玻璃化卵母细胞捐献者和男性受体伙伴的空气污染暴露与受精和胚胎质量的关系

IF 10.3 1区 环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES Environment International Pub Date : 2024-11-13 DOI:10.1016/j.envint.2024.109147
Sarah LaPointe, Jaqueline C Lee, Zsolt P Nagy, Daniel B Shapiro, Howard H Chang, Yifeng Wang, Armistead G Russell, Heather S Hipp, Audrey J Gaskins
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引用次数: 0

摘要

背景有关空气污染和体外受精(IVF)结果的研究主要集中在接受自体体外受精的夫妇身上,在这种情况下,很难区分配子发生过程中母体和父体的暴露。我们试图评估在非鉴定捐献者卵母细胞试管婴儿周期中,卵子生成和精子生成过程中的空气污染暴露与受精和胚胎质量之间的独立关联。方法我们的研究纳入了 500 名卵母细胞捐献者和 915 名男性受者伴侣,他们共捐献了 1,095 个卵母细胞解冻周期(2008-2019 年)。我们使用基于居住地址的时空模型估算了每日环境空气污染物暴露量,并对卵泡生成(即开始控制性卵巢刺激前三个月)、控制性卵巢刺激和精子生成(即卵母细胞解冻前 72 天)进行了平均。我们使用多变量广义估计方程估算了污染物暴露量在四分位数范围内增加时,与卵母细胞解冻存活率、卵母细胞受精率和可用胚胎比例相关的调整后几率比(aOR)和 95 % 置信区间(CI)。结果在卵泡生成过程中接触有机碳(OC)(aOR = 0.86 95 %CI 0.79,0.94)和颗粒物 < 10 µm(aOR = 0.69 95 %CI 0.54,0.90)较多的卵母细胞捐献者的卵母细胞解冻存活比例较低。在卵巢刺激过程中,较高的微粒物质< 2.5 µm(aOR = 0.78 95 %CI 0.66,0.91)、硝酸盐(aOR = 0.83 95 %CI 0.69,0.99)和 OC(aOR = 0.86 95 %CI 0.80,0.93)与卵母细胞存活率较低有关。93)与存活卵母细胞比例较低有关,而二氧化氮(aOR = 1.11 95 %CI 1.00,1.23)和臭氧(aOR = 1.19 95 %CI 1.04,1.37)与受精卵母细胞和可用胚胎比例较高有关。在精子发生过程中接触碳元素(aOR = 0.93 95 %CI 0.87,1.00)和臭氧(aOR = 0.95 95 %CI 0.90,1.00)与可用胚胎比例略低有关。在卵母细胞解冻当天,IVF 诊所环境中较高的 OC 与较低的卵母细胞存活率有关,而较高的臭氧与较低的受精率有关。
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Air pollution exposure in vitrified oocyte donors and male recipient partners in relation to fertilization and embryo quality

Background

Studies on air pollution and outcomes of in vitro fertilization (IVF) have focused on couples undergoing autologous IVF, in which it is challenging to disentangle maternal and paternal exposures during gametogenesis. We sought to evaluate the independent associations between air pollution exposure during oogenesis and spermatogenesis on fertilization and embryo quality in non-identified donor oocyte IVF cycles.

Methods

Our study included 500 oocyte donors and 915 male recipient partners who contributed 1,095 oocyte thaw cycles (2008–2019). Daily ambient air pollutant exposure was estimated using spatio-temporal models based on residential address and averaged over folliculogenesis (i.e., three months prior to initiation of controlled ovarian stimulation), controlled ovarian stimulation, and spermatogenesis (i.e., 72 days prior to oocyte thaw). We used multivariable generalized estimating equations to estimate the adjusted odds ratios (aOR) and 95 % confidence intervals (CI) for an interquartile range increase in pollutant exposure in relation to the proportion of oocytes surviving thaw, oocytes fertilized, and usable embryos.

Results

Oocyte donors with higher exposure to organic carbon (OC) (aOR = 0.86 95 %CI 0.79,0.94) and particulate matter < 10 µm (aOR = 0.69 95 %CI 0.54,0.90) during folliculogenesis had a lower proportion of oocytes surviving thaw. During ovarian stimulation, higher particulate matter < 2.5 µm (aOR = 0.78 95 %CI 0.66, 0.91), nitrate (aOR = 0.83 95 % CI 0.69,0.99), and OC (aOR = 0.86 95 % CI 0.80,0.93) exposure was associated with a lower proportion of surviving oocytes while nitrogen dioxide (aOR = 1.11 95 %CI 1.00,1.23) and ozone (aOR = 1.19 95 %CI 1.04,1.37) exposure was associated with a higher proportion of fertilized oocytes and usable embryos. Elemental carbon (aOR = 0.93 95 %CI 0.87,1.00) and OC (aOR = 0.95 95 %CI 0.90,1.00) exposure during spermatogenesis was associated with a slightly lower proportion of usable embryos. On the day of oocyte thaw, higher ambient OC at the IVF clinic was associated with lower oocyte survival and higher ozone was associated with lower fertilization.

Conclusions

Both maternal and paternal air pollution exposures during gametogenesis have independent, largely detrimental, effects on early embryological outcomes.
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来源期刊
Environment International
Environment International 环境科学-环境科学
CiteScore
21.90
自引率
3.40%
发文量
734
审稿时长
2.8 months
期刊介绍: Environmental Health publishes manuscripts focusing on critical aspects of environmental and occupational medicine, including studies in toxicology and epidemiology, to illuminate the human health implications of exposure to environmental hazards. The journal adopts an open-access model and practices open peer review. It caters to scientists and practitioners across all environmental science domains, directly or indirectly impacting human health and well-being. With a commitment to enhancing the prevention of environmentally-related health risks, Environmental Health serves as a public health journal for the community and scientists engaged in matters of public health significance concerning the environment.
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