DNA 调控元件在转录中的合作与竞争。

IF 2.9 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY BMB Reports Pub Date : 2024-11-11

Haram Lee, Meyer Joseph Friedman, Sang Bum Kim, Soohwan Oh

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引用次数: 0

摘要

真核生物转录调控是一个复杂的过程，可实现对基因表达的精确时空控制。启动子是位于转录起始位点（TSS）近端的顺式调控元件（CRE），可选择性地整合来自远端 CRE 或增强子及其相关转录机制的调控线索。在这篇综述中，我们讨论了目前有关影响基因表达的 CRE 合作与竞争的知识，包括增强子-启动子、增强子-增强子和启动子-启动子相互作用的特征。我们还概述了最近对促进调控元件物理和功能相互作用的潜在分子机制的见解，如增强子 RNA 和生物分子凝聚体的参与。

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DNA regulatory element cooperation and competition in transcription.

Regulation of eukaryotic transcription is a complex process that enables precise temporal and spatial control of gene expression. Promoters, which are cis-regulatory elements (CREs) located proximal to the transcription start site (TSS), selectively integrate regulatory cues from distal CREs, or enhancers, and their associated transcriptional machinery. In this review, we discuss current knowledge regarding CRE cooperation and competition impacting gene expression, including features of enhancer-promoter, enhancer-enhancer, and promoter-promoter interplay. We also provide an overview of recent insights into the underlying molecular mechanisms that facilitate physical and functional interaction of regulatory elements, such as the involvement of enhancer RNAs and biomolecular condensates.

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来源期刊

BMB Reports 生物-生化与分子生物学

CiteScore

5.10

自引率

7.90%

发文量

141

审稿时长

1 months

期刊介绍： The BMB Reports (BMB Rep, established in 1968) is published at the end of every month by Korean Society for Biochemistry and Molecular Biology. Copyright is reserved by the Society. The journal publishes short articles and mini reviews. We expect that the BMB Reports will deliver the new scientific findings and knowledge to our readers in fast and timely manner.