Yue Wu, Weiying Xu, Guoyan Zhao, Ziyao Lei, Kui Li, Jiyun Liu, Shijia Huang, Junli Wang, Xiangbin Zhong, Xin Yin, Yuandong Wang, Haochen Zhang, Yang He, Zian Ye, Yonggang Meng, Xiaoyu Chang, Hui Lin, Xin Wang, Yuanyuan Gao, Jijie Chai, Jane E. Parker, Yiwen Deng, Yu Zhang, Mingjun Gao, Zuhua He
{"title":"一种典型蛋白复合物控制着免疫平衡和多种病原体的抵抗力","authors":"Yue Wu, Weiying Xu, Guoyan Zhao, Ziyao Lei, Kui Li, Jiyun Liu, Shijia Huang, Junli Wang, Xiangbin Zhong, Xin Yin, Yuandong Wang, Haochen Zhang, Yang He, Zian Ye, Yonggang Meng, Xiaoyu Chang, Hui Lin, Xin Wang, Yuanyuan Gao, Jijie Chai, Jane E. Parker, Yiwen Deng, Yu Zhang, Mingjun Gao, Zuhua He","doi":"10.1126/science.adr2138","DOIUrl":null,"url":null,"abstract":"The Ca <jats:sup>2+</jats:sup> sensor, ROD1, is a master regulator of immunity in rice. By screening suppressors of <jats:italic>rod1</jats:italic> mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in <jats:italic>OsTIR</jats:italic> ( <jats:italic>TIR-only protein</jats:italic> ), <jats:italic>OsEDS1</jats:italic> ( <jats:italic>Enhanced Disease Susceptibility 1</jats:italic> ), <jats:italic>OsPAD4</jats:italic> ( <jats:italic>Phytoalexin Deficient 4</jats:italic> ), and <jats:italic>OsADR1</jats:italic> ( <jats:italic>Activated Disease Resistance 1</jats:italic> ) all abolish enhanced disease resistance of <jats:italic>rod1</jats:italic> plants. OsTIR catalyzes the production of second messengers 2′-(5′′-phosphoribosyl)-5′-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity while mutation of <jats:italic>ROD1</jats:italic> leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice.","PeriodicalId":21678,"journal":{"name":"Science","volume":"69 1","pages":""},"PeriodicalIF":44.7000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A canonical protein complex controls immune homeostasis and multipathogen resistance\",\"authors\":\"Yue Wu, Weiying Xu, Guoyan Zhao, Ziyao Lei, Kui Li, Jiyun Liu, Shijia Huang, Junli Wang, Xiangbin Zhong, Xin Yin, Yuandong Wang, Haochen Zhang, Yang He, Zian Ye, Yonggang Meng, Xiaoyu Chang, Hui Lin, Xin Wang, Yuanyuan Gao, Jijie Chai, Jane E. Parker, Yiwen Deng, Yu Zhang, Mingjun Gao, Zuhua He\",\"doi\":\"10.1126/science.adr2138\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The Ca <jats:sup>2+</jats:sup> sensor, ROD1, is a master regulator of immunity in rice. By screening suppressors of <jats:italic>rod1</jats:italic> mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in <jats:italic>OsTIR</jats:italic> ( <jats:italic>TIR-only protein</jats:italic> ), <jats:italic>OsEDS1</jats:italic> ( <jats:italic>Enhanced Disease Susceptibility 1</jats:italic> ), <jats:italic>OsPAD4</jats:italic> ( <jats:italic>Phytoalexin Deficient 4</jats:italic> ), and <jats:italic>OsADR1</jats:italic> ( <jats:italic>Activated Disease Resistance 1</jats:italic> ) all abolish enhanced disease resistance of <jats:italic>rod1</jats:italic> plants. OsTIR catalyzes the production of second messengers 2′-(5′′-phosphoribosyl)-5′-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity while mutation of <jats:italic>ROD1</jats:italic> leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice.\",\"PeriodicalId\":21678,\"journal\":{\"name\":\"Science\",\"volume\":\"69 1\",\"pages\":\"\"},\"PeriodicalIF\":44.7000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Science\",\"FirstCategoryId\":\"103\",\"ListUrlMain\":\"https://doi.org/10.1126/science.adr2138\",\"RegionNum\":1,\"RegionCategory\":\"综合性期刊\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"MULTIDISCIPLINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Science","FirstCategoryId":"103","ListUrlMain":"https://doi.org/10.1126/science.adr2138","RegionNum":1,"RegionCategory":"综合性期刊","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"MULTIDISCIPLINARY SCIENCES","Score":null,"Total":0}
A canonical protein complex controls immune homeostasis and multipathogen resistance
The Ca 2+ sensor, ROD1, is a master regulator of immunity in rice. By screening suppressors of rod1 mutants, we show that ROD1 governs immune homeostasis by surveilling the activation of a canonical immune pathway. Mutations in OsTIR ( TIR-only protein ), OsEDS1 ( Enhanced Disease Susceptibility 1 ), OsPAD4 ( Phytoalexin Deficient 4 ), and OsADR1 ( Activated Disease Resistance 1 ) all abolish enhanced disease resistance of rod1 plants. OsTIR catalyzes the production of second messengers 2′-(5′′-phosphoribosyl)-5′-adenosine monophosphate (pRib-AMP) and diphosphate (pRib-ADP), which trigger formation of an OsEDS1-OsPAD4-OsADR1 (EPA) immune complex. ROD1 interacts with OsTIR and inhibits its enzymatic activity while mutation of ROD1 leads to constitutive activation of the EPA complex. Thus, we unveil an immune network that fine-tunes immune homeostasis and multipathogen resistance in rice.
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