利用可见光通过芳基偶氮砜合成 1-芳基-3-磺酰基甲基-1,2,4-三唑

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED Advanced Synthesis & Catalysis Pub Date : 2024-11-04 DOI:10.1002/adsc.202401251

Luca Nicchio, Lorenzo Di Terlizzi, luc Neuville, Maurizio Fagnoni, Stefano Protti, Géraldine Masson

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引用次数: 0

摘要

我们介绍了一种合成多官能度 1,2,4-三唑的新型高效方法。这种方法利用可见光和芳基偶氮砜，结合 N-乙烯基酰胺，在环境友好型溶剂乙酸乙酯中进行。值得注意的是，反应进行时无需（光）催化剂，确保了近乎完美的原子经济性，并且只产生水作为副产品。这种方法对官能团的耐受性极佳，既可用于间歇工艺，也可用于连续流工艺。

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Visible-Light Enabled Synthesis of 1-Aryl-3-Sulfonylmethyl-1,2,4-Triazoles by Arylazo Sulfones

We present a novel and highly efficient method for synthesizing polyfunctionalized 1,2,4-triazoles. This approach leverages visible light and arylazo sulfones in combination with N-vinyl amides, in the environmentally friendly solvent ethyl acetate. Remarkably, the reaction proceeds without the need for (photo)catalysts, ensuring near-perfect atom economy and producing only water as a by-product. This method exhibits excellent functional group tolerance and can be scaled for both batch and continuous-flow processes.

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.