Austin Yu, Trevor Poulson, Zachary Butler, Matthew Demetrious, Matthew Colman, Steven Gitelis, Alan T Blank
{"title":"边缘阳性和骨外扩展的软骨肉瘤对患者预后的影响","authors":"Austin Yu, Trevor Poulson, Zachary Butler, Matthew Demetrious, Matthew Colman, Steven Gitelis, Alan T Blank","doi":"10.1002/jso.27982","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Chondrosarcoma accounts for 20% of all bony sarcomas and may present with extraosseous extension (EOE). The presence of an extraosseous component, along with positive surgical margins, has been separately associated with increased risk of local recurrence and decreased survival. This study compared the outcomes between patients with EOE, EOE and positive margins, and a control chondrosarcoma cohort with neither feature.</p><p><strong>Methods: </strong>This was a retrospective review of 91 patients over a consecutive 13-year period. Data including treatment details and outcomes were included. Thirty-two patients had EOE of their chondrosarcoma, 7 patients had positive margins and EOE, and 52 chondrosarcoma patients had neither characteristic. Tumor characteristics, patient demographics, and overall survival, recurrence rates, and metastatic rates were compared among the three groups.</p><p><strong>Results: </strong>Patients with positive surgical margins and EOE were noted to have significantly higher resection grade, dedifferentiation on presentation, and use of adjuvant chemotherapy compared to control. Patients with EOE alone were noted to have significantly higher grade and use of adjuvant chemotherapy compared to control. Patients with positive surgical margins and EOE additionally had significantly higher rates of mortality, recurrence, and metastasis on survival analysis compared to control. However, patients with EOE alone did not have significantly different survival rates compared to control.</p><p><strong>Conclusion: </strong>This study is one of the first to analyze the survival impact of EOE with positive surgical margins in chondrosarcoma. The significance found in mortality, recurrence, and metastatic rates in this unique subgroup may warrant further longitudinal observation and dictate future treatment options.</p>","PeriodicalId":17111,"journal":{"name":"Journal of Surgical Oncology","volume":" ","pages":""},"PeriodicalIF":2.0000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"The Impact of Chondrosarcoma with Positive Margins and Extraosseous Extension on Patient Outcomes.\",\"authors\":\"Austin Yu, Trevor Poulson, Zachary Butler, Matthew Demetrious, Matthew Colman, Steven Gitelis, Alan T Blank\",\"doi\":\"10.1002/jso.27982\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Chondrosarcoma accounts for 20% of all bony sarcomas and may present with extraosseous extension (EOE). The presence of an extraosseous component, along with positive surgical margins, has been separately associated with increased risk of local recurrence and decreased survival. This study compared the outcomes between patients with EOE, EOE and positive margins, and a control chondrosarcoma cohort with neither feature.</p><p><strong>Methods: </strong>This was a retrospective review of 91 patients over a consecutive 13-year period. Data including treatment details and outcomes were included. Thirty-two patients had EOE of their chondrosarcoma, 7 patients had positive margins and EOE, and 52 chondrosarcoma patients had neither characteristic. Tumor characteristics, patient demographics, and overall survival, recurrence rates, and metastatic rates were compared among the three groups.</p><p><strong>Results: </strong>Patients with positive surgical margins and EOE were noted to have significantly higher resection grade, dedifferentiation on presentation, and use of adjuvant chemotherapy compared to control. Patients with EOE alone were noted to have significantly higher grade and use of adjuvant chemotherapy compared to control. Patients with positive surgical margins and EOE additionally had significantly higher rates of mortality, recurrence, and metastasis on survival analysis compared to control. However, patients with EOE alone did not have significantly different survival rates compared to control.</p><p><strong>Conclusion: </strong>This study is one of the first to analyze the survival impact of EOE with positive surgical margins in chondrosarcoma. The significance found in mortality, recurrence, and metastatic rates in this unique subgroup may warrant further longitudinal observation and dictate future treatment options.</p>\",\"PeriodicalId\":17111,\"journal\":{\"name\":\"Journal of Surgical Oncology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Surgical Oncology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1002/jso.27982\",\"RegionNum\":3,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"ONCOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Surgical Oncology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1002/jso.27982","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}
The Impact of Chondrosarcoma with Positive Margins and Extraosseous Extension on Patient Outcomes.
Background: Chondrosarcoma accounts for 20% of all bony sarcomas and may present with extraosseous extension (EOE). The presence of an extraosseous component, along with positive surgical margins, has been separately associated with increased risk of local recurrence and decreased survival. This study compared the outcomes between patients with EOE, EOE and positive margins, and a control chondrosarcoma cohort with neither feature.
Methods: This was a retrospective review of 91 patients over a consecutive 13-year period. Data including treatment details and outcomes were included. Thirty-two patients had EOE of their chondrosarcoma, 7 patients had positive margins and EOE, and 52 chondrosarcoma patients had neither characteristic. Tumor characteristics, patient demographics, and overall survival, recurrence rates, and metastatic rates were compared among the three groups.
Results: Patients with positive surgical margins and EOE were noted to have significantly higher resection grade, dedifferentiation on presentation, and use of adjuvant chemotherapy compared to control. Patients with EOE alone were noted to have significantly higher grade and use of adjuvant chemotherapy compared to control. Patients with positive surgical margins and EOE additionally had significantly higher rates of mortality, recurrence, and metastasis on survival analysis compared to control. However, patients with EOE alone did not have significantly different survival rates compared to control.
Conclusion: This study is one of the first to analyze the survival impact of EOE with positive surgical margins in chondrosarcoma. The significance found in mortality, recurrence, and metastatic rates in this unique subgroup may warrant further longitudinal observation and dictate future treatment options.
期刊介绍:
The Journal of Surgical Oncology offers peer-reviewed, original papers in the field of surgical oncology and broadly related surgical sciences, including reports on experimental and laboratory studies. As an international journal, the editors encourage participation from leading surgeons around the world. The JSO is the representative journal for the World Federation of Surgical Oncology Societies. Publishing 16 issues in 2 volumes each year, the journal accepts Research Articles, in-depth Reviews of timely interest, Letters to the Editor, and invited Editorials. Guest Editors from the JSO Editorial Board oversee multiple special Seminars issues each year. These Seminars include multifaceted Reviews on a particular topic or current issue in surgical oncology, which are invited from experts in the field.