Ting Wu , Xining Zhang , Shuangfei Cai , Wei Zhang , Rong Yang
{"title":"普鲁士蓝纳米笼作为高效自由基清除剂和光热剂，可降低淀粉样蛋白-β诱导的神经毒性。","authors":"Ting Wu , Xining Zhang , Shuangfei Cai , Wei Zhang , Rong Yang","doi":"10.1016/j.colsurfb.2024.114369","DOIUrl":null,"url":null,"abstract":"<div><div>The unusual accumulation of amyloid-beta 1–42 (A<em>β</em><sub>42</sub>) is an essential pathological feature of Alzheimer’s disease (AD), and development of A<em>β</em><sub>42</sub> nanomodulators offers a potentially therapeutic approach to AD. Here, we report facile synthesis of the hollow mesocrystalline Prussian blue nanocages (HMPBs), which serve as versatile A<em>β</em><sub>42</sub> modulators. Due to the hollow nanostructures and large specific surface area, they can effectively inhibit A<em>β</em><sub>42</sub> aggregation by adsorption. They also exhibit robust near-infrared (NIR) photothermal effect for light-to-heat transition, which promotes the depolymerization of A<em>β</em><sub>42</sub> fibers. Besides, they display ROS quenching ability to scavenge hydroxyl radicals (•OH) caused by A<em>β</em><sub>42</sub> fibers, alleviate cellular oxidative stress, and improve cell survival. This work provides a new kind of Prussian blue nanomaterial for multimodal A<em>β</em> modulation.</div></div>","PeriodicalId":279,"journal":{"name":"Colloids and Surfaces B: Biointerfaces","volume":"246 ","pages":"Article 114369"},"PeriodicalIF":5.4000,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Prussian blue nanocages as efficient radical scavengers and photothermal agents for reducing amyloid-beta induced neurotoxicity\",\"authors\":\"Ting Wu , Xining Zhang , Shuangfei Cai , Wei Zhang , Rong Yang\",\"doi\":\"10.1016/j.colsurfb.2024.114369\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>The unusual accumulation of amyloid-beta 1–42 (A<em>β</em><sub>42</sub>) is an essential pathological feature of Alzheimer’s disease (AD), and development of A<em>β</em><sub>42</sub> nanomodulators offers a potentially therapeutic approach to AD. Here, we report facile synthesis of the hollow mesocrystalline Prussian blue nanocages (HMPBs), which serve as versatile A<em>β</em><sub>42</sub> modulators. Due to the hollow nanostructures and large specific surface area, they can effectively inhibit A<em>β</em><sub>42</sub> aggregation by adsorption. They also exhibit robust near-infrared (NIR) photothermal effect for light-to-heat transition, which promotes the depolymerization of A<em>β</em><sub>42</sub> fibers. Besides, they display ROS quenching ability to scavenge hydroxyl radicals (•OH) caused by A<em>β</em><sub>42</sub> fibers, alleviate cellular oxidative stress, and improve cell survival. This work provides a new kind of Prussian blue nanomaterial for multimodal A<em>β</em> modulation.</div></div>\",\"PeriodicalId\":279,\"journal\":{\"name\":\"Colloids and Surfaces B: Biointerfaces\",\"volume\":\"246 \",\"pages\":\"Article 114369\"},\"PeriodicalIF\":5.4000,\"publicationDate\":\"2024-11-07\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Colloids and Surfaces B: Biointerfaces\",\"FirstCategoryId\":\"1\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0927776524006283\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"BIOPHYSICS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Colloids and Surfaces B: Biointerfaces","FirstCategoryId":"1","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0927776524006283","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"BIOPHYSICS","Score":null,"Total":0}
Prussian blue nanocages as efficient radical scavengers and photothermal agents for reducing amyloid-beta induced neurotoxicity
The unusual accumulation of amyloid-beta 1–42 (Aβ42) is an essential pathological feature of Alzheimer’s disease (AD), and development of Aβ42 nanomodulators offers a potentially therapeutic approach to AD. Here, we report facile synthesis of the hollow mesocrystalline Prussian blue nanocages (HMPBs), which serve as versatile Aβ42 modulators. Due to the hollow nanostructures and large specific surface area, they can effectively inhibit Aβ42 aggregation by adsorption. They also exhibit robust near-infrared (NIR) photothermal effect for light-to-heat transition, which promotes the depolymerization of Aβ42 fibers. Besides, they display ROS quenching ability to scavenge hydroxyl radicals (•OH) caused by Aβ42 fibers, alleviate cellular oxidative stress, and improve cell survival. This work provides a new kind of Prussian blue nanomaterial for multimodal Aβ modulation.
期刊介绍：
Colloids and Surfaces B: Biointerfaces is an international journal devoted to fundamental and applied research on colloid and interfacial phenomena in relation to systems of biological origin, having particular relevance to the medical, pharmaceutical, biotechnological, food and cosmetic fields.
Submissions that: (1) deal solely with biological phenomena and do not describe the physico-chemical or colloid-chemical background and/or mechanism of the phenomena, and (2) deal solely with colloid/interfacial phenomena and do not have appropriate biological content or relevance, are outside the scope of the journal and will not be considered for publication.
The journal publishes regular research papers, reviews, short communications and invited perspective articles, called BioInterface Perspectives. The BioInterface Perspective provide researchers the opportunity to review their own work, as well as provide insight into the work of others that inspired and influenced the author. Regular articles should have a maximum total length of 6,000 words. In addition, a (combined) maximum of 8 normal-sized figures and/or tables is allowed (so for instance 3 tables and 5 figures). For multiple-panel figures each set of two panels equates to one figure. Short communications should not exceed half of the above. It is required to give on the article cover page a short statistical summary of the article listing the total number of words and tables/figures.
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