玻璃化卵母细胞捐献者和男性受体伙伴的空气污染暴露与受精和胚胎质量的关系

IF 10.3 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environment International Pub Date : 2024-11-01 DOI:10.1016/j.envint.2024.109147
Sarah LaPointe , Jaqueline C Lee , Zsolt P Nagy , Daniel B Shapiro , Howard H Chang , Yifeng Wang , Armistead G Russell , Heather S Hipp , Audrey J Gaskins
{"title":"玻璃化卵母细胞捐献者和男性受体伙伴的空气污染暴露与受精和胚胎质量的关系","authors":"Sarah LaPointe ,&nbsp;Jaqueline C Lee ,&nbsp;Zsolt P Nagy ,&nbsp;Daniel B Shapiro ,&nbsp;Howard H Chang ,&nbsp;Yifeng Wang ,&nbsp;Armistead G Russell ,&nbsp;Heather S Hipp ,&nbsp;Audrey J Gaskins","doi":"10.1016/j.envint.2024.109147","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Studies on air pollution and outcomes of <em>in vitro</em> fertilization (IVF) have focused on couples undergoing autologous IVF, in which it is challenging to disentangle maternal and paternal exposures during gametogenesis. We sought to evaluate the independent associations between air pollution exposure during oogenesis and spermatogenesis on fertilization and embryo quality in non-identified donor oocyte IVF cycles.</div></div><div><h3>Methods</h3><div>Our study included 500 oocyte donors and 915 male recipient partners who contributed 1,095 oocyte thaw cycles (2008–2019). Daily ambient air pollutant exposure was estimated using spatio-temporal models based on residential address and averaged over folliculogenesis (i.e., three months prior to initiation of controlled ovarian stimulation), controlled ovarian stimulation, and spermatogenesis (i.e., 72 days prior to oocyte thaw). We used multivariable generalized estimating equations to estimate the adjusted odds ratios (aOR) and 95 % confidence intervals (CI) for an interquartile range increase in pollutant exposure in relation to the proportion of oocytes surviving thaw, oocytes fertilized, and usable embryos.</div></div><div><h3>Results</h3><div>Oocyte donors with higher exposure to organic carbon (OC) (aOR = 0.86 95 %CI 0.79,0.94) and particulate matter &lt; 10 µm (aOR = 0.69 95 %CI 0.54,0.90) during folliculogenesis had a lower proportion of oocytes surviving thaw. During ovarian stimulation, higher particulate matter &lt; 2.5 µm (aOR = 0.78 95 %CI 0.66, 0.91), nitrate (aOR = 0.83 95 % CI 0.69,0.99), and OC (aOR = 0.86 95 % CI 0.80,0.93) exposure was associated with a lower proportion of surviving oocytes while nitrogen dioxide (aOR = 1.11 95 %CI 1.00,1.23) and ozone (aOR = 1.19 95 %CI 1.04,1.37) exposure was associated with a higher proportion of fertilized oocytes and usable embryos. Elemental carbon (aOR = 0.93 95 %CI 0.87,1.00) and OC (aOR = 0.95 95 %CI 0.90,1.00) exposure during spermatogenesis was associated with a slightly lower proportion of usable embryos. On the day of oocyte thaw, higher ambient OC at the IVF clinic was associated with lower oocyte survival and higher ozone was associated with lower fertilization.</div></div><div><h3>Conclusions</h3><div>Both maternal and paternal air pollution exposures during gametogenesis have independent, largely detrimental, effects on early embryological outcomes.</div></div>","PeriodicalId":308,"journal":{"name":"Environment International","volume":"193 ","pages":"Article 109147"},"PeriodicalIF":10.3000,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality\",\"authors\":\"Sarah LaPointe ,&nbsp;Jaqueline C Lee ,&nbsp;Zsolt P Nagy ,&nbsp;Daniel B Shapiro ,&nbsp;Howard H Chang ,&nbsp;Yifeng Wang ,&nbsp;Armistead G Russell ,&nbsp;Heather S Hipp ,&nbsp;Audrey J Gaskins\",\"doi\":\"10.1016/j.envint.2024.109147\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Background</h3><div>Studies on air pollution and outcomes of <em>in vitro</em> fertilization (IVF) have focused on couples undergoing autologous IVF, in which it is challenging to disentangle maternal and paternal exposures during gametogenesis. We sought to evaluate the independent associations between air pollution exposure during oogenesis and spermatogenesis on fertilization and embryo quality in non-identified donor oocyte IVF cycles.</div></div><div><h3>Methods</h3><div>Our study included 500 oocyte donors and 915 male recipient partners who contributed 1,095 oocyte thaw cycles (2008–2019). Daily ambient air pollutant exposure was estimated using spatio-temporal models based on residential address and averaged over folliculogenesis (i.e., three months prior to initiation of controlled ovarian stimulation), controlled ovarian stimulation, and spermatogenesis (i.e., 72 days prior to oocyte thaw). We used multivariable generalized estimating equations to estimate the adjusted odds ratios (aOR) and 95 % confidence intervals (CI) for an interquartile range increase in pollutant exposure in relation to the proportion of oocytes surviving thaw, oocytes fertilized, and usable embryos.</div></div><div><h3>Results</h3><div>Oocyte donors with higher exposure to organic carbon (OC) (aOR = 0.86 95 %CI 0.79,0.94) and particulate matter &lt; 10 µm (aOR = 0.69 95 %CI 0.54,0.90) during folliculogenesis had a lower proportion of oocytes surviving thaw. During ovarian stimulation, higher particulate matter &lt; 2.5 µm (aOR = 0.78 95 %CI 0.66, 0.91), nitrate (aOR = 0.83 95 % CI 0.69,0.99), and OC (aOR = 0.86 95 % CI 0.80,0.93) exposure was associated with a lower proportion of surviving oocytes while nitrogen dioxide (aOR = 1.11 95 %CI 1.00,1.23) and ozone (aOR = 1.19 95 %CI 1.04,1.37) exposure was associated with a higher proportion of fertilized oocytes and usable embryos. Elemental carbon (aOR = 0.93 95 %CI 0.87,1.00) and OC (aOR = 0.95 95 %CI 0.90,1.00) exposure during spermatogenesis was associated with a slightly lower proportion of usable embryos. On the day of oocyte thaw, higher ambient OC at the IVF clinic was associated with lower oocyte survival and higher ozone was associated with lower fertilization.</div></div><div><h3>Conclusions</h3><div>Both maternal and paternal air pollution exposures during gametogenesis have independent, largely detrimental, effects on early embryological outcomes.</div></div>\",\"PeriodicalId\":308,\"journal\":{\"name\":\"Environment International\",\"volume\":\"193 \",\"pages\":\"Article 109147\"},\"PeriodicalIF\":10.3000,\"publicationDate\":\"2024-11-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Environment International\",\"FirstCategoryId\":\"93\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0160412024007335\",\"RegionNum\":1,\"RegionCategory\":\"环境科学与生态学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"ENVIRONMENTAL SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Environment International","FirstCategoryId":"93","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0160412024007335","RegionNum":1,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENVIRONMENTAL SCIENCES","Score":null,"Total":0}
引用次数: 0

