一种 GSDMD 激动剂能增强特异性抗肿瘤免疫力

IF 28.1 1区生物学 Q1 CELL BIOLOGY Cell Research Pub Date : 2024-11-13 DOI:10.1038/s41422-024-01051-x

Yingying Zhang, Jiahuai Han

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引用次数: 0

摘要

多项研究表明，激活气蛋白和诱导热蛋白沉积在抗肿瘤免疫中起着有益的作用；然而，如何特异而有效地激活癌细胞死亡，同时最大限度地减少对宿主细胞的毒性，这一问题仍未得到解决。在最近发表于《细胞》（Cell）的一篇论文中，Wu 和 Lieberman 小组发现了一种 GSDMD 激动剂，它能在癌细胞中诱导低水平的热蛋白沉积，而不在宿主细胞中诱导低水平的热蛋白沉积，这为癌症疫苗的开发以及与检查点阻断相结合的治疗提供了潜在的应用前景。

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A GSDMD agonist boosts specific antitumor immunity

The beneficial role of gasdermin activation and pyroptosis induction in antitumor immunity has been implicated by several studies; however, the question of how to specifically and efficiently activate cancer cell death while minimizing toxicity to host cells remains unsolved. In a recent paper published in Cell, Wu and Lieberman groups identified a GSDMD agonist that can induce low-level pyroptosis in cancer cells but not in host cells, offering potential applications in cancer vaccine development and therapy in combination with checkpoint blockade.

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来源期刊

Cell Research 生物-细胞生物学

CiteScore

53.90

自引率

0.70%

发文量

2420

审稿时长

2.3 months

期刊介绍： Cell Research (CR) is an international journal published by Springer Nature in partnership with the Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences (CAS). It focuses on publishing original research articles and reviews in various areas of life sciences, particularly those related to molecular and cell biology. The journal covers a broad range of topics including cell growth, differentiation, and apoptosis; signal transduction; stem cell biology and development; chromatin, epigenetics, and transcription; RNA biology; structural and molecular biology; cancer biology and metabolism; immunity and molecular pathogenesis; molecular and cellular neuroscience; plant molecular and cell biology; and omics, system biology, and synthetic biology. CR is recognized as China's best international journal in life sciences and is part of Springer Nature's prestigious family of Molecular Cell Biology journals.

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