全氟和多氟烷基物质(PFAS):用于人类生物监测的质谱分析趋势以及近期全球队列研究得出的暴露模式

IF 10.3 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environment International Pub Date : 2024-11-07 DOI:10.1016/j.envint.2024.109117
Kyung Hwa Kee, Jeong In Seo, Su Min Kim, Jentaie Shiea, Hye Hyun Yoo
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引用次数: 0

摘要

全氟烷基和多氟烷基物质(PFAS)是一种广泛存在的环境污染物,已被证明会导致人类接触这种物质,从而引发一系列健康问题。在这种情况下,人体生物监测对于将 PFAS 暴露水平与其潜在健康风险联系起来至关重要。基于质谱法的分析技术已被广泛用于评估各类人群的 PFAS 水平。然而,由于生物样本(如血浆、血清、尿液等)的使用所带来的挑战,有必要对分析方法进行持续研究和改进。本综述概述了目前基于质谱的 PFAS 人体生物监测方法的发展趋势,包括样品的采集和制备以及仪器技术。我们还探讨了克服在获取不含 PFAS 的空白基质和应对背景污染风险方面的挑战的分析策略。此外,本综述还通过分析最近的国际队列研究,特别是过去五年在美国和中国进行的研究,探讨了不同地区的 PFAS 暴露模式。因此,本综述强调了生物监测研究中需要解决的几个关键研究缺口。
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Per- and polyfluoroalkyl substances (PFAS): Trends in mass spectrometric analysis for human biomonitoring and exposure patterns from recent global cohort studies
Per- and polyfluoroalkyl substances (PFAS) are widespread environmental contaminants that have been shown to contribute to human exposure, thereby raising a range of health concerns. In this context, human biomonitoring is essential for linking exposure levels of PFAS with their potential health risks. Mass spectrometry-based analytical techniques have been extensively adopted for the evaluation of PFAS levels across various cohorts. However, challenges arising from the use of biological samples (e.g., plasma, serum, urine, etc.) necessitate ongoing research and refinement of analytical methodologies. This review provides an overview of current trends in mass spectrometry-based approaches for human biomonitoring of PFAS, including sample collection and preparation, and instrumental techniques. We also explore analytical strategies to overcome challenges in obtaining PFAS-free blank matrices and address the risk of background contamination. Moreover, this review examines differing PFAS exposure patterns across regions by analyzing recent international cohort studies, specifically those conducted in the US and China over the past five years. Accordingly, several key research gaps in biomonitoring studies that need to be addressed moving forward are highlighted.
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来源期刊
Environment International
Environment International 环境科学-环境科学
CiteScore
21.90
自引率
3.40%
发文量
734
审稿时长
2.8 months
期刊介绍: Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.
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