个性化医疗时代的膀胱癌治疗:潜在放射敏感性生物标志物的全面回顾。

IF 3.4 Q2 MEDICINE, RESEARCH & EXPERIMENTAL Biomarker Insights Pub Date : 2024-11-06 eCollection Date: 2024-01-01 DOI:10.1177/11772719241297168
Charbel Feghaly, Rafka Challita, Hanine Bou Hadir, Tala Mobayed, Tarek Al Bitar, Mohammad Harbi, Hala Ghorayeb, Rana El-Hassan, Larry Bodgi
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引用次数: 0

摘要

膀胱癌是男性最常见的癌症之一。虽然膀胱切除术仍是主要的治疗方法,但放疗和化疗的进步凸显了保留膀胱策略的价值,这也能提高患者的生活质量。尽管取得了这些进步,但仍有约 20% 的患者可能因肿瘤放射抵抗而需要进行挽救性膀胱切除术。这凸显了开发放射敏感性预测测定的必要性。放疗通过诱导DNA损伤发挥作用,主要是通过DNA双链断裂,如果不及时修复,会严重影响治疗效果。除了激活DNA修复途径外,辐射反应还涉及肿瘤微环境、细胞死亡途径、免疫反应以及不同类型的细胞死亡和增殖受体。近年来,为患者量身定制治疗方案的个性化医疗在癌症治疗领域日益受到关注。化疗和放射敏感性预测测定的开发已成为癌症研究的重点。尽管这种检测方法对膀胱癌治疗有潜在影响,但目前仍没有可靠的检测方法能帮助临床医生和告知患者选择最佳治疗方法。本综述旨在重点介绍试图描述膀胱癌放射敏感性的研究,并讨论可用于开发膀胱癌放射敏感性预测测定的潜在生物标记物。
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Bladder Cancer Treatments in the Age of Personalized Medicine: A Comprehensive Review of Potential Radiosensitivity Biomarkers.

Bladder cancer is one of the most frequently diagnosed cancers in men. While cystectomy remains the primary treatment, advances in radiotherapy and chemotherapy have highlighted the value of bladder-preserving strategies, which can also enhance patients' quality of life. Despise these advances, around 20% of patients may still require salvage cystectomy due to tumor radioresistance. This underscores the need to develop radiosensitivity predictive assays. Radiotherapy acts by inducing DNA damage, primarily through DNA double-strand breaks, which can significantly affect treatment outcomes if left unrepaired. In addition to activating DNA repair pathways, the response to radiation also involves the tumor microenvironment, cell death pathways, immune responses and different types of cell death and proliferation receptors. In recent years, personalized medicine, which tailors treatments to individual patients, has gained increasing attention in cancer care. The development of chemo- and radiosensitivity predictive assays has become a key focus of cancer research. Despite the potential impact of such assays on bladder cancer treatment, there is still no reliable test that can help clinicians and informs patients in choosing the best treatment. This review aims to highlight studies that attempted to characterize bladder cancer radiosensitivity and to discuss the potential biomarkers that could be used to develop bladder cancer radiosensitivity predictive assays.

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来源期刊
Biomarker Insights
Biomarker Insights MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
6.00
自引率
0.00%
发文量
26
审稿时长
8 weeks
期刊介绍: An open access, peer reviewed electronic journal that covers all aspects of biomarker research and clinical applications.
期刊最新文献
Bladder Cancer Treatments in the Age of Personalized Medicine: A Comprehensive Review of Potential Radiosensitivity Biomarkers. Decreased Serum Insulin Receptor Messenger RNA Level in H. pylori IgG Seropositive Type 2 Diabetic Patients. Systematic Analysis and Insights Into the Mutation Spectrum and Ethnic Differences in ATP7B Mutations Associated With Wilson Disease. The Chromosome Passenger Complex (CPC) Components and Its Associated Pathways Are Promising Candidates to Differentiate Between Normosensitive and Radiosensitive ATM-Mutated Cells. D-dimer as a Predictive Biomarker of Response to Chemotherapy in Patients With Metastatic Breast Cancer.
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