定性的简便方法。

IF 4.4 4区 医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY Macromolecular bioscience Pub Date : 2024-11-03 DOI:10.1002/mabi.202400382
Setsuko Yamane, Abdul Hadi Bin Yusri, Po-Yu Chen, André J van der Vlies, Amira Ben Mabrouk, Isabelle Fetzer, Urara Hasegawa
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引用次数: 0

摘要

沸石咪唑框架-8(ZIF-8 NPs)纳米粒子是由锌离子和 2-甲基咪唑组成的金属有机框架的亚类,由于其大微孔结构适合封装疏水性药物分子,因此被认为是很有前途的药物载体。然而,ZIF-8 NPs 的局限性之一是其在生理溶液中的稳定性较低,尤其是在有水和磷酸盐阴离子存在的情况下。这些分子会与外表面配位不饱和的锌位点相互作用,导致 ZIF-8 NPs 降解。本研究采用一种简便的方法,通过表面涂覆聚丙烯酸(PAA)来增强 ZIF-8 NPs 的化学稳定性。PAA 涂层 ZIF-8 (PAA-ZIF-8) NPs 由 ZIF-8 NPs 和 PAA 在水中混合制备而成。PAA 涂层可抑制 ZIF-8 NPs 在水中和磷酸盐缓冲盐水中 6 天的降解,这似乎是由于 PAA 的羧基与反应性 Zn 位点配位所致。此外,负载抗癌药物多柔比星(Dox)的 PAA-ZIF-8 NPs 对人类结肠癌细胞具有细胞毒性。这些结果清楚地表明了 PAA 涂层方法在不影响 ZIF-8 NPs 药物输送能力的前提下提高其化学稳定性的可行性。
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Surface Coating of ZIF-8 Nanoparticles with Polyacrylic Acid: A Facile Approach to Enhance Chemical Stability for Biomedical Applications.

Nanoparticles of zeolitic imidazole framework-8 (ZIF-8 NPs), which are the subclass of metal-organic frameworks consisting of Zn ion and 2-methylimidazole, have been identified as promising drug carriers since their large microporous structure is suited for encapsulating hydrophobic drug molecules. However, one of the limitations of ZIF-8 NPs is their low stability in physiological solutions, especially in the presence of water and phosphate anions. These molecules can interact with the coordinatively unsaturated Zn sites at the external surface to induce the degradation of ZIF-8 NPs. In this study, herein a facile approach is reported to enhance the chemical stability of ZIF-8 NPs by surface coating with polyacrylic acid (PAA). The PAA-coated ZIF-8 (PAA-ZIF-8) NPs are prepared by mixing ZIF-8 NPs and PAA in water. PAA coating inhibits the degradation of ZIF-8 NPs in water as well as phosphate-buffered saline over 6 days, which seems to be due to the coordination of carboxyl groups of PAA to the reactive Zn sites. Furthermore, the PAA-ZIF-8 NPs loaded with the anticancer drug doxorubicin (Dox) show cytotoxicity in human colon cancer cells. These results clearly show the feasibility of the PAA coating approach to improve the chemical stability of ZIF-8 NPs without impairing their drug delivery capability.

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来源期刊
Macromolecular bioscience
Macromolecular bioscience 生物-材料科学:生物材料
CiteScore
7.90
自引率
2.20%
发文量
211
审稿时长
1.5 months
期刊介绍: Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.
期刊最新文献
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