胶质细胞中的 YAP 信号：神经发育、再生和疾病中的关键作用。

IF 5.9 2区医学 Q1 NEUROSCIENCES Neuroscience bulletin Pub Date : 2024-11-06 DOI:10.1007/s12264-024-01308-w

Lin Lin, Yinfeng Yuan, Zhihui Huang, Yongjie Wang

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引用次数: 0

摘要

YAP（Yes-associated protein）是Hippo通路的关键转录辅助因子和下游效应因子，已成为神经和神经胶质细胞的主要调节因子之一。它已在多种胶质细胞类型中被检测到，包括外周神经系统中的许旺细胞和嗅鞘细胞，以及中枢神经系统中的放射状胶质细胞、上皮细胞、伯格曼胶质细胞、视网膜 Müller 细胞、星形胶质细胞、少突胶质细胞和小胶质细胞。随着神经科学的发展，人们对 YAP 在神经胶质细胞生理或病理过程中功能的认识也在不断加深。在这篇综述中，我们旨在从一个综合的角度总结 YAP 在神经胶质细胞和神经胶质细胞相关疾病中的作用和潜在机制。

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YAP Signaling in Glia: Pivotal Roles in Neurological Development, Regeneration and Diseases.

Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in the peripheral nervous system, as well as radial glial cells, ependymal cells, Bergmann glia, retinal Müller cells, astrocytes, oligodendrocytes, and microglia in the central nervous system. With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.

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来源期刊

Neuroscience bulletin NEUROSCIENCES-

CiteScore

7.20

自引率

16.10%

发文量

163

审稿时长

6-12 weeks

期刊介绍： Neuroscience Bulletin (NB), the official journal of the Chinese Neuroscience Society, is published monthly by Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) and Springer. NB aims to publish research advances in the field of neuroscience and promote exchange of scientific ideas within the community. The journal publishes original papers on various topics in neuroscience and focuses on potential disease implications on the nervous system. NB welcomes research contributions on molecular, cellular, or developmental neuroscience using multidisciplinary approaches and functional strategies. We feature full-length original articles, reviews, methods, letters to the editor, insights, and research highlights. As the official journal of the Chinese Neuroscience Society, which currently has more than 12,000 members in China, NB is devoted to facilitating communications between Chinese neuroscientists and their international colleagues. The journal is recognized as the most influential publication in neuroscience research in China.