星形胶质细胞有助于脑转移

IF 21.2 1区 医学 Q1 NEUROSCIENCES Nature neuroscience Pub Date : 2024-11-04 DOI:10.1038/s41593-024-01805-1
George Andrew S. Inglis
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引用次数: 0

摘要

转移到脑部的乳腺癌细胞往往是致命的,而有效的治疗方法却很少。在最近发表于《自然-细胞生物学》(Nature Cell Biology)的一项研究中,Yuzhalin 等人发现细胞周期蛋白依赖性激酶 CDK5 是治疗这些脑转移瘤的潜在靶点。与匹配的乳腺癌样本相比,在所有细胞周期蛋白依赖性激酶基因中,CDK5在人类脑转移瘤中的上调幅度最大。作者观察到,减少转移性乳腺癌细胞中 CDK5 的表达可提高免疫功能正常小鼠的存活率。此外,脑转移促进了星形胶质细胞中细胞外基质蛋白 emilin-1 的分泌。反过来,星形胶质细胞的 emilin-1 又会诱导脑转移灶中 CDK5 的表达,最终使这些癌细胞能够通过抑制 MHC-I 抗原递呈途径来逃避宿主的免疫反应。在这些结果的基础上,作者发现,CDK5抑制剂与免疫检查点抑制剂联合治疗小鼠可促进抗癌免疫反应并限制脑转移的严重程度。这些结果表明,星形胶质细胞 CDK5 可能支持脑转移的建立,并可能成为未来癌症治疗的靶点:Nat.原始参考文献:Nat.26, 1773-1789 (2024)
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来源期刊
Nature neuroscience
Nature neuroscience 医学-神经科学
CiteScore
38.60
自引率
1.20%
发文量
212
审稿时长
1 months
期刊介绍: Nature Neuroscience, a multidisciplinary journal, publishes papers of the utmost quality and significance across all realms of neuroscience. The editors welcome contributions spanning molecular, cellular, systems, and cognitive neuroscience, along with psychophysics, computational modeling, and nervous system disorders. While no area is off-limits, studies offering fundamental insights into nervous system function receive priority. The journal offers high visibility to both readers and authors, fostering interdisciplinary communication and accessibility to a broad audience. It maintains high standards of copy editing and production, rigorous peer review, rapid publication, and operates independently from academic societies and other vested interests. In addition to primary research, Nature Neuroscience features news and views, reviews, editorials, commentaries, perspectives, book reviews, and correspondence, aiming to serve as the voice of the global neuroscience community.
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