Tao He, Peng Wang, Li-Xia Wang, Meng-Han Tong, Zhi-Jun Duan
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Among these participants, a total of 9,947 individuals were classified into four groups based on their obesity phenotype: metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO). To account for potential confounding factors, multivariate logistic regression analysis was applied to examine the association between metabolic obesity phenotypes and the risk of RE, with stratification by sex and age.</p><p><strong>Results: </strong>Among all participants, the MUNW, MHO, and MUO groups demonstrated a higher risk of RE when compared to the MHNW group. After controlling for all confounding factors, the MUO group exhibited the highest risk, with an odds ratio (OR) of 3.723 (95% CI: 2.751-5.040) in males and 5.482 (95% CI: 4.080-7.367) in females. The prevalence of RE increased in proportion to the number of metabolic risk factors. Subgroup analyses, which accounted for all confounders, revealed that the MHO, MUNW, and MUO phenotypes were associated with an elevated risk of RE in individuals under 60 years old as well as those over 60 years old. Interestingly, a more comprehensive analysis indicated that obesity may have a greater effect on the risk of RE than metabolic disorders.</p><p><strong>Conclusions: </strong>Both metabolic disorders and obesity were associated with an increased risk of RE. The effect of obesity on RE prevalence may be stronger than that of metabolic disorders, emphasizing the significance of obesity regardless of metabolic health status. Clinical interventions should address not only obesity but also metabolic disorders in order to reduce the risk of RE.</p>","PeriodicalId":9152,"journal":{"name":"BMC Endocrine Disorders","volume":"24 1","pages":"239"},"PeriodicalIF":2.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11542364/pdf/","citationCount":"0","resultStr":"{\"title\":\"Relationship of different metabolic obesity phenotypes with reflux esophagitis: a propensity score matching analysis.\",\"authors\":\"Tao He, Peng Wang, Li-Xia Wang, Meng-Han Tong, Zhi-Jun Duan\",\"doi\":\"10.1186/s12902-024-01771-6\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Obesity is associated with an increased risk of reflux esophagitis (RE). Metabolic abnormalities have been implicated in the pathogenesis of RE. However, the role of metabolic status in the risk of RE among individuals with varying degrees of obesity remains unclear. Therefore, our study aimed to assess the association between metabolic obesity phenotypes and the risk of RE.</p><p><strong>Methods: </strong>This study included a cohort of 24,368 participants aged 18 years and older who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital of Dalian Medical University during health checkups between January 1, 2008, and December 31, 2021. Among these participants, a total of 9,947 individuals were classified into four groups based on their obesity phenotype: metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO). To account for potential confounding factors, multivariate logistic regression analysis was applied to examine the association between metabolic obesity phenotypes and the risk of RE, with stratification by sex and age.</p><p><strong>Results: </strong>Among all participants, the MUNW, MHO, and MUO groups demonstrated a higher risk of RE when compared to the MHNW group. After controlling for all confounding factors, the MUO group exhibited the highest risk, with an odds ratio (OR) of 3.723 (95% CI: 2.751-5.040) in males and 5.482 (95% CI: 4.080-7.367) in females. The prevalence of RE increased in proportion to the number of metabolic risk factors. Subgroup analyses, which accounted for all confounders, revealed that the MHO, MUNW, and MUO phenotypes were associated with an elevated risk of RE in individuals under 60 years old as well as those over 60 years old. Interestingly, a more comprehensive analysis indicated that obesity may have a greater effect on the risk of RE than metabolic disorders.</p><p><strong>Conclusions: </strong>Both metabolic disorders and obesity were associated with an increased risk of RE. The effect of obesity on RE prevalence may be stronger than that of metabolic disorders, emphasizing the significance of obesity regardless of metabolic health status. 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引用次数: 0
