代谢相关性脂肪肝和肝细胞癌。

IF 2.5 3区 医学 Q3 PHARMACOLOGY & PHARMACY Expert Opinion on Pharmacotherapy Pub Date : 2024-12-01 Epub Date: 2024-11-10 DOI:10.1080/14656566.2024.2426680
Giovanni Catalano, Odysseas P Chatzipanagiotou, Jun Kawashima, Timothy M Pawlik
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引用次数: 0

摘要

导言:代谢功能障碍相关性脂肪性肝病(MASLD)是描述在代谢失调背景下出现的脂肪性肝病的高级术语,随着代谢合并症发病率的增加,MASLD 将成为全球导致 HCC 的主要原因。因此,MASLD 已发展成为一个重要的公共卫生问题,有可能导致更高的肝脏死亡率和终末期肝病。为此,了解 MASLD 与 HCC 之间的关联可能有助于确定更好的干预措施和新型治疗策略:作者综述了目前关于MASLD患者发生HCC的知识,深入探讨了分子途径以及当前和未来的治疗策略:MASLD与HCC发病风险密切相关,因为代谢合并症会诱发分子通路失调,导致胰岛素抵抗、氧化应激和慢性炎症,从而引起肝硬化进展,最终导致HCC。以减少糖尿病相关并发症以及肥胖和吸烟率为重点的治疗策略可以改善患者的预后并降低 HCC 发病率。未来对代谢改变分子背景的研究可能有助于设计新的治疗方法,从而改善目前对 MASLD-HCC 的管理。
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Metabolic-associated steatotic liver disease and hepatocellular carcinoma.

Introduction: Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) has been introduced as a superior term to describe steatosis on a background of metabolic dysregulation and is slated to become the leading cause of HCC worldwide, as the incidence of metabolic comorbidities is increasing. As such, MASLD has evolved into an important public health issue, potentially leading to higher rates of liver mortality and end-stage liver disease. To this end, understanding the association between MASLD and HCC may allow for the identification of better interventions and novel therapeutic strategies.

Areas covered: The authors provide a review of current knowledge on HCC development among patients with MASLD, with insights into molecular pathways and current and future therapeutic strategies.

Expert opinion: MASLD has a strong association with the risk of HCC development, as metabolic comorbidities induce dysregulation in molecular pathways, leading to insulin-resistance, oxidative stress, and chronic inflammation, thus causing progression to cirrhosis and eventually to HCC. Therapeutic strategies focused on reducing diabetes-associated complications, as well as the prevalence of obesity and smoking can improve patient outcomes and reduce HCC incidence. Future studies on the molecular background of metabolic alterations may help devise new therapeutic approaches aiming to improve the current management of MASLD-HCC.

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来源期刊
CiteScore
5.60
自引率
3.10%
发文量
163
审稿时长
4-8 weeks
期刊介绍: Expert Opinion on Pharmacotherapy is a MEDLINE-indexed, peer-reviewed, international journal publishing review articles and original papers on newly approved/near to launch compounds mainly of chemical/synthetic origin, providing expert opinion on the likely impact of these new agents on existing pharmacotherapy of specific diseases.
期刊最新文献
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