Stephanie L Smith, Lorna Paul, Martijn P M Steultjens, Rebecca L Jones
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A meta-analysis was undertaken based on the available data.</p><p><strong>Results: </strong>Twenty-four studies with 4101 participants with osteoarthritis were included (females: 78%; age range; 49 to 71 years). One study reported muscle-specific biomarkers (n = 3), whilst six studies reported osteoarthritis-specific markers (n = 5). Overall, 93 biomarkers were reported, predominately characterised as inflammatory (n = 35), metabolic (n = 15), and hormones (n = 10). Muscle strength and vitamin D reported a significant association (Hedge's g: 0.58 (Standard Error (SE): 0.27; P = 0.03), k = 3 studies). Walking speed and high-sensitivity C-reactive protein reported no significant associations (Hedge's g: -0.02 (SE: 0.05; P = 0.73), k = 3 studies).</p><p><strong>Conclusion: </strong>Associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis was limited, the few studies exploring lower limb muscle measures were mainly secondary outcomes. 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引用次数: 0
摘要
目的：骨骼肌功能障碍是骨关节炎患者功能受限的主要原因，相关的生物标志物有可能成为早期疾病识别、诊断和预防骨关节炎残疾的目标。本综述旨在确定骨关节炎患者的生物标志物与下肢骨骼肌功能之间的关联：从开始到 2023 年 8 月 8 日，在 PubMed、MEDLINE、CINAHL、EMBASE、Scopus、SPORTDiscus 和 Web of Science 数据库中进行了系统的文献综述和荟萃分析。两位独立审稿人对论文标题、摘要、全文进行了筛选，并对数据提取和方法学质量进行了评估。根据现有数据进行了荟萃分析：结果：共纳入 24 项研究，4101 名骨关节炎患者参与了研究（女性：78%；年龄范围：49 岁至 71 岁）。一项研究报告了肌肉特异性生物标记物（n = 3），六项研究报告了骨关节炎特异性标记物（n = 5）。总体而言，共报告了 93 种生物标记物，主要分为炎症标记物（35 种）、代谢标记物（15 种）和激素标记物（10 种）。据报告，肌肉力量与维生素 D 有显著关联（Hedge's g：0.58（标准误差 (SE)：0.27；P = 0.03），k = 3 项研究）。步行速度与高敏 C 反应蛋白无明显关联（Hedge's g：-0.02 (SE: 0.05; P = 0.73)，k = 3 项研究）：结论：骨关节炎患者的生物标志物与下肢骨骼肌功能之间的关联有限，少数几项探讨下肢肌肉指标的研究主要是次要结果。此外，生物标志物主要与整体健康有关，缺乏肌肉特异性生物标志物。因此，发生这些关联的机理途径并不明显，也很难就这些关系得出明确的结论：注册于 PROSPERO（CRD42022359405）。
Associations between biomarkers and skeletal muscle function in individuals with osteoarthritis: a systematic review and meta-analysis.
Objectives: Skeletal muscle dysfunction is the primary cause of functional limitations in osteoarthritis, associated biomarkers have the potential as targets for early disease identification, diagnosis, and prevention of osteoarthritis disability. This review aimed to identify associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis.
Methods: A systematic literature review and meta-analysis conducted in PubMed, MEDLINE, CINAHL, EMBASE, Scopus, SPORTDiscus and Web of Science databases from inception to 8th August 2023. Two independent reviewers performed the title, abstract, full-text screening, data extraction and methodological quality assessment. A meta-analysis was undertaken based on the available data.
Results: Twenty-four studies with 4101 participants with osteoarthritis were included (females: 78%; age range; 49 to 71 years). One study reported muscle-specific biomarkers (n = 3), whilst six studies reported osteoarthritis-specific markers (n = 5). Overall, 93 biomarkers were reported, predominately characterised as inflammatory (n = 35), metabolic (n = 15), and hormones (n = 10). Muscle strength and vitamin D reported a significant association (Hedge's g: 0.58 (Standard Error (SE): 0.27; P = 0.03), k = 3 studies). Walking speed and high-sensitivity C-reactive protein reported no significant associations (Hedge's g: -0.02 (SE: 0.05; P = 0.73), k = 3 studies).
Conclusion: Associations between biomarkers and lower limb skeletal muscle function in individuals with osteoarthritis was limited, the few studies exploring lower limb muscle measures were mainly secondary outcomes. Furthermore, biomarkers were largely related to overall health, with a lack of muscle specific biomarkers. As such, the mechanistic pathways through which these associations occur are less evident, and difficult to draw clear conclusions on these relationships.
Trial registration: Registered on PROSPERO (CRD42022359405).
期刊介绍：
Established in 1999, Arthritis Research and Therapy is an international, open access, peer-reviewed journal, publishing original articles in the area of musculoskeletal research and therapy as well as, reviews, commentaries and reports. A major focus of the journal is on the immunologic processes leading to inflammation, damage and repair as they relate to autoimmune rheumatic and musculoskeletal conditions, and which inform the translation of this knowledge into advances in clinical care. Original basic, translational and clinical research is considered for publication along with results of early and late phase therapeutic trials, especially as they pertain to the underpinning science that informs clinical observations in interventional studies.
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