{"title":"利用机理洞察力设计水解纳米酶","authors":"Ziqi Zhang, Zhen Chen, Yiqing Zhang, Zichang Wang, Dehong Chen, Jing Liu, Zhiling Zhu","doi":"10.1016/j.ccr.2024.216340","DOIUrl":null,"url":null,"abstract":"Hydrolytic nanozymes have emerged as promising candidates for diverse applications across pharmaceuticals, chemicals, environmental remediation, food, and paper industries. Despite their potential, research on hydrolytic nanozymes remains significantly underdeveloped, accounting for only 14.4 % of all nanozyme studies (1256 papers out of 8737). A critical gap exists in understanding the catalytic mechanisms and design strategies of these nanozymes, hindering their theoretical advancement and practical utilization. This review aims to address this gap by systematically organizing and summarizing the catalytic mechanisms of hydrolytic nanozymes, categorized by structural composition and substrate type, along with the design approaches ranging from biomimetic strategies to the cutting-edge data-driven methods, providing theoretical insights to guide the rational design and efficient development of hydrolytic nanozymes. Furthermore, this review offers perspectives on the future prospects and challenges in the field, aiming to inspire further research and innovation in this rapidly advancing area.","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":null,"pages":null},"PeriodicalIF":20.3000,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Leveraging mechanistic insight to design hydrolytic nanozymes\",\"authors\":\"Ziqi Zhang, Zhen Chen, Yiqing Zhang, Zichang Wang, Dehong Chen, Jing Liu, Zhiling Zhu\",\"doi\":\"10.1016/j.ccr.2024.216340\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Hydrolytic nanozymes have emerged as promising candidates for diverse applications across pharmaceuticals, chemicals, environmental remediation, food, and paper industries. Despite their potential, research on hydrolytic nanozymes remains significantly underdeveloped, accounting for only 14.4 % of all nanozyme studies (1256 papers out of 8737). A critical gap exists in understanding the catalytic mechanisms and design strategies of these nanozymes, hindering their theoretical advancement and practical utilization. This review aims to address this gap by systematically organizing and summarizing the catalytic mechanisms of hydrolytic nanozymes, categorized by structural composition and substrate type, along with the design approaches ranging from biomimetic strategies to the cutting-edge data-driven methods, providing theoretical insights to guide the rational design and efficient development of hydrolytic nanozymes. Furthermore, this review offers perspectives on the future prospects and challenges in the field, aiming to inspire further research and innovation in this rapidly advancing area.\",\"PeriodicalId\":289,\"journal\":{\"name\":\"Coordination Chemistry Reviews\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":20.3000,\"publicationDate\":\"2024-11-13\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Coordination Chemistry Reviews\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1016/j.ccr.2024.216340\",\"RegionNum\":1,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CHEMISTRY, INORGANIC & NUCLEAR\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1016/j.ccr.2024.216340","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
Leveraging mechanistic insight to design hydrolytic nanozymes
Hydrolytic nanozymes have emerged as promising candidates for diverse applications across pharmaceuticals, chemicals, environmental remediation, food, and paper industries. Despite their potential, research on hydrolytic nanozymes remains significantly underdeveloped, accounting for only 14.4 % of all nanozyme studies (1256 papers out of 8737). A critical gap exists in understanding the catalytic mechanisms and design strategies of these nanozymes, hindering their theoretical advancement and practical utilization. This review aims to address this gap by systematically organizing and summarizing the catalytic mechanisms of hydrolytic nanozymes, categorized by structural composition and substrate type, along with the design approaches ranging from biomimetic strategies to the cutting-edge data-driven methods, providing theoretical insights to guide the rational design and efficient development of hydrolytic nanozymes. Furthermore, this review offers perspectives on the future prospects and challenges in the field, aiming to inspire further research and innovation in this rapidly advancing area.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.