面部老化、认知障碍和痴呆症风险。

IF 7.9 1区 医学 Q1 CLINICAL NEUROLOGY Alzheimer's Research & Therapy Pub Date : 2024-11-06 DOI:10.1186/s13195-024-01611-8
Xinming Xu, Guliyeerke Jigeer, David Andrew Gunn, Yizhou Liu, Xinrui Chen, Yi Guo, Yaqi Li, Xuelan Gu, Yanyun Ma, Jiucun Wang, Sijia Wang, Liang Sun, Xu Lin, Xiang Gao
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引用次数: 0

摘要

背景:面部衰老、认知障碍和痴呆症都是与年龄相关的疾病。然而,面部年龄与未来痴呆症风险之间的时间关系尚未得到系统研究:调查面部年龄(主观/感知和客观)与认知障碍和/或痴呆风险之间的关系:研究纳入了英国生物库(UKB)中195329名自我感知面部年龄的参与者(年龄≥60岁)和中国老龄人口营养与健康项目(NHAPC)研究中612名客观评估面部年龄的参与者(年龄≥56岁)。在调整年龄、性别、教育程度、APOE ε4等位基因和其他潜在混杂因素的基础上,采用Cox比例危险模型前瞻性地研究了英国老年痴呆症患者自我感觉面部年龄与痴呆风险的危险比(HRs)及其95%置信区间(CIs)。在对潜在的混杂因素进行调整后,进行线性回归和逻辑回归,以检验英国脑电图和国家人类心理健康调查中面部年龄(感知年龄和客观年龄)与认知障碍之间的横断面关联:结果:在中位数为 12.3 年的随访期间,英国调查局共发现了 5659 例痴呆症病例。经完全调整后,面部年龄高与面部年龄低的痴呆症HR值为1.61(95% CI,1.33 ~ 1.96)(P趋势≤ 0.001)。主观面部年龄与认知障碍的关系在英国广播公司中也有观察到。在 NHAPC 中,通过三个客观皱纹参数评估的面部年龄与认知障碍的几率较高相关(P-趋势 结论:面部年龄高与认知障碍相关:在对痴呆症的常规风险因素进行调整后,高面部年龄与认知障碍、痴呆症及其亚型相关。面部老化可能是老年人认知能力下降和痴呆症风险的一个指标,有助于早期诊断和管理与年龄有关的疾病。
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Facial aging, cognitive impairment, and dementia risk.

Background: Facial aging, cognitive impairment, and dementia are all age-related conditions. However, the temporal relation between facial age and future risk of dementia was not systematically examined.

Objectives: To investigate the relationship between facial age (both subjective/perceived and objective) and cognitive impairment and/or dementia risk.

Methods: The study included 195,329 participants (age ≥ 60 y) from the UK Biobank (UKB) with self-perceived facial age and 612 participants from the Nutrition and Health of Aging Population in China Project (NHAPC) study (age ≥ 56 y) with objective assessment of facial age. Cox proportional hazards model was used to prospectively examine the hazard ratios (HRs) and their 95% confidence intervals (CIs) of self-perceived facial age and dementia risk in the UKB, adjusting for age, sex, education, APOE ε4 allele, and other potential confounders. Linear and logistic regressions were performed to examine the cross-sectional association between facial age (perceived and objective) and cognitive impairment in the UKB and NHAPC, with potential confounders adjusted.

Results: During a median follow-up of 12.3 years, 5659 dementia cases were identified in the UKB. The fully-adjusted HRs comparing high vs. low perceived facial age were 1.61 (95% CI, 1.33 ~ 1.96) for dementia (P-trend ≤ 0.001). Subjective facial age and cognitive impairment was also observed in the UKB. In the NHAPC, facial age, as assessed by three objective wrinkle parameters, was associated with higher odds of cognitive impairment (P-trend < 0.05). Specifically, the fully-adjusted OR for cognitive impairment comparing the highest versus the lowest quartiles of crow's feet wrinkles number was 2.48 (95% CI, 1.06 ~ 5.78).

Conclusions: High facial age was associated with cognitive impairment, dementia and its subtypes after adjusting for conventional risk factors for dementia. Facial aging may be an indicator of cognitive decline and dementia risk in older adults, which can aid in the early diagnosis and management of age-related conditions.

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来源期刊
Alzheimer's Research & Therapy
Alzheimer's Research & Therapy 医学-神经病学
CiteScore
13.10
自引率
3.30%
发文量
172
审稿时长
>12 weeks
期刊介绍: Alzheimer's Research & Therapy is an international peer-reviewed journal that focuses on translational research into Alzheimer's disease and other neurodegenerative diseases. It publishes open-access basic research, clinical trials, drug discovery and development studies, and epidemiologic studies. The journal also includes reviews, viewpoints, commentaries, debates, and reports. All articles published in Alzheimer's Research & Therapy are included in several reputable databases such as CAS, Current contents, DOAJ, Embase, Journal Citation Reports/Science Edition, MEDLINE, PubMed, PubMed Central, Science Citation Index Expanded (Web of Science) and Scopus.
期刊最新文献
Facial aging, cognitive impairment, and dementia risk. Exploring easily accessible neurophysiological biomarkers for predicting Alzheimer's disease progression: a systematic review. Sex-specific risk factors and clinical dementia outcomes for white matter hyperintensities in a large South Korean cohort. Perivascular space enlargement accelerates in ageing and Alzheimer's disease pathology: evidence from a three-year longitudinal multicentre study. Assessing the metabolism of the olfactory circuit by use of 18F-FDG PET-CT imaging in patients suspected of suffering from Alzheimer's disease or frontotemporal dementia.
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