摘要
背景:肥胖与反流性食管炎(RE)风险增加有关。代谢异常与反流性食管炎的发病机制有关。然而,新陈代谢状况在不同肥胖程度的人中发生反流性食管炎的风险中所起的作用仍不清楚。因此,我们的研究旨在评估代谢性肥胖表型与RE风险之间的关联:本研究纳入了2008年1月1日至2021年12月31日期间在大连医科大学附属第一医院健康体检期间接受上消化道内镜检查的24368名18岁及以上参与者。根据肥胖表型将其中的9947人分为四组:代谢健康正常体重组(MHNW)、代谢健康肥胖组(MHO)、代谢不健康正常体重组(MUNW)和代谢不健康肥胖组(MUO)。为了考虑潜在的混杂因素,研究人员采用了多变量逻辑回归分析来研究代谢性肥胖表型与RE风险之间的关系,并按性别和年龄进行了分层:在所有参与者中,MUNW、MHO和MUO组的RE风险高于MHNW组。在控制了所有干扰因素后,MUO 组的风险最高,男性的几率比(OR)为 3.723(95% CI:2.751-5.040),女性的几率比(OR)为 5.482(95% CI:4.080-7.367)。RE发病率的增加与代谢风险因素的数量成正比。考虑了所有混杂因素的分组分析显示,MHO、MUNW 和 MUO 表型与 60 岁以下和 60 岁以上人群的 RE 风险升高有关。有趣的是,一项更全面的分析表明,肥胖对RE风险的影响可能大于代谢紊乱:结论:代谢紊乱和肥胖都与RE风险增加有关。肥胖对 RE 患病率的影响可能比代谢紊乱的影响更大,这强调了肥胖的重要性,无论代谢健康状况如何。临床干预措施不仅应针对肥胖,还应针对代谢紊乱,以降低RE的风险。
Relationship of different metabolic obesity phenotypes with reflux esophagitis: a propensity score matching analysis.
Background: Obesity is associated with an increased risk of reflux esophagitis (RE). Metabolic abnormalities have been implicated in the pathogenesis of RE. However, the role of metabolic status in the risk of RE among individuals with varying degrees of obesity remains unclear. Therefore, our study aimed to assess the association between metabolic obesity phenotypes and the risk of RE.
Methods: This study included a cohort of 24,368 participants aged 18 years and older who underwent upper gastrointestinal endoscopy at the First Affiliated Hospital of Dalian Medical University during health checkups between January 1, 2008, and December 31, 2021. Among these participants, a total of 9,947 individuals were classified into four groups based on their obesity phenotype: metabolically healthy normal weight (MHNW), metabolically healthy obesity (MHO), metabolically unhealthy normal weight (MUNW), and metabolically unhealthy obesity (MUO). To account for potential confounding factors, multivariate logistic regression analysis was applied to examine the association between metabolic obesity phenotypes and the risk of RE, with stratification by sex and age.
Results: Among all participants, the MUNW, MHO, and MUO groups demonstrated a higher risk of RE when compared to the MHNW group. After controlling for all confounding factors, the MUO group exhibited the highest risk, with an odds ratio (OR) of 3.723 (95% CI: 2.751-5.040) in males and 5.482 (95% CI: 4.080-7.367) in females. The prevalence of RE increased in proportion to the number of metabolic risk factors. Subgroup analyses, which accounted for all confounders, revealed that the MHO, MUNW, and MUO phenotypes were associated with an elevated risk of RE in individuals under 60 years old as well as those over 60 years old. Interestingly, a more comprehensive analysis indicated that obesity may have a greater effect on the risk of RE than metabolic disorders.
Conclusions: Both metabolic disorders and obesity were associated with an increased risk of RE. The effect of obesity on RE prevalence may be stronger than that of metabolic disorders, emphasizing the significance of obesity regardless of metabolic health status. Clinical interventions should address not only obesity but also metabolic disorders in order to reduce the risk of RE.
期刊介绍:
BMC Endocrine Disorders is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of endocrine disorders, as well as related molecular genetics, pathophysiology, and epidemiology.