人类单核细胞在衰老和骨髓增生异常肿瘤中的分子特征。

IF 4.5 3区医学 Q2 IMMUNOLOGY European Journal of Immunology Pub Date : 2024-11-08 DOI:10.1002/eji.202451387

Christina Maria Rimpa, Maria Grigoriou, Athanasios Tasis, Nikolaos Paschalidis, Anastasia Filia, Giannis Vatsellas, Panagiotis Papazoglou, Antonios Chatzigeorgiou, Chrysa Kymparidou, Menelaos Papoutselis, Christina Misidou, Theodoros Spyropoulos, Despoina Dimitriou, Haralampos Hatzikirou, Konstantinos Liapis, Eleftheria Lamprianidou, Ioannis Kotsianidis, Ioannis Mitroulis

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引用次数: 0

摘要

- 衰老会导致慢性炎症和免疫功能失调，从而增加罹患骨髓性恶性肿瘤（如 MDS 和 CMML）的风险。- 衰老和 MDS 都显示出单核细胞亚型和功能的改变。衰老促进炎症基因上调，而 MDS 则有利于抗原呈递，这反映了不同的免疫和疾病特异性适应。- MDS显示CD14+细胞的炎症活性降低，而CMML则显示炎症增强，这凸显了不同的疾病机制。

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Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms

• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML.

• Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations.

• MDS shows reduced inflammatory activity in CD14⁺ cells, whereas CMML exhibits heightened inflammation, highlighting distinct disease mechanisms.

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来源期刊

European Journal of Immunology 医学-免疫学

CiteScore

8.30

自引率

3.70%

发文量

224

审稿时长

2 months

期刊介绍： The European Journal of Immunology (EJI) is an official journal of EFIS. Established in 1971, EJI continues to serve the needs of the global immunology community covering basic, translational and clinical research, ranging from adaptive and innate immunity through to vaccines and immunotherapy, cancer, autoimmunity, allergy and more. Mechanistic insights and thought-provoking immunological findings are of interest, as are studies using the latest omics technologies. We offer fast track review for competitive situations, including recently scooped papers, format free submission, transparent and fair peer review and more as detailed in our policies.