Journal of Hepatology最新文献

{"title":"Reply to: “Reassessing the causal association between frailty and chronic liver disease: Evidence from genetic analyses”","authors":"Qi Zhong, Hao-Wen Chen, Shun Zhang, Ji-Yuan Zhou, Xian-Bo Wu","doi":"10.1016/j.jhep.2024.10.034","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.034","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Data availability statement</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section><section><section><h2>Authors’ contributions</h2>QZ, H-WC, and SZ drafted the manuscript and performed the main MR analyses. X-BW and J-YZ revised the manuscript. All authors reviewed and approved the final manuscript.</section></section><section><section><h2>Financial support</h2>This study was supported by the National Natural Science Foundation of China [grant numbers 82173607, 82173619], and the Guangdong Basic and Applied Basic Research Foundation [grant numbers 2021A1515011684, 2024A1515011969]. The funders had no role in study design, data collection or analysis, data interpretation, manuscript writing, or decision to submit the paper for publication.</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors of this study declare that they do not have any conflict of interest.</section></section><section><section><h2>Acknowledgements</h2>GWAS summary statistics for frailty are available for download from the MRC-IEU GWAS database (<span><span>https://gwas.mrcieu.ac.uk/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>). Similarly, GWAS summary statistics for liver disease can be accessed through the FinnGen consortium (<span><span>https://r11.finngen.fi/</span><svg aria-label=\"Opens in new window\" focusable=\"false\" height=\"20\" viewbox=\"0 0 8 8\"><path d=\"M1.12949 2.1072V1H7V6.85795H5.89111V2.90281L0.784057 8L0 7.21635L5.11902 2.1072H1.12949Z\"></path></svg></span>).</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to: “From mice to humans: Unravelling the genetic levers of NASH” [J Hepatol (2020) 749-751]","authors":"Wajahat Zafar Mehal","doi":"10.1016/j.jhep.2024.10.002","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.002","url":null,"abstract":"It has come to our attention that the following text should have been included in the ‘Financial support’ section of this article: “Dr. Mehal has an appointment at the West Haven VA Medical Center and this work was supported by a US Department of Veterans Office of Research &amp; Development with grant BX003259-05A1”. We apologise for any inconvenience caused.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rethinking Methodology and Data Integrity in Mendelian Randomization: Insights from Air Pollution and MASLD Research","authors":"Junhao Chen, Haifeng Wang, Shi Fu","doi":"10.1016/j.jhep.2024.10.040","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.040","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Authors’ contributions</h2>Junhao Chen: conceptualization and manuscript draft. Haifeng Wang: supporting role in revision for important intellectual content. Shi Fu: critical revision for important intellectual content, final approval.</section></section><section><section><h2>Financial support</h2>None</section></section><section><section><h2>Declaration of Competing Interest</h2>The authors of this study declare that they do not have any conflict of interest.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Prediction of HBsAg loss after cessation of entecavir therapy”","authors":"Rex Wan-Hin Hui, Lung-Yi Mak, Man-Fung Yuen","doi":"10.1016/j.jhep.2024.10.041","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.041","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>AUTHOR CONTRIBUTIONS</h2>RWH Hui was involved in manuscript design and drafting of manuscript. LY Mak was involved in critical revision of manuscript. MF Yuen was involved in critical revision of manuscript and overall study supervision. The authors declare that they have participated in the preparation of the manuscript and have seen and approved the final version.</section></section><section><section><h2>DISCLOSURES/ CONFLICT OF INTEREST STATEMENT</h2>MF Yuen is an advisory board member and/or received research funding from AbbVie, Arbutus Biopharma, Assembly Biosciences, Bristol Myer Squibb, Dicerna Pharmaceuticals, GlaxoSmithKline, Gilead Sciences, Janssen, Merck Sharp and Dohme, Clear B Therapeutics, Springbank Pharmaceuticals; and received research funding from Arrowhead Pharmaceuticals, Fujirebio Incorporation and Sysmex Corporation. The remaining authors have no conflict of interests.</section></section><section><section><h2>DATA AVAILABILITY STATEMENT</h2>The data from this study is available from the corresponding author upon reasonable request.</section></section><section><section><h2>Funding</h2>Innovative Research Fund of the State Key Laboratory of Liver Research, The University of Hong Kong (ref. no.: SKLLR/IRF/2018/07) and the S. K. Yee Medical Foundation Grant (ref. no.: 2141213). The funders had no involvement in study design, data collection/ analysis/ interpretation, writing of the manuscript or decision to submit the article for publication.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to make a decision for the use of plasma exchange in patients with acute liver failure?","authors":"Xiang-Yu Han, Hui-ru Qi","doi":"10.1016/j.jhep.2024.10.038","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.038","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial support</h2>The author received no financial support to produce this manuscript.