Scandium‐Catalyzed Fischer Indole Synthesis: A Highly Efficient Construction of Complicated Indoles

Herein, we report an efficient scandium‐catalytic reaction protocol for the classical Fischer indole synthesis, which can tolerate a wide variety of polycyclic substrates and allow us to easily construct complex indole structures in high yields for most cases. Moreover, in order to demonstrate the reaction efficacy, we also synthesized two quinazolinone‐containing natural alkaloids, their analog, as well as an anticancer indenoindolone compound.