Lena Jelinek , Anna Serve , Saskia Pampuch , Jakob Scheunemann , Josephine Schultz , Franziska Miegel , Bjarne Hansen , Kristen Hagen , Frances Bohnsack , Jürgen Gallinat , Amir H. Yassari
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Exploring the Peaks and Potholes: Understanding positive and negative effects of concentrated exposure treatment for obsessive-compulsive disorder
The Bergen 4-Day Treatment offers brief concentrated exposure with response prevention (cERP) for obsessive-compulsive disorder (OCD). To date, this intervention has primarily been studied in Norway, and no study has been done on its side effects. We tested the safety, feasibility, and effectiveness of cERP in Germany and compared cERP to a historical inpatient control group.
Thirty-three patients with OCD were treated with cERP. We assessed severity of OCD (primary outcome: Y-BOCS), depression, global functioning, self-esteem, self-efficacy, experiential avoidance, and quality of life at baseline (t0), two weeks after t0 (t1), and three months after t1 (t2). Side effects were assessed at t1 and t2. The changes in OCD were compared to a matched historical inpatient control group (n = 33) treated at the same site.
The cERP group improved over time, with a large effect size in OCD symptoms and other outcome measures. Improvement of OCD symptoms over treatment was superior in the cERP group compared to the historical control group, with a medium effect size for OCD symptoms. 53–56% of the participants reported at least one side effect (e.g., exhaustion). cERP is safe and effective in the treatment of OCD and can be successfully implemented in Germany.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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