腹部脂肪和骨骼肌分布异常对急诊大血管闭塞血管内治疗效果的影响。

IF 4.5 1区 医学 Q1 NEUROIMAGING Journal of NeuroInterventional Surgery Pub Date : 2024-11-13 DOI:10.1136/jnis-2024-022386
Chengcheng Cui, Zhiwen Geng, Hao Chen, Mengxia Lu, Yuqiao Wang, Dayong Shen, Rui Li, Lulu Xiao, Xinfeng Liu
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引用次数: 0

摘要

背景:本研究旨在探讨计算机断层扫描(CT)测量的肥胖成像指标与急诊血管内治疗(EVT)后90天和1年的临床结果之间的关系:方法:对接受急诊血管内治疗(EVT)的急诊大血管闭塞(ELVO)患者进行前瞻性登记。住院期间进行了CT扫描,以评估第三腰椎水平的内脏脂肪组织面积(VATA)和骨骼肌面积(SMA)。多变量回归分析用于评估肥胖相关成像指标与各种结果的相关性:死亡率、良好的功能结果(改良Rankin量表(mRS)评分0-2)以及90天和1年后的功能改善(mRS评分的变化):研究共纳入306名ELVO患者,中位年龄为64岁,美国国立卫生研究院卒中量表(NIHSS)中位数为18分。在调整了潜在的混杂因素后,VATA-to-SMA 比值(VSR)与 90 天后的良好功能预后(OR 0.30,95% CI 0.13 至 0.70)以及 1 年随访后的良好功能预后(OR 0.27,95% CI 0.12 至 0.61)和功能改善(OR 0.33,95% CI 0.12 至 0.92)显著相关:我们的研究表明,较低的 VSR 水平与良好的功能预后以及 90 天和 1 年随访时的功能改善相关。
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Effect of abnormal distribution of abdominal adiposity and skeletal muscle on the outcomes of endovascular treatment for emergent large vessel occlusion.

Background: The aim of this study was to investigate the relationships between imaging indicators of obesity, as measured by computed tomography (CT), and clinical outcomes at 90 days and 1 year after emergent endovascular therapy (EVT).

Methods: Participants with emergent large vessel occlusion (ELVO) who underwent EVT were prospectively enrolled. During hospitalization, CT scans were performed to evaluate the visceral adipose tissue area (VATA) and skeletal muscle area (SMA) at the level of the third lumbar spine. Multivariate regression analysis was used to assess the correlation of obesity-related imaging measures with various outcomes: mortality, favorable functional outcomes (modified Rankin scale (mRS) score 0-2), and functional improvement (shift in mRS score) at 90 days and 1 year.

Results: A total of 306 ELVO patients were included in the study, with a median age of 64 years and a median baseline National Institutes of Health Stroke Scale (NIHSS) score of 18. After adjusting for potential confounders, the VATA-to-SMA ratio (VSR) was significantly associated with a favorable functional outcome (OR 0.30, 95% CI 0.13 to 0.70) at 90 days and a favorable functional outcome (OR 0.27, 95% CI 0.12 to 0.61) and functional improvement (OR 0.33, 95% CI 0.12 to 0.92) at the 1 year follow-up.

Conclusion: Our study indicated that lower VSR levels are associated with favorable functional outcomes, along with functional improvement at 90 days and 1 year of follow-up.

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来源期刊
CiteScore
9.50
自引率
14.60%
发文量
291
审稿时长
4-8 weeks
期刊介绍: The Journal of NeuroInterventional Surgery (JNIS) is a leading peer review journal for scientific research and literature pertaining to the field of neurointerventional surgery. The journal launch follows growing professional interest in neurointerventional techniques for the treatment of a range of neurological and vascular problems including stroke, aneurysms, brain tumors, and spinal compression.The journal is owned by SNIS and is also the official journal of the Interventional Chapter of the Australian and New Zealand Society of Neuroradiology (ANZSNR), the Canadian Interventional Neuro Group, the Hong Kong Neurological Society (HKNS) and the Neuroradiological Society of Taiwan.
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