</section></section><section><section><h2>Authors’ contributions</h2>Xiang-Yu Han: manuscript writing; Hui-ru Qi: critical revision</section></section><section><section><h2>Declaration of Competing Interest</h2>The author declare no conflicts of interest.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Plasma exchange in Acute liver failure: The jury is still out!","authors":"Sagnik Biswas, Shekhar Swaroop","doi":"10.1016/j.jhep.2024.10.037","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.037","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial disclosures funding</h2>None</section></section><section><section><h2>Conflicts of interest COI</h2>The authors declare no conflicts of interest</section></section><section><section><h2>Authors contributions author-disclosure</h2>SB and SS wrote the initial draft. S revised the paper. All authors approved the final manuscript.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142594290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: “Community health strategies for chronic hepatitis B: Advancing care with the ALT/qHBsAg ratio”","authors":"Rex Wan-Hin Hui, Lung-Yi Mak, Man-Fung Yuen","doi":"10.1016/j.jhep.2024.10.042","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.042","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Author Contributions</h2>RWH Hui was involved in manuscript design and drafting of manuscript. LY Mak was involved in critical revision of manuscript. MF Yuen was involved in critical revision of manuscript and overall study supervision. The authors declare that they have participated in the preparation of the manuscript and have seen and approved the final version.</section></section><section><section><h2>Disclosures/ Conflict Of Interest Statement</h2>MF Yuen is an advisory board member and/or received research funding from AbbVie, Arbutus Biopharma, Assembly Biosciences, Bristol Myer Squibb, Dicerna Pharmaceuticals, GlaxoSmithKline, Gilead Sciences, Janssen, Merck Sharp and Dohme, Clear B Therapeutics, Springbank Pharmaceuticals; and received research funding from Arrowhead Pharmaceuticals, Fujirebio Incorporation and Sysmex Corporation. The remaining authors have no conflict of interests.</section></section><section><section><h2>Data Availability Statement</h2>The data from this study is available from the corresponding author upon reasonable request.</section></section><section><section><h2>Funding</h2>Innovative Research Fund of the State Key Laboratory of Liver Research, The University of Hong Kong (ref. no.: SKLLR/IRF/2018/07) and the S. K. Yee Medical Foundation Grant (ref. no.: 2141213). The funders had no involvement in study design, data collection/ analysis/ interpretation, writing of the manuscript or decision to submit the article for publication.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam: Prof. Francesco Salerno","authors":"Vincenzo La Mura, Mauro Bernardi, Paolo Angeli","doi":"10.1016/j.jhep.2024.09.036","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.09.036","url":null,"abstract":"Professor Francesco Salerno was a brilliant man who dedicated his life to helping patients with advanced chronic liver diseases and who was internationally renowned for his studies on the pathophysiology of cirrhosis and its complications, as well as the management of patients with ascites, renal dysfunction and bacterial infections. He contributed to the foundation of key international groups such as the International Club of Ascites, the CLIF consortium, and the Baveno group.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Late use of Plasma Exchange in Acute Liver Failure: The Battle is Lost?","authors":"Valentin Coirier, Florent Artru, Christophe Camus","doi":"10.1016/j.jhep.2024.10.039","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.039","url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Declaration of Competing Interest</h2>none</section></section><section><section><h2>Financial disclosure</h2>none</section></section><section><section><h2>Author contributions</h2>all authors contributed equally to the manuscript in terms of concept, writing, editing.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142588327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is there a safe limit for consumption of alcohol?","authors":"Jessica Ann Musto, Randall Brown, Michael Ronan Lucey","doi":"10.1016/j.jhep.2024.10.024","DOIUrl":"https://doi.org/10.1016/j.jhep.2024.10.024","url":null,"abstract":"In order to understand and curb the harms related to alcohol, it will be necessary to think beyond patterns of use that meet criteria for a diagnosis of alcohol use disorder, or addiction. Current research suggests that regular daily alcohol use does not confer a health benefit, and for many persons, even relatively low consumption is associated with a health risk. Determining a safe limit for alcohol consumption is challenging both for the individual person and for society. We conclude that excessive drinking is always risky. We provide a list of circumstances, such as chronic illness, driving a vehicle, or pregnancy where persons should be advised to abstain from alcohol. We recognize the need to encourage less consumption of alcohol, particularly in young adults, and in older adults with co-morbid conditions particularly when taking multiple medications. Finally, we offer the modest proposal that, for persons without the contributing negative influences described above, consumption which adheres to one drink per session, with interspersed abstinent days, does not constitute a meaningful risk to health.","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":null,"pages":null},"PeriodicalIF":25.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142562215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}