优化人类免疫缺陷病毒感染者的心脏代谢风险:深入研究一个重要的风险增强因素

IF 4.3 Q1 CARDIAC & CARDIOVASCULAR SYSTEMS American journal of preventive cardiology Pub Date : 2024-10-28 DOI:10.1016/j.ajpc.2024.100888
Elizabeth A. Kobe , Aarti Thakkar , Sarina Matai , Esra Akkaya , Neha J. Pagidipati , Robert W. McGarrah , Gerald S. Bloomfield , Nishant P. Shah
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引用次数: 0

摘要

目前,有效的抗逆转录病毒疗法(ART)几乎无处不在。然而,抗逆转录病毒疗法带来的生存益处导致人类免疫缺陷病毒(HIV)人群老龄化和慢性疾病(如动脉粥样硬化性心血管疾病(ASCVD))风险增加。此外,HIV 是一种已知的 ASCVD 风险增强剂,现行的 2018 AHA/ACC 血液胆固醇指南也承认了这一点[1]。因此,在艾滋病病毒感染者(PLWH)中识别和改变心血管风险因素对预防心血管事件的重要性与日俱增。在这篇综述中,我们旨在总结 HIV 与动脉粥样硬化相关的流行病学和发病机制,并讨论针对 PLWH 的心血管代谢风险因素调整,包括肥胖、高血压、胰岛素抵抗、代谢功能障碍相关性脂肪肝和血脂异常。
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Optimizing cardiometabolic risk in people living with human immunodeficiency virus: A deep dive into an important risk enhancer
Effective antiretroviral therapy (ART) is now nearly ubiquitous. However, the survival benefits conferred with ART contribute to an aging human immunodeficiency virus (HIV) population and increased risk of chronic diseases, like atherosclerotic cardiovascular disease (ASCVD). Furthermore, HIV is a known risk enhancer of ASCVD and acknowledged as such in the current 2018 AHA/ACC Blood Cholesterol guidelines [1]. This makes cardiovascular risk factor identification and modification among people living with HIV (PLWH) of increasing importance to prevent cardiovascular events. In this review, we aim to summarize the epidemiology and pathogenesis of how HIV is linked to atherogenesis and to discuss cardiometabolic risk factor modification specific to PLWH, covering obesity, hypertension, insulin resistance, metabolic dysfunction-associated steatotic liver disease, and dyslipidemia.
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来源期刊
American journal of preventive cardiology
American journal of preventive cardiology Cardiology and Cardiovascular Medicine
CiteScore
6.60
自引率
0.00%
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0
审稿时长
76 days
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