社论：神经系统中的蛋白质翻译后修饰：从发育到疾病和衰老。

IF 3.5 3区医学 Q2 NEUROSCIENCES Frontiers in Molecular Neuroscience Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI:10.3389/fnmol.2024.1501719

Beatriz Alvarez, Judit Symmank, Geraldine Zimmer-Bensch, Miguel Diaz-Hernandez, Patricia Franzka

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引用次数: 0

摘要

蛋白质翻译后修饰（PTMs）对促进器官功能健康的生物过程至关重要。蛋白质翻译后修饰（PTMs），如磷酸化（P）、乙酰化（Ac）、SUMO 化（SUMO）、S-亚硝基化（Nitro）、泛素化（Ub）和糖基化（Glyco），影响着广泛的细胞和生物功能，如本漫画所示。干扰会严重影响大脑和肌肉等其他器官的正常功能。用 BioRender 制作。Hübner (2024) BioRender.com/j49w898。

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Editorial: Protein post-translational modifications in the nervous system: from development to disease and ageing.

PTMs are crucial for biological processes contributing to healthy organ function. Protein post-translational modifications (PTMs), such as phosphorylation (P), acetylation (Ac), SUMOylation (SUMO), S-nitrosylation (Nitro), ubiquitination (Ub) and glycosylation (Glyco), affect a wide range of cellular and biological functions as depicted in this cartoon. Perturbations lead to severe consequences for the normal function of the brain and other organs, such as muscle. Created in BioRender. Hübner (2024) BioRender.com/j49w898.

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来源期刊

Frontiers in Molecular Neuroscience NEUROSCIENCES-

CiteScore

5.70

自引率

2.10%

发文量

669

审稿时长

14 weeks

期刊介绍： Frontiers in Molecular Neuroscience is a first-tier electronic journal devoted to identifying key molecules, as well as their functions and interactions, that underlie the structure, design and function of the brain across all levels. The scope of our journal encompasses synaptic and cellular proteins, coding and non-coding RNA, and molecular mechanisms regulating cellular and dendritic RNA translation. In recent years, a plethora of new cellular and synaptic players have been identified from reduced systems, such as neuronal cultures, but the relevance of these molecules in terms of cellular and synaptic function and plasticity in the living brain and its circuits has not been validated. The effects of spine growth and density observed using gene products identified from in vitro work are frequently not reproduced in vivo. Our journal is particularly interested in studies on genetically engineered model organisms (C. elegans, Drosophila, mouse), in which alterations in key molecules underlying cellular and synaptic function and plasticity produce defined anatomical, physiological and behavioral changes. In the mouse, genetic alterations limited to particular neural circuits (olfactory bulb, motor cortex, cortical layers, hippocampal subfields, cerebellum), preferably regulated in time and on demand, are of special interest, as they sidestep potential compensatory developmental effects.