{"title":"答复\"重新评估虚弱与慢性肝病之间的因果关系:来自基因分析的证据\"","authors":"Qi Zhong, Hao-Wen Chen, Shun Zhang, Ji-Yuan Zhou, Xian-Bo Wu","doi":"10.1016/j.jhep.2024.10.034","DOIUrl":null,"url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Data availability statement</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section><section><section><h2>Authors’ contributions</h2>QZ, H-WC, and SZ drafted the manuscript and performed the main MR analyses. X-BW and J-YZ revised the manuscript. All authors reviewed and approved the final manuscript.</section></section><section><section><h2>Financial support</h2>This study was supported by the National Natural Science Foundation of China [grant numbers 82173607, 82173619], and the Guangdong Basic and Applied Basic Research Foundation [grant numbers 2021A1515011684, 2024A1515011969]. The funders had no role in study design, data collection or analysis, data interpretation, manuscript writing, or decision to submit the paper for publication.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors of this study declare that they do not have any conflict of interest.</section></section><section><section><h2>Acknowledgements</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"61 1","pages":""},"PeriodicalIF":26.8000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Reply to: “Reassessing the causal association between frailty and chronic liver disease: Evidence from genetic analyses”\",\"authors\":\"Qi Zhong, Hao-Wen Chen, Shun Zhang, Ji-Yuan Zhou, Xian-Bo Wu\",\"doi\":\"10.1016/j.jhep.2024.10.034\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h2>Section snippets</h2><section><section><h2>Data availability statement</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\\\"Opens in new window\\\" focusable=\\\"false\\\" height=\\\"20\\\" viewbox=\\\"0 0 8 8\\\"><path d=\\\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\\\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\\\"Opens in new window\\\" focusable=\\\"false\\\" height=\\\"20\\\" viewbox=\\\"0 0 8 8\\\"><path d=\\\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\\\"></path></svg></span>).</section></section><section><section><h2>Authors’ contributions</h2>QZ, H-WC, and SZ drafted the manuscript and performed the main MR analyses. X-BW and J-YZ revised the manuscript. All authors reviewed and approved the final manuscript.</section></section><section><section><h2>Financial support</h2>This study was supported by the National Natural Science Foundation of China [grant numbers 82173607, 82173619], and the Guangdong Basic and Applied Basic Research Foundation [grant numbers 2021A1515011684, 2024A1515011969]. The funders had no role in study design, data collection or analysis, data interpretation, manuscript writing, or decision to submit the paper for publication.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors of this study declare that they do not have any conflict of interest.</section></section><section><section><h2>Acknowledgements</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\\\"Opens in new window\\\" focusable=\\\"false\\\" height=\\\"20\\\" viewbox=\\\"0 0 8 8\\\"><path d=\\\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\\\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\\\"Opens in new window\\\" focusable=\\\"false\\\" height=\\\"20\\\" viewbox=\\\"0 0 8 8\\\"><path d=\\\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\\\"></path></svg></span>).</section></section>\",\"PeriodicalId\":15888,\"journal\":{\"name\":\"Journal of Hepatology\",\"volume\":\"61 1\",\"pages\":\"\"},\"PeriodicalIF\":26.8000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhep.2024.10.034\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhep.2024.10.034","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Reply to: “Reassessing the causal association between frailty and chronic liver disease: Evidence from genetic analyses”
Section snippets
Data availability statement
GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (https://gwas.mrcieu.ac.uk/). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (https://r11.finngen.fi/).
Authors’ contributions
QZ, H-WC, and SZ drafted the manuscript and performed the main MR analyses. X-BW and J-YZ revised the manuscript. All authors reviewed and approved the final manuscript.
Financial support
This study was supported by the National Natural Science Foundation of China [grant numbers 82173607, 82173619], and the Guangdong Basic and Applied Basic Research Foundation [grant numbers 2021A1515011684, 2024A1515011969]. The funders had no role in study design, data collection or analysis, data interpretation, manuscript writing, or decision to submit the paper for publication.
Declaration of Competing Interest
The authors of this study declare that they do not have any conflict of interest.
Acknowledgements
GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (https://gwas.mrcieu.ac.uk/). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (https://r11.finngen.fi/).
期刊介绍:
The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.