摘要

背景有关空气污染和体外受精(IVF)结果的研究主要集中在接受自体体外受精的夫妇身上,在这种情况下,很难区分配子发生过程中母体和父体的暴露。我们试图评估在非鉴定捐献者卵母细胞试管婴儿周期中,卵子生成和精子生成过程中的空气污染暴露与受精和胚胎质量之间的独立关联。方法我们的研究纳入了 500 名卵母细胞捐献者和 915 名男性受者伴侣,他们共捐献了 1,095 个卵母细胞解冻周期(2008-2019 年)。我们使用基于居住地址的时空模型估算了每日环境空气污染物暴露量,并对卵泡生成(即开始控制性卵巢刺激前三个月)、控制性卵巢刺激和精子生成(即卵母细胞解冻前 72 天)进行了平均。我们使用多变量广义估计方程估算了污染物暴露量在四分位数范围内增加时,与卵母细胞解冻存活率、卵母细胞受精率和可用胚胎比例相关的调整后几率比(aOR)和 95 % 置信区间(CI)。结果在卵泡生成过程中接触有机碳(OC)(aOR = 0.86 95 %CI 0.79,0.94)和颗粒物 < 10 µm(aOR = 0.69 95 %CI 0.54,0.90)较多的卵母细胞捐献者的卵母细胞解冻存活比例较低。在卵巢刺激过程中,较高的微粒物质< 2.5 µm(aOR = 0.78 95 %CI 0.66,0.91)、硝酸盐(aOR = 0.83 95 %CI 0.69,0.99)和 OC(aOR = 0.86 95 %CI 0.80,0.93)与卵母细胞存活率较低有关。93)与存活卵母细胞比例较低有关,而二氧化氮(aOR = 1.11 95 %CI 1.00,1.23)和臭氧(aOR = 1.19 95 %CI 1.04,1.37)与受精卵母细胞和可用胚胎比例较高有关。在精子发生过程中接触碳元素(aOR = 0.93 95 %CI 0.87,1.00)和臭氧(aOR = 0.95 95 %CI 0.90,1.00)与可用胚胎比例略低有关。在卵母细胞解冻当天,IVF 诊所环境中较高的 OC 与较低的卵母细胞存活率有关,而较高的臭氧与较低的受精率有关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
查看原文
分享 分享
微信好友 朋友圈 QQ好友 复制链接
本刊更多论文
Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality

