探索首发精神病患者运动灵活性的纵向发展过程:10 年随访。

IF 3.5 3区 医学 Q1 CLINICAL NEUROLOGY European Archives of Psychiatry and Clinical Neuroscience Pub Date : 2024-11-06 DOI:10.1007/s00406-024-01937-2
Manuel Sevilla-Ramos, Valentina Ladera, Ricardo García-García, Benedicto Crespo-Facorro, Rosa Ayesa-Arriola
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引用次数: 0

摘要

本研究旨在考察首次发作精神病(FEP)患者运动灵活性(MD)表现的纵向变化,重点关注特定诊断的轨迹。参与者来自西班牙的 PAFIP 项目(134 名 FEP,84 名 HC)。在基线和 10 年随访时,使用槽形钉板测试对 MD 进行评估。此外,还收集了患者的临床和病前数据。精神分裂症患者被分为精神分裂症(SCZ)和其他精神病(OP)两类,并与一组健康对照组(HC)进行了比较。所有参与者的 MD 均与年龄和智力明显相关。SCZ 患者的 MD 还与病前适应和阴性症状有关,而 OP 组的 MD 则与抗精神病药物剂量有关。SCZ患者的MD在随访中略有下降,而OP组和HC组则保持稳定。在 FEP 患者中,不同诊断的 MD 可能会有不同的长期轨迹。早期发育因素(如病前适应和认知功能)以及与年龄相关的变化可能会影响 MD 的轻度下降,特别是在精神分裂症患者中。
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Exploring the longitudinal course of motor dexterity in first-episode psychosis: a 10-year follow-up.

This study aimed to examine longitudinal changes in motor dexterity (MD) performance in first episode of psychosis (FEP), focusing on diagnosis-specific trajectories. Participants were recruited from the project PAFIP in Spain (134 FEP, 84 HC). MD was assessed using the Grooved Pegboard Test at baseline and at 10-year follow-up. Clinical and premorbid data were collected for the patients. FEP participants were classified as having schizophrenia (SCZ) or other psychosis (OP) and compared with a group of healthy controls (HC). MD correlated significantly with age and intelligence in all participants. MD in SCZ patients was additionally correlated with premorbid adjustment and negative symptoms, whereas in the OP group the association was with antipsychotic dose. SCZ patients showed a slight decline in MD at follow-up, whereas the OP and HC groups remained stable. There may be different long-term trajectories of MD across diagnoses in FEP patients. Early developmental factors such as premorbid adaptation and cognitive function, together with age-related changes, may influence a mild decline in MD specifically in schizophrenia.

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来源期刊
CiteScore
8.80
自引率
4.30%
发文量
154
审稿时长
6-12 weeks
期刊介绍: The original papers published in the European Archives of Psychiatry and Clinical Neuroscience deal with all aspects of psychiatry and related clinical neuroscience. Clinical psychiatry, psychopathology, epidemiology as well as brain imaging, neuropathological, neurophysiological, neurochemical and moleculargenetic studies of psychiatric disorders are among the topics covered. Thus both the clinician and the neuroscientist are provided with a handy source of information on important scientific developments.
期刊最新文献
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