{"title":"糖代谢异常和肝脏脂质含量影响肥胖症患者胰岛素抵抗与肝脏线粒体功能之间的联系 - 作者回复","authors":"Sabine Kahl, Michael Roden","doi":"10.1016/j.jhep.2024.11.003","DOIUrl":null,"url":null,"abstract":"<h2>Section snippets</h2><section><section><h2>Financial suppport</h2>The research of the authors is supported in part by grants from the German Federal Ministry of Health (BMG), the Ministry of Culture and Science of the State North Rhine Westphalia (MKW NRW) to DDZ, and the German Federal Ministry of Education and Research (BMBF) and the MKW NRW to German Center for Diabetes Research (DZD e. V.). The research of M.R. is supported by grants from the European Community (HORIZON-HLTH-2022-STAYHLTH-02-01: Panel A) to the INTERCEPT-T2D consortium, the German Science</section></section><section><section><h2>Author contributions</h2>S.K. drafted the manuscript. S.K. and M.R. revised and approve the final version of the manuscript. M.R. is the guarantor of this work, with full access to all data and analyses related to the content of this article.</section></section><section><section><h2>ClinTrials.gov identifier</h2>NCT01477957We thank Xiyin Yang and Qiang Hu for their interest in our article [1], which investigated the association of whole-body insulin sensitivity and hepatic OXPHOS capacity in people with obesity grade 3. We would like to take the opportunity to address their comments on our study.First, the prospective BARIA-DDZ study was designed to assess metabolic changes with one focus on different features of hepatic mitochondrial function in people with obesity. For this purpose, we developed a</section></section><section><section><h2>Declaration of Competing Interest</h2>M.R. received lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). No conflicts of interest, financial or otherwise, are declared by the other authors.</section></section>","PeriodicalId":15888,"journal":{"name":"Journal of Hepatology","volume":"18 1","pages":""},"PeriodicalIF":26.8000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Dysglycemia and liver lipid content influence the link between insulin resistance and liver mitochondrial function in obesity – Author’s reply\",\"authors\":\"Sabine Kahl, Michael Roden\",\"doi\":\"10.1016/j.jhep.2024.11.003\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<h2>Section snippets</h2><section><section><h2>Financial suppport</h2>The research of the authors is supported in part by grants from the German Federal Ministry of Health (BMG), the Ministry of Culture and Science of the State North Rhine Westphalia (MKW NRW) to DDZ, and the German Federal Ministry of Education and Research (BMBF) and the MKW NRW to German Center for Diabetes Research (DZD e. V.). The research of M.R. is supported by grants from the European Community (HORIZON-HLTH-2022-STAYHLTH-02-01: Panel A) to the INTERCEPT-T2D consortium, the German Science</section></section><section><section><h2>Author contributions</h2>S.K. drafted the manuscript. S.K. and M.R. revised and approve the final version of the manuscript. M.R. is the guarantor of this work, with full access to all data and analyses related to the content of this article.</section></section><section><section><h2>ClinTrials.gov identifier</h2>NCT01477957We thank Xiyin Yang and Qiang Hu for their interest in our article [1], which investigated the association of whole-body insulin sensitivity and hepatic OXPHOS capacity in people with obesity grade 3. We would like to take the opportunity to address their comments on our study.First, the prospective BARIA-DDZ study was designed to assess metabolic changes with one focus on different features of hepatic mitochondrial function in people with obesity. For this purpose, we developed a</section></section><section><section><h2>Declaration of Competing Interest</h2>M.R. received lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). No conflicts of interest, financial or otherwise, are declared by the other authors.</section></section>\",\"PeriodicalId\":15888,\"journal\":{\"name\":\"Journal of Hepatology\",\"volume\":\"18 1\",\"pages\":\"\"},\"PeriodicalIF\":26.8000,\"publicationDate\":\"2024-11-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Hepatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1016/j.jhep.2024.11.003\",\"RegionNum\":1,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Hepatology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1016/j.jhep.2024.11.003","RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}
Dysglycemia and liver lipid content influence the link between insulin resistance and liver mitochondrial function in obesity – Author’s reply
Section snippets
Financial suppport
The research of the authors is supported in part by grants from the German Federal Ministry of Health (BMG), the Ministry of Culture and Science of the State North Rhine Westphalia (MKW NRW) to DDZ, and the German Federal Ministry of Education and Research (BMBF) and the MKW NRW to German Center for Diabetes Research (DZD e. V.). The research of M.R. is supported by grants from the European Community (HORIZON-HLTH-2022-STAYHLTH-02-01: Panel A) to the INTERCEPT-T2D consortium, the German Science
Author contributions
S.K. drafted the manuscript. S.K. and M.R. revised and approve the final version of the manuscript. M.R. is the guarantor of this work, with full access to all data and analyses related to the content of this article.
ClinTrials.gov identifier
NCT01477957We thank Xiyin Yang and Qiang Hu for their interest in our article [1], which investigated the association of whole-body insulin sensitivity and hepatic OXPHOS capacity in people with obesity grade 3. We would like to take the opportunity to address their comments on our study.First, the prospective BARIA-DDZ study was designed to assess metabolic changes with one focus on different features of hepatic mitochondrial function in people with obesity. For this purpose, we developed a
Declaration of Competing Interest
M.R. received lecture fees or served on advisory boards for AstraZeneca, Echosens, Eli Lilly, Madrigal, Merck-MSD, Novo Nordisk and Target RWE and performed investigator-initiated research with support from Boehringer Ingelheim, Novo Nordisk and Nutricia/Danone to the German Diabetes Center (DDZ). No conflicts of interest, financial or otherwise, are declared by the other authors.
期刊介绍：
The Journal of Hepatology is the official publication of the European Association for the Study of the Liver (EASL). It is dedicated to presenting clinical and basic research in the field of hepatology through original papers, reviews, case reports, and letters to the Editor. The Journal is published in English and may consider supplements that pass an editorial review.
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