吃还是不吃

IF 17.3 1区 生物学 Q1 CELL BIOLOGY Nature Cell Biology Pub Date : 2024-11-11 DOI:10.1038/s41556-024-01560-2
Stylianos Lefkopoulos
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引用次数: 0

摘要

在发育过程中,造血干细胞和祖细胞(HSPCs)会产生高水平的钙网织蛋白(calreticulin),从而引发它们被巨噬细胞吞噬。Pessoa Rodrigues等人对人类细胞进行了全基因组筛选,发现Toll样受体3(Toll-like receptor 3,TLR3)能调节 "别吃我 "信号(即B2M)的表达。作者随后用斑马鱼作为模型,结果表明,TLR3的缺失会减少B2m+ HSPC的数量,并增强巨噬细胞对HSPC的吞噬。HSPC 上的 B2m 保护它们在胚胎中不受吞噬,并影响成年 HSPC 的克隆性。通过一系列分析和功能实验,研究人员最终提出了这样一个模型:HSPC 中的内源性重复元件会触发 TLR3 信号,从而促进 B2M 的表达;反过来,HSPC 表面的 B2M 又会阻止巨噬细胞对 HSPC 的吞噬。最后,研究人员提出了哺乳动物潜在保护的证据。
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To eat or not to eat
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来源期刊
Nature Cell Biology
Nature Cell Biology 生物-细胞生物学
CiteScore
28.40
自引率
0.90%
发文量
219
审稿时长
3 months
期刊介绍: Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology
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