Daniel O'Reilly, Charlotte Jones, Aisling Smith, David Mackin, Laura Mc Donald, John Quinn, Maeve O'Reilly, Aisling M Flinn, Ronan Leahy, David Williams, Jennifer Donnelly, David Corcoran
{"title":"2例母体CAR-T疗法治疗高级别B细胞淋巴瘤的新生儿结局","authors":"Daniel O'Reilly, Charlotte Jones, Aisling Smith, David Mackin, Laura Mc Donald, John Quinn, Maeve O'Reilly, Aisling M Flinn, Ronan Leahy, David Williams, Jennifer Donnelly, David Corcoran","doi":"10.1159/000542016","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>Chimeric antigen receptor T cells (CAR-Ts) targeting CD19 represent a significant advance in treatment for patients with relapsed/refractory B-cell malignancies. Although a significant minority of recipients are women during their reproductive years, there is a paucity of data regarding pregnancy and neonatal outcomes in women previously treated with CAR-T. This is important as maternal T cells are known to cross the placenta and into breastmilk during pregnancy and breastfeeding, respectively.</p><p><strong>Case presentation: </strong>Here we present two successful pregnancies following CAR-T therapy where both neonates were initially breastfed. These represent the first cases of neonates born following CAR-T therapy comprehensively described in medical literature.</p><p><strong>Conclusion: </strong>Pregnancy following CAR-T therapy does not appear to be associated with adverse neonatal outcomes. Further work is required to delineate the outcomes in this population.</p>","PeriodicalId":94152,"journal":{"name":"Neonatology","volume":" ","pages":"1-5"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Neonatal Outcomes following 2 Cases of Maternal CAR-T Therapy for High-Grade B-Cell Lymphoma.\",\"authors\":\"Daniel O'Reilly, Charlotte Jones, Aisling Smith, David Mackin, Laura Mc Donald, John Quinn, Maeve O'Reilly, Aisling M Flinn, Ronan Leahy, David Williams, Jennifer Donnelly, David Corcoran\",\"doi\":\"10.1159/000542016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Introduction: </strong>Chimeric antigen receptor T cells (CAR-Ts) targeting CD19 represent a significant advance in treatment for patients with relapsed/refractory B-cell malignancies. Although a significant minority of recipients are women during their reproductive years, there is a paucity of data regarding pregnancy and neonatal outcomes in women previously treated with CAR-T. This is important as maternal T cells are known to cross the placenta and into breastmilk during pregnancy and breastfeeding, respectively.</p><p><strong>Case presentation: </strong>Here we present two successful pregnancies following CAR-T therapy where both neonates were initially breastfed. These represent the first cases of neonates born following CAR-T therapy comprehensively described in medical literature.</p><p><strong>Conclusion: </strong>Pregnancy following CAR-T therapy does not appear to be associated with adverse neonatal outcomes. Further work is required to delineate the outcomes in this population.</p>\",\"PeriodicalId\":94152,\"journal\":{\"name\":\"Neonatology\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Neonatology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1159/000542016\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neonatology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1159/000542016","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
简介以 CD19 为靶点的嵌合抗原受体 T 细胞（CAR-T）是治疗复发/难治性 B 细胞恶性肿瘤患者的一大进步。虽然有相当一部分接受者是育龄期妇女，但有关曾接受过 CAR-T 治疗的妇女的妊娠和新生儿预后的数据却很少。这一点非常重要，因为众所周知，母体 T 细胞会在妊娠和哺乳期间分别穿过胎盘和进入母乳：在此，我们介绍了两例在接受 CAR-T 治疗后成功怀孕的病例，这两例病例的新生儿最初都是母乳喂养。这些病例是医学文献中全面描述的第一例接受 CAR-T 疗法后出生的新生儿：结论：CAR-T疗法后妊娠似乎与新生儿不良结局无关。结论：CAR-T疗法后妊娠似乎与新生儿的不良预后无关。
Neonatal Outcomes following 2 Cases of Maternal CAR-T Therapy for High-Grade B-Cell Lymphoma.
Introduction: Chimeric antigen receptor T cells (CAR-Ts) targeting CD19 represent a significant advance in treatment for patients with relapsed/refractory B-cell malignancies. Although a significant minority of recipients are women during their reproductive years, there is a paucity of data regarding pregnancy and neonatal outcomes in women previously treated with CAR-T. This is important as maternal T cells are known to cross the placenta and into breastmilk during pregnancy and breastfeeding, respectively.
Case presentation: Here we present two successful pregnancies following CAR-T therapy where both neonates were initially breastfed. These represent the first cases of neonates born following CAR-T therapy comprehensively described in medical literature.
Conclusion: Pregnancy following CAR-T therapy does not appear to be associated with adverse neonatal outcomes. Further work is required to delineate the outcomes in this population.
京公网安备 11010802042870号
京ICP备2023020795号-1
分享
求助内容：
应助结果提醒方式：
扫码关注我们
