{"title":"苯胺与乙烯基氮丙啶在六氟异丙醇中的正烯丙基化反应","authors":"Jing-Jing Nie , Zhong-Xia Wang","doi":"10.1039/d4qo01719f","DOIUrl":null,"url":null,"abstract":"<div><div>Transition-metal-free reaction of <em>N</em>,<em>N</em>-dialkylanilines with 1-sulfonyl-2-vinylaziridines in hexafluoroisopropanol under air gave <em>ortho</em>-allylated anilines in moderate to excellent yields. The reaction also features mild reaction conditions, <em>ortho</em>-monoallylation selectivity, <em>E</em>-configured C–C double bonds, wide substrate scope and good compatibility of functional groups.</div></div>","PeriodicalId":94379,"journal":{"name":"Organic chemistry frontiers : an international journal of organic chemistry","volume":"12 2","pages":"Pages 629-635"},"PeriodicalIF":0.0000,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"ortho-Allylation of anilines with vinylaziridines in hexafluoroisopropanol†\",\"authors\":\"Jing-Jing Nie , Zhong-Xia Wang\",\"doi\":\"10.1039/d4qo01719f\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>Transition-metal-free reaction of <em>N</em>,<em>N</em>-dialkylanilines with 1-sulfonyl-2-vinylaziridines in hexafluoroisopropanol under air gave <em>ortho</em>-allylated anilines in moderate to excellent yields. The reaction also features mild reaction conditions, <em>ortho</em>-monoallylation selectivity, <em>E</em>-configured C–C double bonds, wide substrate scope and good compatibility of functional groups.</div></div>\",\"PeriodicalId\":94379,\"journal\":{\"name\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"volume\":\"12 2\",\"pages\":\"Pages 629-635\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2024-11-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Organic chemistry frontiers : an international journal of organic chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.sciencedirect.com/org/science/article/pii/S2052412924008088\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2024/11/14 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic chemistry frontiers : an international journal of organic chemistry","FirstCategoryId":"1085","ListUrlMain":"https://www.sciencedirect.com/org/science/article/pii/S2052412924008088","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2024/11/14 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
摘要
在六氟异丙醇中，N,N-二烷基苯胺与 1-磺酰基-2-乙烯基氮丙啶在空气中进行无过渡金属反应，可获得中等至极好收率的正烯丙基苯胺。该反应还具有反应条件温和、正单烯丙基化选择性高、C-C 双键为 E 构型、底物范围广以及官能团兼容性好等特点。
ortho-Allylation of anilines with vinylaziridines in hexafluoroisopropanol†
Transition-metal-free reaction of N,N-dialkylanilines with 1-sulfonyl-2-vinylaziridines in hexafluoroisopropanol under air gave ortho-allylated anilines in moderate to excellent yields. The reaction also features mild reaction conditions, ortho-monoallylation selectivity, E-configured C–C double bonds, wide substrate scope and good compatibility of functional groups.
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