海洋天然产品通过 Nrf2/HO-1 细胞保护途径的氧化还原调节作用发挥抗糖尿病作用

IF 4.6 Q2 MATERIALS SCIENCE, BIOMATERIALS ACS Applied Bio Materials Pub Date : 2024-11-13 DOI:10.3389/fmars.2024.1438955
Muhammad Farrukh Nisar, Mingxi Li, Jialin Xu, Chunpeng Wan
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引用次数: 0

摘要

糖尿病(DM)是一种慢性代谢紊乱疾病,是全球关注的主要健康问题。最近,从众多海洋天然产品中提取的生物活性化合物作为新型治疗方法引起了人们的关注。考虑到这些化学物质及其在细胞氧化还原调节中的作用,并通过涉及核因子红细胞 2 相关因子 2(Nrf2)/血红素加氧酶 1(HO-1)途径,目前的研究试图强调它们的抗糖尿病作用及其所涉及的分子机制。活性氧(ROS)介导的氧化应激、炎症和细胞损伤与大多数人类病症(尤其是糖尿病)有关。Nrf2/HO-1途径是细胞为对抗ROS爆发而开发的一种关键防御机制。海洋天然化合物具有很强的药理潜力,可通过减少与 DM 有关的氧化损伤和炎症来触发细胞抗氧化防御机制。海洋天然产品如何潜在地缓解 DM,特别是 2 型糖尿病(T2D)及其相关问题是研究的重点。我们对文献进行了深入分析,就特定海洋化合物及其公认的抗糖尿病作用展开讨论,以阐明可能的治疗应用。此外,还讨论了使用这些海洋生物活性化合物作为糖尿病辅助治疗的机会和利弊。海洋天然产品的各种特性,特别是在氧化还原控制方面的特性,为药物发现和临床试验中的治疗干预提供了大有可为的机会。
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Anti-diabetic effects of marine natural products through redox modulation via Nrf2/HO-1 cytoprotective pathways
Diabetes mellitus (DM), a major global health concern, is a chronic metabolic disorder. Bioactive compounds sourced from numerous marine natural products recently have drawn attention as novel therapeutic approaches. Considering these chemicals and their role in cellular redox modulation by involving the nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase 1 (HO-1) pathway, the current study attempts to highlight their anti-diabetic effects and the molecular mechanisms involved. Reactive oxygen species (ROS)-mediated oxidative stress, inflammation, and cellular damage are linked to most human pathologies specifically DM. The Nrf2/HO-1 pathway is a key defense mechanism developed by the cells to combat ROS burst. Marine natural compounds have strong pharmacological potential in triggering cellular antioxidant defense mechanisms by declining oxidative damage and inflammation linked to DM. How marine natural products potentially alleviate DM specifically type 2 diabetes (T2D) and its related issues is especially focused on. The literature was thoroughly analyzed to open a discussion about specific marine compounds and their well-established anti-diabetic effects to elucidate possible therapeutic applications. Furthermore, opportunities and the pros and cons of using these marine bioactive compounds as complementary treatment for DM are also discussed. The diverse characteristics of marine natural products, specifically with regard to redox control, offer promising opportunities for drug discovery and therapeutic interventions in clinical trials.
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来源期刊
ACS Applied Bio Materials
ACS Applied Bio Materials Chemistry-Chemistry (all)
CiteScore
9.40
自引率
2.10%
发文量
464
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