致编辑的信：经典HLA基因与无症状SARS-CoV-2感染之间缺乏关联。

IF 3.3 Q2 GENETICS & HEREDITY HGG Advances Pub Date : 2024-11-02 DOI:10.1016/j.xhgg.2024.100382

Eleanor Karp-Tatham, Callum R O'Neill, Julian C Knight, Alexander J Mentzer, Amanda Y Chong

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引用次数: 0

摘要

迄今为止，有关 HLA-B*15:01 与无症状 SARS-CoV-2 感染关系的研究结果相互矛盾。我们利用英国生物库队列发现，HLA-B*15:01 与无症状感染之间存在显著关联。我们的研究为 HLA 等位基因在 SARS-CoV-2 感染严重程度中所起的复杂作用提供了更多证据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Letter to the Editor: Lack of association between classical HLA genes and asymptomatic SARS-CoV-2 infection.

Research into HLA-B*15:01 association with asymptomatic SARS-CoV-2 infection has so far yielded contradicting results. Using the UK Biobank cohort, we found a significant association between HLA-B*15:01 and asymptomatic infection. Our study adds more evidence for the complex role HLA alleles play in SARS-Cov-2 infection severity.

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