Background

Studies on air pollution and outcomes of in vitro fertilization (IVF) have focused on couples undergoing autologous IVF, in which it is challenging to disentangle maternal and paternal exposures during gametogenesis. We sought to evaluate the independent associations between air pollution exposure during oogenesis and spermatogenesis on fertilization and embryo quality in non-identified donor oocyte IVF cycles.

Methods

Our study included 500 oocyte donors and 915 male recipient partners who contributed 1,095 oocyte thaw cycles (2008–2019). Daily ambient air pollutant exposure was estimated using spatio-temporal models based on residential address and averaged over folliculogenesis (i.e., three months prior to initiation of controlled ovarian stimulation), controlled ovarian stimulation, and spermatogenesis (i.e., 72 days prior to oocyte thaw). We used multivariable generalized estimating equations to estimate the adjusted odds ratios (aOR) and 95 % confidence intervals (CI) for an interquartile range increase in pollutant exposure in relation to the proportion of oocytes surviving thaw, oocytes fertilized, and usable embryos.

Results

Oocyte donors with higher exposure to organic carbon (OC) (aOR = 0.86 95 %CI 0.79,0.94) and particulate matter < 10 µm (aOR = 0.69 95 %CI 0.54,0.90) during folliculogenesis had a lower proportion of oocytes surviving thaw. During ovarian stimulation, higher particulate matter < 2.5 µm (aOR = 0.78 95 %CI 0.66, 0.91), nitrate (aOR = 0.83 95 % CI 0.69,0.99), and OC (aOR = 0.86 95 % CI 0.80,0.93) exposure was associated with a lower proportion of surviving oocytes while nitrogen dioxide (aOR = 1.11 95 %CI 1.00,1.23) and ozone (aOR = 1.19 95 %CI 1.04,1.37) exposure was associated with a higher proportion of fertilized oocytes and usable embryos. Elemental carbon (aOR = 0.93 95 %CI 0.87,1.00) and OC (aOR = 0.95 95 %CI 0.90,1.00) exposure during spermatogenesis was associated with a slightly lower proportion of usable embryos. On the day of oocyte thaw, higher ambient OC at the IVF clinic was associated with lower oocyte survival and higher ozone was associated with lower fertilization.

Conclusions

Both maternal and paternal air pollution exposures during gametogenesis have independent, largely detrimental, effects on early embryological outcomes.
求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Environment International
Environment International 环境科学-环境科学
CiteScore
21.90
自引率
3.40%
发文量
734
审稿时长
2.8 months
期刊介绍: Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.
期刊最新文献
Analysis of the stereoselective fate and toxicity of penflufen in the water-sediment system for risk reduction Uncovering global risk to human and ecosystem health from pesticides in agricultural surface water using a machine learning approach Low dose exposure to dioxins alters hepatic energy metabolism and steatotic liver disease development in a sex-specific manner Seasonal dynamics of the phage-bacterium linkage and associated antibiotic resistome in airborne PM2.5 of urban areas Assessment of risk for aromatic hydrocarbons resulting from subsea Blowouts: A case study in eastern Canada
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
已复制链接
已复制链接
快去分享给好友吧!
我知道了
×
扫码分享
扫码分享
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1